Protein Alignment Dgk and Dgke

DIOPT Version :9

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: NP_062378.1
• Gene: Dgke / 56077
• MGIID: 1889276
• Length: 564
• Species: Mus musculus
• Alignment Length: 830
• Identity: 191/830 - (23%)
• Similarity: 277/830 - (33%)
• Gaps: 373/830 - (44%)

  Fly   410 HVWR-LKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITTYVKSKKPKCGG 473
            |.|| ...||.|.||.:|...::    :|..|..|...|.|.|::..........:..|..|...
Mouse    58 HCWRDTDLFSHPTYCCVCAQHIL----QGAFCDCCGLRVDEGCLKKVDKRFPCKEIMLKNDKAAD 118

  Fly   474 DLLHHWVEGN---CYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRC-ASSVKKE-CTLGEYSEL 533
            .:.|||:.||   | ..|..||::..:...:....|.||...:|:.| ..|::.| |..||:..|
Mouse   119 AMPHHWIRGNVPLC-SYCVFCRQQCGSQPKLCDYRCIWCQKTVHDECMRGSLRSEKCDFGEFRNL 182

  Fly   534 IVPPTAICPAVLDRQRSVNQAHK---------ATHF--QITPPDELSCPLLVFVNPKSGGRQGDR 587
            |:||:.:        .|:||..|         |:.|  |.|       ||::..|.:||...|:.
Mouse   183 IIPPSYL--------TSINQMRKDKNTNYEGLASKFGKQWT-------PLIILANSRSGTNMGEG 232

  Fly   588 ILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRF--RVICCGGDGTVGWVLEAMDSIELASQ-- 648
            :|.:|:.:|||.||:|::|..|.:.|.|...||.:  ||:.|||||||||||:|:|.:::..|
Mouse   233 LLGEFKILLNPVQVFDVTKTPPIKALQLCTLLPYYSVRVLVCGGDGTVGWVLDAIDEMKIKGQEK 297

  Fly   649 --PAIGVIPLGTGNDLARCLRWGGGYEGENIP--KLMDKFRRASTVMLDRWSIEVTNTPHSDDMR 709
              |.:.|:||||||||:..|.||.||.|| ||  :::.....|..:.||||.::|||..:.:..:
Mouse   298 YIPEVAVLPLGTGNDLSNTLGWGTGYAGE-IPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRK 361

  Fly   710 PKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETM 774
            ||
Mouse   362 PK--------------------------------------------------------------- 363

  Fly   775 ATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSH 839
               ||
Mouse   364 ---EF------------------------------------------------------------ 365

  Fly   840 AAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQS 904
                                                                             
Mouse   366 ----------------------------------------------------------------- 365

  Fly   905 DNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAAS 969
                                                                             
Mouse   366 ----------------------------------------------------------------- 365

  Fly   970 SVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSR 1034
                                             .:|||||||.||.:.:.||..|||.|..|:||
Mouse   366 ---------------------------------TMNNYFSVGPDALMALNFHAHREKAPSLFSSR 397

  Fly  1035 MKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEH 1099
            :.||..|..|.|.:.....||:|::.||:..||..::|   |:|:|:.:|||.|..||..|| |.
Mouse   398 ILNKAVYLFYGTKDCLVQECKDLNKKIELELDGERVEL---PNLEGIIVLNIGYWGGGCRLW-EG 458

  Fly  1100 LSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTG 1164
            :                    ||:.:          .:|..|  |.|:|::|:....|..|::..
Mouse   459 M--------------------GDETY----------PLARHD--DGLLEIVGVYGSFHCAQIQVK 491

  Fly  1165 LRASGRRLAQCSEVIIKTK-KTFPMQIDGEPWMQMPCTIKVTHKNQVPML 1213
            | |:..|:.|...|.:..| ...|||:|||||.|.|||:.:|||....||
Mouse   492 L-ANPFRIGQAHTVRLTLKCSMMPMQVDGEPWAQGPCTVTITHKTHALML 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199
		EFh	317..386	CDD:238008
		EF-hand_7	318..382	CDD:290234
		C1	410..459	CDD:237996	15/49 (31%)
		C1_1	477..528	CDD:278556	17/55 (31%)
		DAGKc	573..694	CDD:214487	55/128 (43%)
		DAGKa	1003..1194	CDD:214486	64/191 (34%)
Dgke	NP_062378.1	C1_1	58..107	CDD:278556	15/52 (29%)
		C1	122..166	CDD:237996	14/44 (32%)
		TIGR00147	216..526	CDD:161732	135/636 (21%)
		DAGKc	218..346	CDD:214487	55/128 (43%)
		DAGKa	366..521	CDD:214486	64/191 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910