Protein Alignment Dgk and unc-13

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: NP_001245427.1
• Gene: unc-13 / 43841
• FlyBaseID: FBgn0025726
• Length: 3186
• Species: Drosophila melanogaster
• Alignment Length: 879
• Identity: 165/879 - (18%)
• Similarity: 285/879 - (32%)
• Gaps: 260/879 - (29%)

  Fly   105 AISSTAAC-------APVTSHTKGSIP-----NINSIAELMPQCSGGGGGIGGTGGVAGAEGHAQ 157
            |.||:::|       .|:...|:.|:.     :|::.:|...:.||               ....
  Fly  1753 ATSSSSSCHSENECNTPLGQCTQKSVAEKDTNDISNKSEASSETSG---------------PDTP 1802

  Fly   158 ARSSFVDKIHGITDKLHHSLGGHLSHDPSKTGSVHPMLTVTPSPLASGPSMFQASNPARRSVDSS 222
            |..|.|| |....:.|....|.::.:....:||   :|.|....|.    .|...:    |:.:.
  Fly  1803 AELSDVD-ISETENGLRADDGQNIDNMRGNSGS---LLKVNRKYLL----QFDVDH----SLINQ 1855

  Fly   223 PSHSATNHSQMSRNSSKKSSNSVNCKIDAVSRILPAIGRHCPGSLESGSAQAEKRADIKLLARKL 287
            |..::..::.|..|.:..|..|.|.:||  |:.|.:...|..||...|:..|...:..|....|
  Fly  1856 PLETSQYNTHMLENITSASIPSQNRQID--SKTLMSQSSHADGSQAVGNETAVGLSSSKWKLLK- 1917

  Fly   288 SHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLEFMFRLYDTDSNG------VLDT----------A 336
                  |||.         ..:|....:||::....:.|.|.||      .|.|          :
  Fly  1918 ------TLKE---------RKIEEKNNQDKIKEDEMIKDRDKNGGGPGEVGLRTNGHPGDNPFYS 1967

  Fly   337 EMDAIVNQMMAVAEYLGWDVSELR---PILQEMMVEIDYDADGTVSLDEWQRGGMTTIPLLVLLG 398
            .:|::.            |:...|   |::.|::::       |::..: :..|:|:       .
  Fly  1968 NIDSMP------------DIRPRRKSIPLVSELVLK-------TMAATK-RNAGLTS-------A 2005

  Fly   399 VDSTTLKEDGI--HVWR-------------------LKHFSKPAYCNLCLNMLVGLGKKGLCCVL 442
            |...||.::.:  ||::                   |...:.|.||..|..:|.|:.::|:.|..
  Fly  2006 VPRATLNDEDLKMHVYKKALQALIYPISSTTPHNFLLWTATSPTYCYECEGLLWGIARQGVRCTE 2070

  Fly   443 CKYTVHERCVQHAPASCITTYV-KSKKPKCGGDLLHHWVEGNCYGRCSKCRKRIKAYHGITGLTC 506
            |....||:|.....|.|:.... ||.|         |..|.......:..:.|:|
  Fly  2071 CGVKCHEKCKDLLNADCLQRAAEKSSK---------HGAEDKANSIITAMKDRMK---------- 2116

  Fly   507 RWCHMMLHNRCASSVKKECTLGEYSELIVPPTAICPAVLDRQRSVNQAHKATHFQITPPDELS-- 569
                           ::|....|..|||       .||.    ||.:...|.|.:......|.
  Fly  2117 ---------------QREREKPEIFELI-------RAVF----SVEEKSHAGHMKAVKQSVLDGT 2155

  Fly   570 ------------CPLLVFVNPKSGGR------QGDRILRKFQYM---LNPRQVYDLSKGGPKEGL 613
                        |...:....|||..      |..::.::.:.|   |||  |::     .|...
  Fly  2156 SKWSAKIAITVICAQGLIAKDKSGTSDPYVTVQVSKVKKRTRTMPQELNP--VWN-----EKFHF 2213

  Fly   614 TLFKDLPRFRVICCGGDGTVGWVLE---AMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGE 675
            .......|.:|.....|..:...|.   ..:|.:...|..|.|..|....|:     |      .
  Fly  2214 ECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMDV-----W------Y 2267

  Fly   676 NIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVT-LHSNMQKVI----------------- 722
            |:.|..||...:..:.| ..|:|:...........:.| ||.|:...:
  Fly  2268 NLEKRTDKSAVSGAIRL-HISVEIKGEEKVAPYHVQYTCLHENLFHYLCEENTGMVKLPTQKGDD 2331

  Fly   723 -------ELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMAT--ME 778
                   |:.:.:|.:.|:....|.|.    |..|.....::.   .:.......|.|:..  ..
  Fly  2332 AWKLYFDEIPEEIVDEFSMRYGIENIY----QAMTHFHCLSAK---YLCPGVPAVMSTLLANINA 2389

  Fly   779 FGSSTTTTNRTTTTKSISMSTFETQ-------CLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEV 836
            :.:.||.::..:.:...:.|.|..:       .|..:||..:|...:|..:.|| ....|.::.|
  Fly  2390 YYAHTTASSAVSASDRFAASNFGKEKFVKLLDQLHNSLRIDLSMYRNNFPASSP-EKLMDLKSTV 2453

  Fly   837 D---SHAAAAADVREKSVPRRSGETEKQSLETLL 867
            |   |.......|:|.|.|.|:....|..::..|
  Fly  2454 DLLTSITFFRMKVQELSSPPRASTVVKDCVKACL 2487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196	5/18 (28%)
		EFh	317..386	CDD:238008	13/87 (15%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	21/86 (24%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	5/50 (10%)
		DAGKc	573..694	CDD:214487	26/132 (20%)
		DAGKa	1003..1194	CDD:214486
unc-13	NP_001245427.1	C1	2019..2100	CDD:412127	21/89 (24%)
		C2B_Munc13	2160..2286	CDD:175993	27/144 (19%)
		MUN	2477..2996	CDD:461870	2/11 (18%)
		C2C_Munc13	3032..3152	CDD:176041