Protein Alignment Dgk and Dgkz

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: NP_001416441.1
• Gene: Dgkz / 81821
• RGDID: 70929
• Length: 1121
• Species: Rattus norvegicus
• Alignment Length: 857
• Identity: 193/857 - (22%)
• Similarity: 285/857 - (33%)
• Gaps: 380/857 - (44%)

  Fly   408 GIHVWRLKHFSKPAYC----NLCLNMLVGLGKKGLCCVLCKYTVHERCV---QHAPASCITTYVK 465
            |.|:|...:.|.. :|    ..|:..::........|..||..||..|:   :.....|..::.:
  Rat   288 GEHIWFETNVSGD-FCYVGEQYCVAKMLPKSAPRRKCAACKIVVHTPCIGQLEKINFRCKPSFRE 351

  Fly   466 S-----KKPKCGGDLLHHWVEGNCY-GRCSKCRKRIK---AYHG--ITGLTCRWCHMMLHNRCA- 518
            |     ::|..   :.||||..... |:|..|.|..:   .:|.  |..::|.||....|::.:
  Rat   352 SGSRNVREPTF---VRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSC 413

  Fly   519 ---SSVKKECTLGEYSELIVPPTAICPAVLDRQRSVNQAHKATH--------------------F 560
               ..:::.|:||.::.:::|||.|..|  .|.::..:|.|...                    |
  Rat   414 FMLQQIEEPCSLGVHAAVVIPPTWILRA--RRPQNTLKASKKKKRASFKRRSSKKGPEEGRWRPF 476

  Fly   561 QITP-PDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRV 624
            .|.| |..|..||||||||||||.||.:|::.|.:.||||||:|||:|||:|.|.:::.:...|:
  Rat   477 IIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPREALEMYRKVHNLRI 541

  Fly   625 ICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRAST 689
            :.|||||||||:|..:|.:.|...|.:.::||||||||||.|.|||||..|.:.|::......:.
  Rat   542 LACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNV 606

  Fly   690 VMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGT 754
            |.||||.:.....|.
  Rat   607 VQLDRWDLRAEPNPE-------------------------------------------------- 621

  Fly   755 AASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSN 819
                                                                             
  Rat   622 ----------------------------------------------------------------- 621

  Fly   820 TSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQG 884
                                                                             
  Rat   622 ----------------------------------------------------------------- 621

  Fly   885 VTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNG 949
                       |.|                                  |.:|||.
  Rat   622 -----------AGP----------------------------------EERDDGA---------- 631

  Fly   950 NSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDA 1014
                                                       :|:   :|.::.|||||:|.||
  Rat   632 -------------------------------------------TDR---LPLDVFNNYFSLGFDA 650

  Fly  1015 AICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQ 1079
            .:.::||..||.||.|||||.:||::|...|.|:....|.|:|.:.|.:||||  :||.  |.:|
  Rat   651 HVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDG--MDLT--PKIQ 711

  Fly  1080 G-----VALLNIPYTHGGSNLW---GEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLS 1136
            .     :..||||....|:..|   |||                       .:|..
  Rat   712 DLKPQCIVFLNIPRYCAGTMPWGHPGEH-----------------------HDFEP--------- 744

  Fly  1137 VAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCT 1201
               |...|..:||||. ....:..::.|  ..|.||.||.||::.|.|..|:|:||||.......
  Rat   745 ---QRHDDGYLEVIGF-TMTSLAALQVG--GHGERLTQCREVLLTTAKAIPVQVDGEPCKLAASR 803

  Fly  1202 IKVTHKNQVPML 1213
            |::..:||..|:
  Rat   804 IRIALRNQATMV 815

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008
		C1_DGKbeta_rpt1	403..468	CDD:410395	14/71 (20%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	15/60 (25%)
		DAGKc	573..694	CDD:214487	62/120 (52%)
		DAGKa	1003..1194	CDD:214486	66/198 (33%)
Dgkz	NP_001416441.1	None