Protein Alignment Dgk and Dgke

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: NP_001381287.1
• Gene: Dgke / 497978
• RGDID: 1560914
• Length: 567
• Species: Rattus norvegicus
• Alignment Length: 827
• Identity: 190/827 - (22%)
• Similarity: 276/827 - (33%)
• Gaps: 364/827 - (44%)

  Fly   410 HVWR-LKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITTYVKSKKPKCGG 473
            |.|| ...||.|.||.:|...::    :|..|..|...|.|.|::..........:..|......
  Rat    58 HCWRDTDLFSHPTYCCVCAQHIL----QGAFCDCCGLRVDEGCLKKVDKRFPCKEIMLKNDSRAA 118

  Fly   474 DLL-HHWVEGN---C-YGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRC-ASSVKKE-CTLGEYS 531
            |.: |||:.||   | |  |..||::..:...:....|.||...:|:.| ..|:|.| |..||:.
  Rat   119 DAMPHHWIRGNVPLCTY--CVICRQQCGSQPKLCDYRCVWCQQTVHDECMRGSLKSEKCDFGEFK 181

  Fly   532 ELIVPPTAICPAVLDRQRSVNQAH--KATHFQITPP--DELSCPLLVFVNPKSGGRQGDRILRKF 592
            .||:||:.:        .|:||..  |.|::::...  .:...||::..|.:||...|:.:|.:|
  Rat   182 NLIIPPSYL--------TSINQMRKDKNTNYEVLASKFGKQWTPLIILANSRSGTNMGEGLLGEF 238

  Fly   593 QYMLNPRQVYDLSKGGPKEGLTLFKDLPRF--RVICCGGDGTVGWVLEAMDSIELASQ----PAI 651
            :.:|||.||:|::|..|.:.|.|...||.:  ||:.|||||||||||:|:|.:::..|    |.:
  Rat   239 KMLLNPVQVFDVTKTPPIKALQLCTLLPYYSVRVLVCGGDGTVGWVLDAIDEMKIKGQEKYIPEV 303

  Fly   652 GVIPLGTGNDLARCLRWGGGYEGENIP--KLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTL 714
            .|:||||||||:..|.||.||.|| ||  :::.....|..:.||||.::|||..:....:||
  Rat   304 AVLPLGTGNDLSNTLGWGTGYAGE-IPVAQVLRNVMEADGIKLDRWKVQVTNKGYYSLRKPK--- 364

  Fly   715 HSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEF 779
                                                                           ||
  Rat   365 ---------------------------------------------------------------EF 366

  Fly   780 GSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAA 844
                                                                             
  Rat   367 ----------------------------------------------------------------- 366

  Fly   845 DVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQ 909
                                                                             
  Rat   367 ----------------------------------------------------------------- 366

  Fly   910 RNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQ 974
                                                                             
  Rat   367 ----------------------------------------------------------------- 366

  Fly   975 QQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKL 1039
                                        .:|||||:|.||.:.:.||..|||.|..|:||:.||.
  Rat   367 ----------------------------TMNNYFSIGPDALMALNFHAHREKAPSLFSSRILNKA 403

  Fly  1040 WYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKR 1104
            .|..|.|.:.....||:|::.||:..||..::|   |:|:||.:|||.|..||..||.
  Rat   404 VYLFYGTRDCLVQECKDLNKKIELELDGERVEL---PNLEGVIVLNIGYWGGGCRLWE------- 458

  Fly  1105 IRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASG 1169
                          ..||:.:          .:|..|  |.|:||:|:....|..|::..| |:.
  Rat   459 --------------GVGDETY----------PLARHD--DGLLEVVGVYGSFHCAQIQVKL-ANP 496

  Fly  1170 RRLAQCSEVIIKTK---KTFPMQIDGEPWMQMPCTIKVTHKNQVPML 1213
            .|:.|...|.:..|   ...|||:|||||.|.|||:.:|||....||
  Rat   497 FRIGQAHTVRLTLKCSRMPMPMQVDGEPWAQGPCTVTITHKTHALML 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008
		C1_DGKbeta_rpt1	403..468	CDD:410395	15/58 (26%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	19/56 (34%)
		DAGKc	573..694	CDD:214487	55/128 (43%)
		DAGKa	1003..1194	CDD:214486	64/193 (33%)
Dgke	NP_001381287.1	C1_DGKepsilon_typeIII_rpt1	55..108	CDD:410351	15/53 (28%)
		C1_DGKepsilon_typeIII_rpt2	123..187	CDD:410403	23/65 (35%)
		DAGKc	219..347	CDD:214487	55/128 (43%)
		DAGKa	367..524	CDD:214486	64/193 (33%)