Protein Alignment Dgk and Dgkd

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: NP_001414381.1
• Gene: Dgkd / 368088
• RGDID: 1563309
• Length: 1220
• Species: Rattus norvegicus
• Alignment Length: 1122
• Identity: 297/1122 - (26%)
• Similarity: 460/1122 - (40%)
• Gaps: 266/1122 - (23%)

  Fly   199 PSPLASGPSMFQASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDAVSRILPAIGRHC 263
            |.|   ||.......|...|.||.|.....:..::.|..|  :|..:..|......:|
  Rat     8 PPP---GPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVS--TSGQIRQKTILKEGML------- 60

  Fly   264 PGSLESGSAQAEKRADIKLLARKLSH--------FDPLTLKVPLKDVVCYLSLLEAGRPEDKLEF 320
              :.::.|.|..||...||..|.|.:        ||.:.|
  Rat    61 --TKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDL------------------------- 98

  Fly   321 MFRLYDTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQR 385
                  ||:: |.:::..:  ||....|       ::..|.::        ..||....:::|
  Rat    99 ------TDAS-VAESSTKN--VNNSFTV-------ITPCRKLI--------LCADNRKEMEDW-- 137

  Fly   386 GGMTTIPLLVLLGVDSTTLKE------------DGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGL 438
                      :..:.:...||            .|.|.|.....::|.|||:|..:|.|:...||
  Rat   138 ----------IAALKTVQNKEHFEPTQYSMDHFSGTHNWYACSHARPTYCNVCREVLSGVTSHGL 192

  Fly   439 CCVLCKYTVHERCVQHAPASCITTYVKSKKPKCGGDLL---------HHWVEGN--CYGRCSKCR 492
            .|.:||:..|:||...|.::|..|.:.|    .|.|::         |.|:|||  ...:|..|.
  Rat   193 SCEVCKFKAHKRCAVRATSNCKWTTLAS----IGKDIIEDEDGIAMPHQWLEGNLPVSAKCIVCD 253

  Fly   493 KRIKAYHGITGLTCRWCHMMLHNRCASSVKKECTLGEYSELIVPPTAICPAVLDRQRSVNQAHKA 557
            |...:...:....|.||..|:|..|..|:..:|.||.....::||||:           |.....
  Rat   254 KTCGSVLRLQDWRCLWCKAMVHTSCKESLVMKCPLGLCKVSVIPPTAL-----------NSIDSD 307

  Fly   558 THFQITPPDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRF 622
            ..::.|.|...:.|||||||.|||..||.:.||:|:.:|||.||:||..|||..||.||:....|
  Rat   308 GFWKATCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTF 372

  Fly   623 RVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGE-NIPKLMDKFRR 686
            |::.|||||:|||||..:||:.|..|..:||:||||||||||.|.||...:.: .:|:::.|..|
  Rat   373 RILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILAKLER 437

  Fly   687 ASTVMLDRWSIEV--TNTPH-----------SDDMRPKVTLH------SNMQKVIELSQ-SVVVD 731
            |||.||||||:..  |..|.           |:|...:..|.      :::.|::...| |||:.
  Rat   438 ASTKMLDRWSVMAYETKLPRQASSSTVTEDCSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVIS 502

  Fly   732 --KSLMERFEE-IQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTK 793
              |.|.|..:: :.|..|  |....|.:|..|.:||.|.....|.:.::              .|
  Rat   503 SAKVLCETVKDFVARVGK--AYEKTTESSQESEVMAKKCSVLKEKLDSL--------------LK 551

  Fly   794 SISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSV--PRRSG 856
            ::...:..:..|.....|....:.....||:.|:...|       |...:|......:  ||...
  Rat   552 TLDDESQASSSLSNPPPTIAEEAEDGDGSGNICSSTGD-------HLVGSACPSRPQIFRPREQL 609

  Fly   857 ETEKQSLETL---LLQHKQQM---QQQQQQQQQG-------------------VTSLAVEEAATA 896
            .....||:..   :::|.::.   |..|.|:|||                   .||.|..|:..
  Rat   610 MLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQQGFVLGLSESEKKDLKTDNRVCTSSAHSESCV- 673

  Fly   897 TPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPIT 961
              |...:|...:.|.....::.:    .|.|......|.:.|         :.:|:||.....:.
  Rat   674 --VAKGRSHRKASRTPCEKLMSK----GLSLGSSASLPPNTG---------SRDSLPALNTKILY 723

  Fly   962 PTTPNAAS------SVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKF 1020
            |:.....|      ||:.:.......|..:.:.::..::| |     ::||||.:|:||.|.:.|
  Rat   724 PSVRAGMSGSLPGGSVISRLLINADPFNAEPENLEYYTEK-C-----VMNNYFGIGLDAKISLDF 782

  Fly  1021 HLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLN 1085
            :.:|:::|.|..||.||.:||....|.|....:.:||.:.:.:.|||..:.|   |.|||:|:||
  Rat   783 NNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYRNLEQKVLLECDGRPIPL---PSLQGIAVLN 844

  Fly  1086 IPYTHGGSNLWGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVI 1150
            ||...||:|.||                       |.||         |.:.|...|.|:::||:
  Rat   845 IPSYAGGTNFWG-----------------------GTKE---------DDTFAAPSFDDKILEVV 877

  Fly  1151 GLENCLHMGQVRTGLRASGRRLAQCSEVIIKT--KKTFPMQIDGEPWMQMPCTIKVTHKNQVPML 1213
            .:...:.|...|. ::....|:|||..|.|..  .:..|:|:|||.|:|.|..|::.|||:...|
  Rat   878 AVFGSMQMAVSRV-IKLQHHRIAQCRTVKISILGDEGVPVQVDGEAWIQPPGYIRIVHKNRAQTL 941

  Fly  1214 MAPRSEKGRGFFNLLCS 1230
                 .:.|.|.|.|.|
  Rat   942 -----TRDRAFENTLKS 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008	10/68 (15%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	24/76 (32%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	16/52 (31%)
		DAGKc	573..694	CDD:214487	66/121 (55%)
		DAGKa	1003..1194	CDD:214486	61/192 (32%)
Dgkd	NP_001414381.1	None