Protein Alignment Dgk and CG34384

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: NP_001246971.1
• Gene: CG34384 / 5740362
• FlyBaseID: FBgn0085413
• Length: 1936
• Species: Drosophila melanogaster
• Alignment Length: 1734
• Identity: 327/1734 - (18%)
• Similarity: 504/1734 - (29%)
• Gaps: 825/1734 - (47%)

  Fly   228 TNHSQM----SRNSSKKSSNSVNCKIDAVS--RILPAIGRHCPGSLESGSAQAEKRADI-----K 281
            |.|.|.    ||.||..|..|..|...::|  .|:|.|      |:.....::|..::|     :
  Fly     8 TLHVQRSPRGSRRSSPSSGRSSACSSGSISPVPIIPII------SISHDGDESESESEIETEPAR 66

  Fly   282 LLARKLSHFDPLTLKVPLKDVVC-------------YLSLLEAGRPEDKLEFMFRLYDTDSNGVL 333
            |..|::|......|...:|:...             |..|        |...:|...| :...|.
  Fly    67 LFQRRMSTKCTNNLAAIIKEGFLLKHTWSFQRWRRRYFRL--------KRNMLFYAKD-EKCDVF 122

  Fly   334 DTAEMDAI---------VNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMT 389
            |..::..:         ||....:       ::..|.::        ..|:....:::| .|.:.
  Fly   123 DDIDLSDLCYFECGIKNVNHSFQI-------ITPTRSLV--------LCAESRREMEDW-LGSLK 171

  Fly   390 TIPLLVLLGVDSTTLKEDGI----HVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHER 450
            |.........||..:::..|    |.|.....::|.|||:|.:.|.|:...||.|.:||..||:|
  Fly   172 TATAPQRPRGDSFLIEQHDILSNHHHWYATSHARPTYCNVCRDALSGVTSHGLSCEVCKCKVHKR 236

  Fly   451 CVQHAPASCITTYVKSKKPKCGGDLL---------HHWVEGN--CYGRCSKCRKRIKAYHGITGL 504
            |...:.|:|..|.:.|    .|.|::         |.|:|||  ....|:.|:|...:...:...
  Fly   237 CAAKSIANCKWTTLAS----VGKDIIEQADGIIMPHQWMEGNLPVSSMCAVCKKTCGSVLRLQDW 297

  Fly   505 TCRWCHMMLHNRCASSVKKECTLGEYSELIVPPTAICPAVLDRQRSVNQAHKATHFQITPPDELS 569
            .|.||...:|..|...:...|.:|.....:||||           ||:.......:.:..|....
  Fly   298 RCLWCRATVHVACRPQMAVACPIGPAKLSVVPPT-----------SVHSISTDDAWDVASPKGNF 351

  Fly   570 CPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVG 634
            .|||||||.|||..||.:.||:|:.:|||.||:||...||..||.||:....||::.|.|||:||
  Fly   352 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLISTGPSLGLRLFRHFEMFRILVCSGDGSVG 416

  Fly   635 WVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGE-NIPKLMDKFRRASTVMLDRWSIE 698
            |||..:|...:..|..:.|:||||||||||.|.||...:.: ::|::::::..|||.|||||||.
  Fly   417 WVLSEIDRFNMHKQCQVAVMPLGTGNDLARVLGWGSSCDDDTHLPQILERYESASTKMLDRWSIM 481

  Fly   699 VTNTPHSDDMRPKVTL---------------HSNMQKVIELSQSVVVDKS----------LMERF 738
            |..........||:::               :.:::.::|.:.:..:.:|          |:.|.
  Fly   482 VFEKAIPVPKTPKMSISTEQEAMLTGMVTSANHHLRFIVETNDTQTLIRSTRNLCDTVDDLVCRI 546

  Fly   739 EEIQRQSKQ--------------------------------VATSMGTAASSTSIMMASKT---- 767
            .|..:..:|                                :||.....|.|..:...|..
  Fly   547 SEHHKDDEQLAVKCDILRQKLNMLLDALQEEEIGAHSGDDLIATIRSLIARSIPVTPGSNAYLLN 611

  Fly   768 ------ETEMETMATMEFGSSTTTTN--------RTTTTK--------------------SISMS 798
                  :||.:.:.|.|..:|.:..:        |..:.|                    .:|::
  Fly   612 PNISIEKTEKDQINTKERRNSRSLRSSEKEALQCRANSVKRAIYNVVEHSEPGRPKRYQRKLSIT 676

  Fly   799 TFE-----------TQC---------------------------LQQTLRTAMSS---------- 815
            .||           |.|                           |..|.|.::..
  Fly   677 PFEALKLPTASGESTPCTSPLPIIPPINIISPTMETSRLTCISPLPDTRRDSVDENFFNSINLPA 741

  Fly   816 ----SSSNTSSG-------------------------------------SPCN------------ 827
                :.|..|||                                     |||:
  Fly   742 PRQFADSRRSSGVEVIQEIEEGANGETVYRKSRMSLTGGANIDDAGNRLSPCSDAGENTPTERKV 806

