Protein Alignment Dgk and Dgkh

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: XP_036014587.1
• Gene: Dgkh / 380921
• MGIID: 2444188
• Length: 1246
• Species: Mus musculus
• Alignment Length: 1090
• Identity: 293/1090 - (26%)
• Similarity: 468/1090 - (42%)
• Gaps: 218/1090 - (20%)

  Fly   222 SPSHSATNHSQMSRNSSKKSSNSV-NCKIDAVSRILP-AIGRHCPGSLESGSAQAEKRADIKLLA 284
            ||:.......:|:...|:.....| ...:...|.:.| |.|   ||. :|..::||:....||:
Mouse    14 SPAWEEPESERMAGAGSQHHPQGVAGGAVAGASAVSPTAAG---PGE-DSSDSEAEQEGPQKLI- 73

  Fly   285 RKLSHFDPLTLKVPLKD--VVCYLSLLEAGRPEDKLEFMFR----LYDTDSNG-VLDTAEM-DAI 341
            ||:|....:..|..:|:  ::...|..:..:   |..|..|    .|..||.. :.|..:: ||.
Mouse    74 RKVSTSGQMRTKTSIKEGQLLKQTSSFQRWK---KRYFKLRGRTLYYAKDSKSLIFDEVDLSDAS 135

  Fly   342 VNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMTTIPLLVLLGVDSTTLKE 406
            |.:  |..:......:.:.|..:.|:.     |:....::.|         :..|..|.|....|
Mouse   136 VAE--ASTKNANNSFTIITPFRRLMLC-----AENRKEMEVW---------ISSLKSVQSREPYE 184

  Fly   407 ---------DGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITT 462
                     .|:|.|.....::|.:||:|...|.|:...||.|.:||:..|:||...|..:|..|
Mouse   185 VAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWT 249

  Fly   463 YVKSKKPKCGGDLL---------HHWVEGN--CYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNR 516
            .:.|    .|.|::         |.|:|||  ...:|:.|.|...:...:....|.||..|:|..
Mouse   250 TLAS----IGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTA 310

  Fly   517 CASSVKKECTLGEYSELIVPPTAI--------CPAVLDRQRSVNQAHKATHFQITPPDELSCPLL 573
            |.......|.||:....|:||.|:        |.|...             |.::       |||
Mouse   311 CKDVYHPVCPLGQCKVSIIPPIALNSTDSDGFCRATFS-------------FCVS-------PLL 355

  Fly   574 VFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLE 638
            ||||.|||..||.:.||:|:.:|||.||:||..|||..||.||:....||::.|||||:|||||.
Mouse   356 VFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPYLGLRLFQKFDNFRILVCGGDGSVGWVLS 420

  Fly   639 AMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGE-NIPKLMDKFRRASTVMLDRWSIEV--T 700
            .:|.:.|..|..:||:||||||||||.|.|||.|:.: .:|::::|..||||.|||||||..  .
Mouse   421 EIDKLNLHKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYEL 485

  Fly   701 NTPHSDDMRPK---------VTLH-----SNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATS 751
            ..|....:.|:         :|::     :::.|::...:..||
Mouse   486 KLPAKSSLLPEPVAATEEFYMTIYEDSVANHLTKIVNSDEHAVV--------------------- 529

  Fly   752 MGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTA-MSS 815
                .||..|:    .||..:.:|.:|.....|..|........|..:...:.|:|.|:.. ..|
Mouse   530 ----ISSAKIL----CETVKDFVAKVEKAQDRTLENTVVAEAVASKCSVLNEKLEQLLQALHADS 586

  Fly   816 SSSNTSSG-SPCNGNQD-AETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQH--KQQMQQ 876
            .:|....| .|....:| .|:..|.....:.|.....:.:.|.:...:..|.:|..:  |:.::|
Mouse   587 QASRVPPGIGPAIPEEDTVESASDESLGESKDQLVNDIGKPSSQKAVKPREIMLRANSLKKAVRQ 651

  Fly   877 QQQQQQQGVTSLAVEEAATATPV--GSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDD-- 937
            ..::.::.:...||:.:...:|.  ...::|.:.:.:.:.::..:..:.|.|.......|:.|
Mouse   652 VIEEAEKVMDEPAVQPSEPVSPSCDYDTETDEAKEDDAKESLSAKTTSQSPDAQASCGHPQTDSV 716

  Fly   938 GGGAGDGTKSNGNSIPATPATPITP------TTPNAASSVLQQQQQQHLQFEQQQKPIK----VQ 992
            .|.|...||.|   :|......|.|      ....|.||::.:....::.      |..    :.
Mouse   717 AGPAMATTKEN---LPVLNTRIICPGLRAGLAASIAGSSIINKMLLANID------PFGATPFID 772

  Fly   993 SDKDCTVPYN---IINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASC 1054
            .|.|....|:   ::||||.:|:||.|.::|:.:||::|.|..||.||.:||....|.|....|.
Mouse   773 PDLDSLDGYSEKCVMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSY 837

  Fly  1055 KNLHESIEI-----------VCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKS 1108
            |||.:.:::           .|||..:.|   |.|||:|:||||...||:|.||
Mouse   838 KNLEQRVQLEGISFLSSFCDQCDGQYIPL---PSLQGIAVLNIPSYAGGTNFWG----------- 888

  Fly  1109 AGPFGKSKKLRAGDKE---FSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGR 1170
                        |.||   |:|.||:            |:::||:.:.:.:.|...|. ::....
Mouse   889 ------------GTKEDDIFAAPSFD------------DKILEVVAVFDSVQMAVSRV-IKLQHH 928

  Fly  1171 RLAQCS--EVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRS 1218
            |:|||.  ::.|...:..|:|:|||.|:|.|..||:.|||:..||...|:
Mouse   929 RIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRA 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008	15/74 (20%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	22/73 (30%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	15/52 (29%)
		DAGKc	573..694	CDD:214487	67/121 (55%)
		DAGKa	1003..1194	CDD:214486	64/206 (31%)
Dgkh	XP_036014587.1	PH_DGK_type2	88..184	CDD:270093	20/114 (18%)
		C1_DGKeta_rpt1	168..253	CDD:410398	25/93 (27%)
		C1_DGKeta_rpt2	264..325	CDD:410444	17/60 (28%)
		DAGKc	355..477	CDD:214487	67/121 (55%)
		DAGKa	786..954	CDD:214486	64/206 (31%)
		SAM_DGK-eta	1174..1238	CDD:188975