DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgk and DGK3

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	NP_849980.1	Gene:	DGK3 / 816388	AraportID:	AT2G18730	Length:	488	Species:	Arabidopsis thaliana

Alignment Length:	742	Identity:	134/742 - (18%)
Similarity:	201/742 - (27%)	Gaps:	356/742 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   497 AYHGITGLTCRWCHMM---LHNRCASSVKKECTLGEYSELIVPPTAICPAVLDRQRSVNQAHKAT 558
            |:.|:..:..|...||   |.......:|::.:......|::|..|:             |..|.
plant    37 AWVGVDKVELRQRLMMPEYLRLAMRDCIKRKDSSAIPDHLLLPGGAV-------------ADMAP 88

  Fly   559 HFQITPPDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKE----GLTLFKDL 619
            |          .|::||:||.||||.|..:..:.|.:::..||:||::..|.|    ||...:.:
plant    89 H----------APMVVFINPNSGGRHGPVLKERLQQLMSEEQVFDLTEVKPHEFVRYGLGCLEKV 143

  Fly   620 ------------PRFRVICCGGDGTVGWVLEAMDSIELASQ---PAIGVIPLGTGNDLARCLRWG 669
                        .|.|::..||||||||||..:..:....:   |.:|||||||||||:|...||
plant   144 AAEGDECAKECRARLRIMVAGGDGTVGWVLGCLGELNKDGKSQIPPVGVIPLGTGNDLSRSFGWG 208

  Fly   670 GGYEGENIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSL 734
            |.:.                   ..|...|..|.|...|.|...|.|  .|::
plant   209 GSFP-------------------FAWRSAVKRTLHRASMGPVARLDS--WKIL------------ 240

  Fly   735 MERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMST 799
                                                                        :||.
plant   241 ------------------------------------------------------------VSMP- 244

  Fly   800 FETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLE 864
                                                                   |||
plant   245 -------------------------------------------------------SGE------- 247

  Fly   865 TLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSD 929
                                    .|:...:..|...|:.|             |.:...:|
plant   248 ------------------------VVDPPYSLKPAEENELD-------------QGLDAGID--- 272

  Fly   930 HEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSD 994
                                       |.|:...                  :|
plant   273 ---------------------------APPLAKA------------------YE----------- 281

  Fly   995 KDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSE-TFAASCKNLH 1058
                   .:..||.|:|:||.:...||..|...|:.....:.||:.|..:..|: .|...|
plant   282 -------GVFYNYLSIGMDAQVAYGFHHLRNTKPYLAQGPISNKIIYSSFGCSQGWFCTPC---- 335

  Fly  1059 ESIEIVCDGVALDLANGPHLQGVALLNIPYTH---GGSNLWGEHLSQKRIR-----------KSA 1109
                          .|.|.|:|  |.||...|   ...:.|.|....|.:|           ..:
plant   336 --------------VNDPGLRG--LRNIMKIHIKKVNCSQWEEIAVPKNVRSIVALNLHSYGSGS 384

  Fly  1110 GPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQ 1174
            .|:|..|......:.|.....:            |.|||:.|.:...|...|...| .|.:.:||
plant   385 HPWGNLKPDYLEKRGFVEAHCD------------DGLIEIFGFKQGWHASFVMAEL-ISAKHIAQ 436

  Fly  1175 CSEVIIKTK----KTFPMQIDGEPWMQ 1197
            .:.|..:.:    :...:|:|||||.|
plant   437 AAAVRFELRGGDWRDAFLQMDGEPWKQ 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199
		EFh	317..386	CDD:238008
		EF-hand_7	318..382	CDD:290234
		C1	410..459	CDD:237996
		C1_1	477..528	CDD:278556	7/33 (21%)
		DAGKc	573..694	CDD:214487	46/139 (33%)
		DAGKa	1003..1194	CDD:214486	47/209 (22%)
DGK3	NP_849980.1	DAGK_cat	91..231	CDD:279163	52/158 (33%)
DGK3	NP_849980.1	DAGK_acc	283..460	CDD:279003	47/209 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D633642at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780