DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgk and DGK1

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	NP_001331085.1	Gene:	DGK1 / 830686	AraportID:	AT5G07920	Length:	728	Species:	Arabidopsis thaliana

Alignment Length:	948	Identity:	175/948 - (18%)
Similarity:	264/948 - (27%)	Gaps:	476/948 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 HVWRLKHFSKPAYCNLCLNMLVGLGKKGLC--------CVLCKYTVHERCVQHAPASCITTYVKS 466
            |.|.|...::....|.|:.:......:.:.        |.:|....|..|...||..|
plant    80 HSWELDPIARAKNLNCCVCLKSMSPSQAIVASESFFHRCTICGAAAHFNCSSSAPKDC------- 137

  Fly   467 KKPKC----GGDLLHH-----WVEG----NCYGRCSKCRKRIKA--YHGITGLTCRWCHMMLHNR 516
               ||    |.:.:.|     |.||    :....||.|.:...:  ..|.....|.||..::|..
plant   138 ---KCVSMVGFEHVVHQWAVRWTEGADQTDDSSFCSYCDESCSSSFLGGSPIWCCLWCQRLVHVD 199

  Fly   517 CASSVKKE----CTLGEYSELIVPP---------------------------TAIC--------- 541
            |.|::..|    |.||....||:.|                           ||:.
plant   200 CHSNMSNETGDICDLGPLRRLILCPLYVKELTRNPSGGFLSSITHGANELASTALASIRIQSKKY 264

  Fly   542 ---------------------PAVLDRQRSVNQAHKATHFQIT---------------------- 563
                                 .:..|...:||.||......|:
plant   265 KQTNETSADTGNSGSNCDESTESTADTGPTVNGAHAVLENSISVMNGDSSNGDSDSNGKLEKKPS 329

  Fly   564 --------------------------PPDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVY 602
                                      |.|  :.|||||:|.|||.::||.:.::....|||.||:
plant   330 VKRTGSFGQKEYHALRSKLKYELADLPSD--ARPLLVFINKKSGAQRGDSLRQRLHLHLNPVQVF 392

  Fly   603 DLSK-GGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCL 666
            :||. .||:.||.||:.:|.|||:.||||||.||||:|::.....|.||:.::|.||||||:|.|
plant   393 ELSSVQGPEVGLFLFRKVPHFRVLVCGGDGTAGWVLDAIEKQNFISPPAVAILPAGTGNDLSRVL 457

  Fly   667 RWGGGY-----EGENIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQ 726
            .||||.     :| .:..::.....|:..:||||.:.:.|
plant   458 NWGGGLGSVERQG-GLSTVLQNIEHAAVTVLDRWKVSILN------------------------- 496

  Fly   727 SVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTT 791

plant   497 ----------------------------------------------------------------- 496

  Fly   792 TKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSG 856

plant   497 ----------------------------------------------------------------- 496

  Fly   857 ETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQI 921

plant   497 ----------------------------------------------------------------- 496

  Fly   922 TLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQ 986
                                                                 ||.:.||
plant   497 -----------------------------------------------------QQGKQLQ----- 503

  Fly   987 KPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFA 1051
                         |...:|||..||.||.:.::.|..||:||.:|.|:..||:.|..........
plant   504 -------------PPKYMNNYIGVGCDAKVALEIHNLREENPERFYSQFMNKVLYAREGARSIMD 555

  Fly  1052 ASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSK 1116
            .:.::....:.:..|||.:::..  ..:|:.:.||....||.:||...
plant   556 RTFEDFPWQVRVEVDGVDIEVPE--DAEGILVANIGSYMGGVDLWQNE----------------- 601

  Fly  1117 KLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIK 1181
                 |:.:.  :|:.       |...|:::||:.:....|:|:::.|| :..|||||.|.|.|:
plant   602 -----DETYE--NFDP-------QSMHDKIVEVVSISGTWHLGKLQVGL-SRARRLAQGSAVKIQ 651

  Fly  1182 TKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSE 1219
            .....|:|||||||.|.|||:.::|..|..||.....|
plant   652 LCAPLPVQIDGEPWNQQPCTLTISHHGQAFMLKRAAEE 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199
		EFh	317..386	CDD:238008
		EF-hand_7	318..382	CDD:290234
		C1	410..459	CDD:237996	11/56 (20%)
		C1_1	477..528	CDD:278556	16/65 (25%)
		DAGKc	573..694	CDD:214487	56/126 (44%)
		DAGKa	1003..1194	CDD:214486	50/190 (26%)
DGK1	NP_001331085.1	C1	80..137	CDD:197519	11/56 (20%)
		C1_DGK_rpt2	150..215	CDD:410355	16/64 (25%)
		DAGKc	363..489	CDD:214487	56/126 (44%)
		DAGK_acc	508..664	CDD:395484	50/189 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	120	1.000	Domainoid score	I1884
eggNOG	1	0.900	-	-		E1_KOG1169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102301
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X838
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.670