  Fly   828 ---------------------------------------------------------------GN 829
                                                                           |:
  Fly   807 DFLRVPIHTGEPIVDPLCDYRPHEVFERTYYMTREMDKGKEKDKEKDKPVEIDKEKDTCVEKEGS 871

  Fly   830 QDAE----------------------------TEVDSHA-------------AAAADV------R 847
            ..||                            |.:|:.|             ..|:||      .
  Fly   872 MPAEKLVHTCNLQVPGVVVTPNPQNVYSSASITIIDTDAQTTTEQSSSDDLGGEASDVLSAISNE 936

  Fly   848 EKSV-------------------------------PRRSGETEKQSLETLL------LQHKQQMQ 875
            |.||                               |..|.|||....|:::      |.|.....
  Fly   937 ECSVASEIFDKQDAGQTVGDIIQNMDASNFTHIDSPETSDETEAMPGESIMDDISSVLGHDITYA 1001

  Fly   876 QQQQQQQQGVTSLAVEEAATATPVG---------------------------------------- 900
            .|........|:|..|.|....|..
  Fly  1002 LQDNTLTDDTTTLCSEHAGPPKPPRKKSLSALSRTQAHPRRRNSSPPRMARLARMDSDDNPQQFG 1066

  Fly   901 --------SNQSDNSSQRN-----------KQNNILKQ---QITL--------SLDLSDHEDEPK 935
                    .|:.|:...|.           :.|:|.:|   |:.|        ..|..:||..|.
  Fly  1067 FENIVFEIDNRCDDQKMREPPRYCSLAQFVEGNDIARQSFKQLMLEQHRGGDNDSDYPEHEQTPT 1131

  Fly   936 DDGGG------------------------------------------AGDGTKSNGN-------- 950
            :.|..                                          :...||.:|:
  Fly  1132 NKGANLLATTSEDELSTQTAIKIEIQDIDATVRNLNSSMKPNTILTTSTSPTKKSGHGQDVKRIT 1196

  Fly   951 --------------------SIPATPATP-----ITPT--------------------------- 963
                                |:...|.||     |.||
  Fly  1197 FDESCKKESFDDVNPNYPQISVVVRPPTPLRGDCIKPTVSLLPVSSGGAMTVSMTCSGMLGVRAM 1261

  Fly   964 -------------------------------TPN----------------AAS------SVLQQQ 975
                                           .||                |||      |:.:::
  Fly  1262 NASEIRRHSSHAPGLAVREFDKDKDRRHSGFNPNQLTLDPEHARFLSSSPAASRRISCGSLFKKK 1326

  Fly   976 QQQ-------------------------------------------------------------- 978
            .::
  Fly  1327 NKKIGTKRSYGLFSVRFFVVAEPDFRLATLALIRPLIPLPNEALPNLQTLKGSKSSLFMGSTLFG 1391

  Fly   979 --HLQFEQQQKPIKVQSDKDCT-----------------VP------------------------ 1000
              ||...::.|..|...||:.|                 :|
  Fly  1392 FDHLASAEKDKEEKSGKDKEKTPTDETNRKLPIINPLVRLPNWPNLANGGGFISKCLLANADTLC 1456

  Fly  1001 ----------------YN---IINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYAT 1046
                            |:   ::||||.:|:||.|.:.||.:||::|.|..||.:|.:||....:
  Fly  1457 AAVSPLMDPDETLLAGYHEKCVMNNYFGIGIDAKISLDFHNKREEHPEKCRSRARNYMWYGVLGS 1521

  Fly  1047 SETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGP 1111
            .:....:||||.:.:::.|||..:.|   |.|||:.:||||...||:|.|
  Fly  1522 KQLLQKTCKNLEQRVQLECDGQRIPL---PELQGIVILNIPSFMGGTNFW--------------- 1568

  Fly  1112 FGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCS 1176
             |.|||    |..|...||:            ||::||:.:...:.|...|. :.....|:|||.
  Fly  1569 -GSSKK----DDIFLPPSFD------------DRVLEVVAVFGSVQMAASRL-INLQHHRIAQCQ 1615

  Fly  1177 EVIIKT--KKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRS 1218
            .|.|..  .:..|:|:|||.|:|.|..|::.|||:|.||...||
  Fly  1616 SVQINILGDEEIPIQVDGEAWLQPPGMIRILHKNRVQMLCRNRS 1659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008	10/77 (13%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	23/68 (34%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	14/52 (27%)
		DAGKc	573..694	CDD:214487	59/121 (49%)
		DAGKa	1003..1194	CDD:214486	63/192 (33%)
CG34384	NP_001246971.1	PH_DGK_type2	84..180	CDD:270093	15/120 (13%)
		C1_DGK_typeII_rpt1	192..251	CDD:410350	21/58 (36%)
		C1_DGK_typeII_rpt2	268..321	CDD:410402	14/52 (27%)
		DAGKc	355..477	CDD:214487	59/121 (49%)
		DAGKa	1478..1635	CDD:214486	63/192 (33%)
		SAM_DGK-delta-eta	1869..1933	CDD:188906