Protein Alignment Dgk and dgkaa

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: XP_005162385.1
• Gene: dgkaa / 724010
• ZFINID: ZDB-GENE-060616-305
• Length: 766
• Species: Danio rerio
• Alignment Length: 1231
• Identity: 397/1231 - (32%)
• Similarity: 522/1231 - (42%)
• Gaps: 493/1231 - (40%)

  Fly    12 KLSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDGD-IDFDGFRRFLDAFLDCE-AP 74
            :|.|.:|:|||:...|.:.|::|||:||::....:..:   .|: ||.:|||.||..:|:.| .|
Zfish    11 ELRPVDFIQLQQYIDYCSLKVKDVLKEFNADGRLAKYR---HGECIDEEGFRLFLKTYLEVEDFP 72

  Fly    75 LDLAKHLFVSFLKPNVTQAQLHGRALNQMAAISSTAACAPVTSHTKGSIPNINSIAELMPQCSGG 139
            .||.:.||.||
Zfish    73 SDLCQRLFRSF------------------------------------------------------ 83

  Fly   140 GGGIGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPSKTGSVHPMLTVTPSPLAS 204
                      ..:|......:|:::                   |..:..|:...|..|......
Zfish    84 ----------QNSESAKSDENSWIE-------------------DEDEDCSILYTLETTDKETTM 119

  Fly   205 GPSMFQASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDAVSRILPAIGRHCPGSLES 269
            |                       |..|....:.:||.
Zfish   120 G-----------------------NRKQKQGVARRKSG--------------------------- 134

  Fly   270 GSAQAEKRADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLEFMFRLYDTDSNGVLD 334
                                      :|.||||.||.||||.|:|.|||:|.|:|||.|.||.||
Zfish   135 --------------------------EVFLKDVSCYFSLLEEGQPRDKLDFAFKLYDRDGNGFLD 173

  Fly   335 TAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMTTIPLLVLLGV 399
            ::|:|.|:.|||..|:|||||||||||:|::||..||.|:.||||.:||..||:..:|||||||:
Zfish   174 SSEVDRIIAQMMHAADYLGWDVSELRPVLKDMMTAIDADSSGTVSSEEWVDGGLKNVPLLVLLGL 238

  Fly   400 DSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITTYV 464
            ..|  ::||.|:||:|||:||.|||:|.|||:||.|:||||..|:||||.||....||.|..|||
Zfish   239 KMT--QKDGQHLWRMKHFNKPVYCNVCQNMLLGLRKQGLCCTCCRYTVHGRCANKNPAPCTRTYV 301

  Fly   465 KSKKPKCGGDLLHHWVEGNC-YGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSVKKECTLG 528
            .|||..  |..:|.||.||| .|:|..|:|:||:.||:||..|.|||.|.|:.||:.....|..|
Zfish   302 MSKKET--GIAVHDWVSGNCDSGKCDGCQKKIKSLHGLTGKRCVWCHTMRHDACATQEPFTCDCG 364

  Fly   529 EYSELIVPPTAICPAVLDRQRSV-------------NQAHKATHFQITP-PDELSCPLLVFVNPK 579
            .:...|:||.||.|.|.:|...:             |........:|:| ||  :.|||||||||
Zfish   365 PFKVHILPPWAIYPVVKERPNCIKNGGSFPDDDSELNTTPDGQVLRISPIPD--TRPLLVFVNPK 427

  Fly   580 SGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIE 644
            |||:||:|:||||||:|||||||:||.|||..||:.|:|:|.:|::.|||||||||:|:|:|...
Zfish   428 SGGKQGERVLRKFQYLLNPRQVYNLSNGGPGPGLSFFRDVPNYRILVCGGDGTVGWILDAIDKAN 492

  Fly   645 LASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMR 709
            |..:|.:.|:||||||||||||||||||:|.::.:::.....:....:|||||:||
Zfish   493 LPVRPPVAVLPLGTGNDLARCLRWGGGYDGMDLGRILKDIEVSEEGPMDRWSIQVT--------- 548

  Fly   710 PKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETM 774
                        :|.||         ||
Zfish   549 ------------LEDSQ---------ER------------------------------------- 555

  Fly   775 ATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSH 839
                                                            |.|
Zfish   556 ------------------------------------------------GDP-------------- 558

  Fly   840 AAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQS 904
                                                                             
Zfish   559 ----------------------------------------------------------------- 558

  Fly   905 DNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAAS 969
                                                                             
Zfish   559 ----------------------------------------------------------------- 558

  Fly   970 SVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSR 1034
                                         |||.|||||||:||||:|..:||..|||:|.|||||
Zfish   559 -----------------------------VPYEIINNYFSIGVDASIAHRFHTMREKHPQKFNSR 594

  Fly  1035 MKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEH 1099
            |||||||||:|||||.:||||.|.|.:.|.|.|..|||:: ..|:|:|:||||..|||||||||
Zfish   595 MKNKLWYFEFATSETISASCKKLKECLTIECCGTQLDLSS-LSLEGIAILNIPSMHGGSNLWGE- 657

  Fly  1100 LSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTG 1164
                           :||....|::......:...|.|:.||..|:.:||:|||..:.|||:.||
Zfish   658 ---------------AKKSDRMDQKLPEVIVDPEILKVSPQDMSDKRLEVVGLEGAMEMGQIYTG 707

  Fly  1165 LRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSEKGRGFF 1225
            |: |..|||:.|::.|:|||..|||||||||||.||||.:|||||..|||.|:::.  |||
Zfish   708 LK-SAVRLAKTSQITIRTKKPLPMQIDGEPWMQPPCTIHITHKNQASMLMGPQAKS--GFF 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196	30/106 (28%)
		EFh	317..386	CDD:238008	42/68 (62%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	38/64 (59%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	25/51 (49%)
		DAGKc	573..694	CDD:214487	71/120 (59%)
		DAGKa	1003..1194	CDD:214486	99/190 (52%)
dgkaa	XP_005162385.1	DAG_kinase_N	11..152	CDD:464196	52/302 (17%)
		EFh	156..225	CDD:238008	42/68 (62%)
		C1_DGK_typeI_rpt1	242..303	CDD:410349	37/60 (62%)
		C1_DGKalpha_rpt2	312..373	CDD:410440	27/60 (45%)
		DAGKc	421..542	CDD:214487	71/120 (59%)
		DAGK_acc	563..736	CDD:459866	99/190 (52%)