DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgk and Dgkb

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	XP_008762871.2	Gene:	Dgkb / 54248	RGDID:	2488	Length:	803	Species:	Rattus norvegicus

Alignment Length:	1269	Identity:	462/1269 - (36%)
Similarity:	569/1269 - (44%)	Gaps:	529/1269 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KWDKLSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDG-------DIDFDGFRRFLD 66
            ||..|||.||.|||:.|.|||:||:|||.||......:  |..|:|       .|||:||:.|:.
  Rat     6 KWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLA--KYNPEGKQDILNQTIDFEGFKLFMK 68

  Fly    67 AFLDCEAPLDLAKHLFVSFLKPNVTQAQLHGRALNQMAAISSTAACAPVTSHTKGSIPNINSIAE 131
            .||:.|.|.|...|||:||                              ::....|.||:.|...
  Rat    69 TFLEAELPDDFTAHLFMSF------------------------------SNKFPHSSPNVKSKPA 103

  Fly   132 LMPQCSGGGGGIGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPSKTGSVHPMLT 196
            |:            :||:...:|
  Rat   104 LL------------SGGLRMNKG------------------------------------------ 114

  Fly   197 VTPSPLASGPSMFQASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDAVSRILPAIGR 261
                          |..|.|    |||:::.:                            |.:
  Rat   115 --------------AITPPR----SSPANTCS----------------------------PEV-- 131

  Fly   262 HCPGSLESGSAQAEKRADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLEFMFRLYD 326
                                               :.|||:||||||||.|||||||||||||||
  Rat   132 -----------------------------------IHLKDIVCYLSLLERGRPEDKLEFMFRLYD 161

  Fly   327 TDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMTTI 391
            ||.||.||::|::.|:.|||.|||||.|||:||.|||.|||.|||||.||||||:||.:||||||
  Rat   162 TDGNGFLDSSELENIIGQMMHVAEYLEWDVTELNPILHEMMEEIDYDRDGTVSLEEWIQGGMTTI 226

  Fly   392 PLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAP 456
            |||||||::: .:|:||.||||||||:||||||||||||:|:||:||||..||||||||||..||
  Rat   227 PLLVLLGLEN-NVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAP 290

  Fly   457 ASCITTYVKSKKPKCGGDLLHH-WVEGNCYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASS 520
            .|||.|||||||   ..|::|| ||||||..:|.||.|.:|.|.|:|||.|.||...|||:|||.
  Rat   291 PSCIKTYVKSKK---NTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQTTLHNKCASH 352

  Fly   521 VKKECTLGEYSELIVPPTAICPAVL------------DRQR-------SVNQAHKATH------- 559
            :|.||..|...:.|:|||.|||.||            :||.       |..|.:|.|.
  Rat   353 LKPECDCGPLKDHILPPTTICPVVLQTMPTAGTSVPEERQSTAKKEKGSSQQPNKVTDKNKMQRA 417

  Fly   560 ---------FQITP-PDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLT 614
                     .|||| |.  :.||||||||||||:||:||.|||||:|||||||.||..||..||.
  Rat   418 NSVTMDGQGLQITPIPG--THPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLH 480

  Fly   615 LFKDLPRFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPK 679
            .|:|:|.|||:.|||||||||:|:.::...:...|.:.::||||||||||||||||||||||:.|
  Rat   481 FFRDVPDFRVLACGGDGTVGWILDCIEKANVVKHPPVAILPLGTGNDLARCLRWGGGYEGENLMK 545

  Fly   680 LMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQ 744
            ::.....::.:|||||..||  ||:..|
  Rat   546 ILKDIESSTEIMLDRWKFEV--TPNDKD------------------------------------- 571

  Fly   745 SKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTL 809

  Rat   572 ----------------------------------------------------------------- 571

  Fly   810 RTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQM 874
                                                  ||..|
  Rat   572 --------------------------------------EKGDP---------------------- 576

  Fly   875 QQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGG 939

  Rat   577 ----------------------------------------------------------------- 576

  Fly   940 GAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNII 1004
                                                                       |||:||
  Rat   577 -----------------------------------------------------------VPYSII 582

  Fly  1005 NNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVA 1069
            |||||:||||:|..:||:.|||:|.|||||||||.||||:.|||||:|:||.||||:||.||||.
  Rat   583 NNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQ 647

  Fly  1070 LDLANGPHLQGVALLNIPYTHGGSNLWGE---HLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFN 1131
            :||.| ..|:|:|:||||..|||||||||   ..|.:||.|           :..||..:.|  :
  Rat   648 IDLIN-ISLEGIAILNIPSMHGGSNLWGESKKKRSHRRIEK-----------KGSDKRPTLT--D 698

  Fly  1132 SVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWM 1196
            :.:|..|.||..|:|:||:|||..:.|||:.|||:::||||||||.|:|:|.|:.||||||||||
  Rat   699 AKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWM 763

  Fly  1197 QMPCTIKVTHKNQVPMLMAPRSEKGRGFFNLLCS 1230
            |.|||||:|||||.||||.|..:.|     |.||
  Rat   764 QTPCTIKITHKNQAPMLMGPPPKTG-----LFCS 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199	66/310 (21%)
		EFh	317..386	CDD:238008	50/68 (74%)
		EF-hand_7	318..382	CDD:290234	47/63 (75%)
		C1	410..459	CDD:237996	39/48 (81%)
		C1_1	477..528	CDD:278556	30/51 (59%)
		DAGKc	573..694	CDD:214487	74/120 (62%)
		DAGKa	1003..1194	CDD:214486	110/193 (57%)
Dgkb	XP_008762871.2	DAG_kinase_N	6..148	CDD:405237	66/310 (21%)
		EFh	152..221	CDD:238008	50/68 (74%)
		C1_DGKbeta_rpt1	237..302	CDD:410395	50/64 (78%)
		C1_DGKbeta_rpt2	307..365	CDD:410441	31/57 (54%)
		DAGKc	439..560	CDD:214487	74/120 (62%)
		DAGKa	581..761	CDD:214486	110/193 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2496
eggNOG	1	0.900	-	-		E1_KOG1169
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37875
Inparanoid	1	1.050	532	1.000	Inparanoid score	I1172
OMA	1	1.010	-	-		QHG47969
OrthoDB	1	1.010	-	-		D633642at2759
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	1	1.000	-	-		otm45738
orthoMCL	1	0.900	-	-		OOG6_102301
Panther	1	1.100	-	-	O	PTHR11255
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X838
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880