Protein Alignment Dgk and si:dkey-172j4.3

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: XP_009301401.1
• Gene: si:dkey-172j4.3 / 565122
• ZFINID: ZDB-GENE-081104-24
• Length: 1100
• Species: Danio rerio
• Alignment Length: 1067
• Identity: 277/1067 - (25%)
• Similarity: 446/1067 - (41%)
• Gaps: 235/1067 - (22%)

  Fly   190 SVHPML-TVTPSPLASGPSMFQASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDAVS 253
            |.:|:| ||..|..  .|::.....|........|...|.:.|..|....:::|:.:..|:..
Zfish    18 SENPVLCTVMASKF--NPNVLYVREPQESLTSPDPQVEAGDESSDSDGEPEETSHKLIRKVST-- 78

  Fly   254 RILPAIGRHCPGSLESGSAQAEKRADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGR----P 314
                           ||..:|:|.....||.::.|.|.....:        |..|  .||    .
Zfish    79 ---------------SGQIRAKKSVKEGLLLKQTSSFQRWKRR--------YFKL--RGRTLYYA 118

  Fly   315 EDKLEFMFRLYDTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVS 379
            :|....:|...|.....|.:|:..:  :|....|          :.|..:.|:.     |:....
Zfish   119 KDSKSLIFDEVDLSDASVAETSTKN--INNSFTV----------ITPFRKLMLC-----AESRKE 166

  Fly   380 LDEWQRGGMTTIPLLVLLGVDSTTLKE---------DGIHVWRLKHFSKPAYCNLCLNMLVGLGK 435
            :::|         :..|..|......|         .|:|.|.....::|.:||:|...|.|:..
Zfish   167 MEDW---------ISALKSVQKWETYEASQFNMEHFSGMHNWYACSHARPTFCNVCREALPGVTS 222

  Fly   436 KGLCCVLCKYTVHERCVQHAPASCITTYVKSKKPKCGGDLL---------HHWVEGN--CYGRCS 489
            .||.|.:||:..|:||...:..:|..|.:.|    .|.|::         |.|:|||  ...:|.
Zfish   223 HGLSCEVCKFKAHKRCAVRSTNTCKWTTLAS----IGNDIIEDEDGVSMPHQWLEGNLPVSAKCV 283

  Fly   490 KCRKRIKAYHGITGLTCRWCHMMLHNRCASSVKKECTLGEYSELIVPPTAICPAVLDRQRSVNQA 554
            .|.:...:...:....|.||..::||.|...:.|.|.||:....|:||||:           |..
Zfish   284 VCDRNCGSVRRLQDWRCLWCKAIVHNSCKEQLGKVCPLGQCKVSIIPPTAL-----------NSI 337

  Fly   555 HKATHFQITPPDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDL 619
            .....::.|.| ..|.||||.||.|||..||.:.||:|:.:|||.||:||..|||:.||.||:..
Zfish   338 DSDGFWKATSP-SCSSPLLVLVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPQLGLRLFQKF 401

  Fly   620 PRFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGE-NIPKLMDK 683
            ..||.:.|||||:|||||..:|.:.|..|..:||:||||||||||.|.|||..:.: .:.::::|
Zfish   402 ETFRTLVCGGDGSVGWVLSELDKLSLHKQCQLGVLPLGTGNDLARVLGWGGLCDDDAQLLQILEK 466

  Fly   684 FRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQV 748
            ..||:|.||||||:.....|                  .:.:.::|.|....:...:|.:.:..|
Zfish   467 LERATTKMLDRWSVMTYEVP------------------TKQTPAIVKDDDPSDSPLQITQYADSV 513

  Fly   749 ATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAM 813
            ||.:      |.|:.:.|   ..:.:::.:|...|.........|:...:|
Zfish   514 ATHL------TKILDSDK---HSDVISSAKFLCGTVNDFVAEVGKAYERAT-------------- 555

  Fly   814 SSSSSNTSSGSPC---NGNQDAETEVDSHAAAAADVREKSVPRRSGETEK----QSLETLLLQH- 870
            .:.....:....|   |...|:..:..|..|.|..|...|:.....:|::    :|.|.|:|:.
Zfish   556 ENKEEADAMAKKCAMLNEKLDSLVKALSEDANAQLVPAGSISPDDSDTDQSRPFRSREQLMLRAN 620

  Fly   871 --KQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDE 933
              |:.::|...|.::.|                      .::|:...:.:...|.|:.....||.
Zfish   621 SLKKALRQIIDQAEKVV----------------------DEQNRHTQVQRMSSTSSIKRGSSEDL 663

  Fly   934 PKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCT 998
            .:         .::..|::..|..|||......:..:||..::             .||..:.|
Zfish   664 KE---------AETRQNTLSPTATTPILLEKSESFGTVLFSEE-------------SVQCTEKC- 705

  Fly   999 VPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEI 1063
                ::||||.:|:||.|.::|:.:|::||.|.:||.||.:||....|.|....:.|||.:.:::
Zfish   706 ----VMNNYFGIGLDAKISLEFNNKRDENPKKCSSRTKNMMWYGVLGTKELVQKTYKNLEQRVQL 766

  Fly  1064 VCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSAT 1128
            .||||::.|   |.|||:|:||||...||.|.||               |..:     |..|.|.
Zfish   767 ECDGVSMSL---PSLQGLAVLNIPSYAGGINFWG---------------GTKE-----DNNFGAP 808

  Fly  1129 SFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEV--IIKTKKTFPMQID 1191
            ||:            |:.:||:.:...:.|...|. :.....|:|||.:|  .|...:..|:|:|
Zfish   809 SFD------------DKKLEVVAVFGSMQMAMSRV-INIQHHRIAQCRQVKITILGDEGVPVQVD 860

  Fly  1192 GEPWMQMPCTIKVTHKNQVPMLMAPRS 1218
            ||.|:|.|..:::.|||:..||...|:
Zfish   861 GEAWIQPPGIVQIVHKNRAQMLTRDRA 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008	10/68 (15%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	21/73 (29%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	15/52 (29%)
		DAGKc	573..694	CDD:214487	63/121 (52%)
		DAGKa	1003..1194	CDD:214486	64/192 (33%)
si:dkey-172j4.3	XP_009301401.1	PH_DGK_type2	88..184	CDD:270093	21/131 (16%)
		C1	168..253	CDD:412127	23/93 (25%)
		C1	264..325	CDD:412127	17/60 (28%)
		DAGKc	355..477	CDD:214487	63/121 (52%)
		DAGKa	706..863	CDD:214486	64/192 (33%)