DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgk and LOC567728

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	XP_021334575.1	Gene:	LOC567728 / 567728	-ID:	-	Length:	893	Species:	Danio rerio

Alignment Length:	1250	Identity:	444/1250 - (35%)
Similarity:	592/1250 - (47%)	Gaps:	402/1250 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WDKLSPREFLQLQELASYSTRKLQDVLREFSSPSAAS--TPKCIPD---GDIDFDGFRRFLDAFL 69
            |..|||.||.|||:.:.||::||:|||.||......|  .|:...|   ..||::||:.|:..:|
Zfish     4 WVCLSPAEFSQLQQYSEYSSKKLKDVLEEFHGNGVLSKYNPEQKQDVLNQPIDYEGFQLFMTTYL 68

  Fly    70 DCEAPLDLAKHLFVSFL-------KPNVTQAQ---LHGRALNQMAAISSTAACAPVTSHTKGSIP 124
            :.:.|.:|.||||.||.       .|:.::|.   |..::::...:|.:..||||:|.....||
Zfish    69 ENDIPEELCKHLFTSFKSKNGGEGSPDTSRAGAGILEPKSIDAGISIQTEVACAPITGMNGKSI- 132

  Fly   125 NINSIAELMPQCSGGGGGIGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPSKTG 189
                ::.:....:....||  |.|.........:|||          ......|||....|.::.
Zfish   133 ----LSAMSRHTAESSAGI--TPGSGATTSPCSSRSS----------SQRSGTGGHTPRGPHRSP 181

  Fly   190 SVHPMLTVTPSPLASGPSMFQASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDAVSR 254
            ...|......|..::..::.:.||        ||..|...:...:|.|.::|.
Zfish   182 GTQPKPPTGSSSSSNALALSKTSN--------SPRLSPERNQSENRTSLRRSP------------ 226

  Fly   255 ILPAIGRHCPGSLESGSAQAEKRADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLE 319
                       |.:.||                    |....|.|||:||||||||.|.||||||
Zfish   227 -----------SPQKGS--------------------PSPQVVFLKDIVCYLSLLERGTPEDKLE 260

  Fly   320 FMFRLYDTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQ 384
            |||||||||.||:||::|:|.|:|||:.|||||.||.:||||||:|||.|||||.||||:|:||.
Zfish   261 FMFRLYDTDGNGLLDSSELDRIINQMVHVAEYLEWDSTELRPILKEMMEEIDYDRDGTVTLEEWI 325

  Fly   385 RGGMTTIPLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHE 449
            ||||||||||||||:: |.::|||.|:|:||||:||||||.|..||:|:.|:||||.||||||||
Zfish   326 RGGMTTIPLLVLLGME-TNVQEDGQHIWKLKHFNKPAYCNYCHTMLLGVRKQGLCCALCKYTVHE 389

  Fly   450 RCVQHAPASCITTYVKSKKPKCGGDLLHHWVEGNCYGRCSKCRKRIKAYHGITGLTCRWCHMMLH 514
            |||....|.||:||.||::..  ..:.|.|:|||...:|.||.:.||.|.|:|||.|.||.:.||
Zfish   390 RCVSKDIAPCISTYAKSRRHT--NAMQHVWMEGNSSAKCDKCHRSIKCYQGLTGLHCVWCQITLH 452

  Fly   515 NRCASSVKKECTLGEYSELIVPPTAICPAVLDRQRSVNQAHKATHFQITPPDELSC--------- 570
            |:|||::|.||..|...:..:.|:.|||.||||..:|.:....:....:|.|...|
Zfish   453 NKCASNMKPECDGGPLRDHTLLPSYICPVVLDRHSAVKRGEGESSPSTSPEDTGQCFKFTGDGQA 517

  Fly   571 ----------PLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVI 625
                      ||||.||||||||||:|:||||||:|||||||.|.:|||..||..|:|:|.|||:
Zfish   518 LQITPLPGTHPLLVLVNPKSGGRQGERVLRKFQYLLNPRQVYSLERGGPMAGLNFFRDVPDFRVL 582

  Fly   626 CCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRASTV 690
            .|||||:|||:|:.:|....|..|.:.::||||||||||||||||||||.::.|.:.....::.|
Zfish   583 ACGGDGSVGWILDCIDKASFARHPPVAILPLGTGNDLARCLRWGGGYEGGSLVKFLRDIEHSTEV 647

  Fly   691 MLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTA 755
            :||||:|::
Zfish   648 LLDRWNIDI-------------------------------------------------------- 656

  Fly   756 ASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNT 820

Zfish   657 ----------------------------------------------------------------- 656

  Fly   821 SSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGV 885
                                          ||
Zfish   657 ------------------------------VP--------------------------------- 658

  Fly   886 TSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGN 950
                                                              ||....||
Zfish   659 --------------------------------------------------DDKEEKGD------- 666

  Fly   951 SIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAA 1015
                                                           .|||:|:|||||:||||:
Zfish   667 -----------------------------------------------PVPYSIVNNYFSIGVDAS 684

  Fly  1016 ICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQG 1080
            |..:|||.|||:|.||||||||||||||:.|:||.:|:||.|:|:||:.|||:.|||:: ..|:|
Zfish   685 IAHRFHLMREKHPEKFNSRMKNKLWYFEFGTTETISATCKKLNETIEVECDGIILDLSS-TSLEG 748

  Fly  1081 VALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDR 1145
            :|:||||..|||||||||...::...:      .|||:  .::...:|..::.:|...:||..|:
Zfish   749 IAVLNIPSMHGGSNLWGETKKRRNYNR------MSKKV--PERMTGSTVTDAKELKFCVQDLSDQ 805

  Fly  1146 LIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQV 1210
            |:||:|||..:.|||:.|||:::||||||||.|.|:|.:..|||||||||||.||||::||||||
Zfish   806 LLEVVGLEGAIEMGQIYTGLKSAGRRLAQCSNVTIRTSRLLPMQIDGEPWMQPPCTIRITHKNQV 870

  Fly  1211 PMLMAPRSEKGRGFF 1225
            |||:.|..:....||
Zfish   871 PMLLGPPQKTPFFFF 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199	83/317 (26%)
		EFh	317..386	CDD:238008	50/68 (74%)
		EF-hand_7	318..382	CDD:290234	47/63 (75%)
		C1	410..459	CDD:237996	33/48 (69%)
		C1_1	477..528	CDD:278556	27/50 (54%)
		DAGKc	573..694	CDD:214487	73/120 (61%)
		DAGKa	1003..1194	CDD:214486	101/190 (53%)
LOC567728	XP_021334575.1	DAG_kinase_N	4..93	CDD:316983	35/88 (40%)
		Herpes_BLLF1	<106..>237	CDD:330317	33/198 (17%)
		EFh	258..327	CDD:238008	50/68 (74%)
		C1	350..399	CDD:237996	33/48 (69%)
		C1_1	415..466	CDD:278556	27/50 (54%)
		DAGKc	530..651	CDD:214487	73/120 (61%)
		DAGKa	672..854	CDD:214486	101/190 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	213	1.000	Domainoid score	I2693
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	586	1.000	Inparanoid score	I958
OMA	1	1.010	-	-		QHG47969
OrthoDB	1	1.010	-	-		D633642at2759
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	1	1.000	-	-		otm25085
orthoMCL	1	0.900	-	-		OOG6_102301
Panther	1	1.100	-	-	LDO	PTHR11255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X838
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980