DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgk and PRKCA

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	NP_002728.2	Gene:	PRKCA / 5578	HGNCID:	9393	Length:	672	Species:	Homo sapiens

Alignment Length:	442	Identity:	94/442 - (21%)
Similarity:	146/442 - (33%)	Gaps:	149/442 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 VLLGVDST-------------TLKEDGIHVWR-----LKHFSKPAYCNLCLNMLVGLGKKGLCCV 441
            |..|.|||             .|::..:|..:     .:.|.:|.:|:.|.:.:.|.||:|..|.
Human     4 VFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQ 68

  Fly   442 LCKYTVHERCVQHAPASCITTYVKSKKPKCGGDLLHHWVEGNCYGR---CSKCRKRIKAYHGI-- 501
            :|.:.||:||.:....||...   .|.|........|..:.:.||.   |..|...:   :|:
Human    69 VCCFVVHKRCHEFVTFSCPGA---DKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLL---YGLIH 127

  Fly   502 TGLTCRWCHMMLHNRCASSVKKECTLGE-------YSELIVPPTAICPAVLDRQRSVNQAHKATH 559
            .|:.|..|.|.:|.:|..:|...|.:..       |.:..|....:...|.|.:..:..
Human   128 QGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPM------ 186

  Fly   560 FQITPPDELSCP---LLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLP- 620
                .|:.||.|   |.:..:||:..:|..:.:|.   .|||:.         .|..| ||..|
Human   187 ----DPNGLSDPYVKLKLIPDPKNESKQKTKTIRS---TLNPQW---------NESFT-FKLKPS 234

  Fly   621 ----RFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWG----------GG 671
                |..|.....|.|                         |.||....|.:|          |.
Human   235 DKDRRLSVEIWDWDRT-------------------------TRNDFMGSLSFGVSELMKMPASGW 274

  Fly   672 Y------EGE--NIP----------KLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNM 718
            |      |||  |:|          :|..||.:|.........|    :|..|..:|...|  :.
Human   275 YKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVI----SPSEDRKQPSNNL--DR 333

  Fly   719 QKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETE 770
            .|:.:.:..:|:.|.                 |.|      .:|:|.:..||
Human   334 VKLTDFNFLMVLGKG-----------------SFG------KVMLADRKGTE 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199
		EFh	317..386	CDD:238008
		EF-hand_7	318..382	CDD:290234
		C1	410..459	CDD:237996	15/53 (28%)
		C1_1	477..528	CDD:278556	14/55 (25%)
		DAGKc	573..694	CDD:214487	32/153 (21%)
		DAGKa	1003..1194	CDD:214486
PRKCA	NP_002728.2	C1_1	37..89	CDD:278556	16/51 (31%)
		C1_1	102..154	CDD:278556	14/54 (26%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	36/177 (20%)
		STKc_cPKC_alpha	328..668	CDD:270766	10/60 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0696
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810