DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dgk and Dgkk

DIOPT Version :10

Sequence 1:NP_724619.2 Gene:Dgk / 35738 FlyBaseID:FBgn0085390 Length:1230 Species:Drosophila melanogaster
Sequence 2:XP_038956233.1 Gene:Dgkk / 367745 RGDID:1561510 Length:1385 Species:Rattus norvegicus


Alignment Length:911 Identity:254/911 - (27%)
Similarity:401/911 - (44%) Gaps:206/911 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   356 VSELRPILQEMMVEIDYDADGTVSLDEW-------QRGGMTTI------PLLVLLGVDSTTLKED 407
            ||.:.|..|:|              :||       |:|.:..|      |.|:            
  Rat   398 VSLVAPSRQDM--------------EEWINIIKTVQQGEIRQIPAAENNPFLI------------ 436

  Fly   408 GIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITTYVKSKKPKCG 472
            |:|.|......:..:||:|...:..|.:..:.|.:||...|:.|...|...|     |.......
  Rat   437 GMHYWYSSPNPRTQFCNVCRENIPALSRDAIICEVCKVKSHKVCALRANKDC-----KWNTLSIT 496

  Fly   473 GDLL----------HHWVEGN--CYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSVKKEC 525
            .|||          |.|||||  ...:|:.|.:...:||.:....|.||...:|..|.....|||
  Rat   497 DDLLLPADEIQTMPHQWVEGNIPANSQCTVCHESCGSYHRLQDFRCLWCGSTVHGACQKRFSKEC 561

  Fly   526 TLGEYSELIVPPTAICPAVLDRQRSVNQAHKATHFQITPPDELSCPLLVFVNPKSGGRQGDRILR 590
            :.|....|||||||:.....|.|..|:    :..:.:..|...|||||:|:|.|||..||...||
  Rat   562 SFGSCRSLIVPPTALSDPRGDGQLVVS----SEFWNLDWPLTCSCPLLIFINSKSGDHQGIIFLR 622

  Fly   591 KFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIP 655
            ||:..|||.||:||:||||:.|:.:||:..||||:.|||||:|.|||..:|:..|..:..:.:||
  Rat   623 KFKQYLNPSQVFDLAKGGPEAGIAMFKNFARFRVLVCGGDGSVSWVLSTIDAYGLHDRCQMAIIP 687

  Fly   656 LGTGNDLARCLRWGGGY-EGENIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQ 719
            |||||||||.|.||..: :|::..:::.:..:|...:|||||:.:..||               :
  Rat   688 LGTGNDLARVLGWGAFWSKGKSPLEILSRVEQAHVRILDRWSVMIRETP---------------K 737

  Fly   720 KVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSS-- 782
            .|..|...|.:|   :.|||....::.:.||      :..:.::.:|..||| .:||....|:  
  Rat   738 PVPLLKGQVGMD---IPRFEAAAIKNVESAT------TELNKILKAKYPTEM-VIATRFLCSAVQ 792

  Fly   783 ---------------TTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDA 832
                           .||...:...||..|....:..|......|:::|:..|::........|.
  Rat   793 DFIDDIVKAWHQIKQNTTAVESVILKSDLMYDKLSVLLDLLAEDAVAASAERTATAYGSRSKPDG 857

  Fly   833 ET---EVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAA 894
            :.   |:|..|.|..::.|::      :..:|||:.:|.|.:|.:..:.:|      ||:|:..|
  Rat   858 KAFVPELDHIAKAKMELAERA------QKLQQSLKLILFQVEQVLDDESRQ------SLSVKNFA 910

  Fly   895 TATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATP 959
            ::..:|....|:                     .|::..|:.         :|..:::.:.|:  
  Rat   911 SSLFLGDGDDDS---------------------DDYDQSPRH---------RSRCDTLSSIPS-- 943

  Fly   960 ITPTTPNAASSVLQQQQQQHLQFEQ-QQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLE 1023
                        |:.:...:|..|. ...|..::..:.|     ::||||.:|:||.|.::|:..
  Rat   944 ------------LRSEDLDNLDLEHLHVTPETIRFKERC-----VMNNYFGIGLDAKISLEFNAR 991

  Fly  1024 REKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPY 1088
            ||::|.::|||:|||:||....:.|....|.:.|.|.|.:.|||.|:.|   |:|||:.:|||..
  Rat   992 REEHPEQYNSRLKNKIWYGLLGSKELLQRSYRKLEERIHLECDGEAVSL---PNLQGIVVLNITS 1053

  Fly  1089 THGGSNLWGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLE 1153
            ..||.|.||.:                    ....|:.|.:.:            |..:||:.:.
  Rat  1054 YAGGVNFWGSN--------------------TATTEYEAPAID------------DGKLEVVAIF 1086

  Fly  1154 NCLHMGQVRTGLRASGRRLAQCSEVIIKT--KKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAP 1216
            ..:.|...|. :.....|:|||.||||..  :...|:|:|||.|:|.|..||:.:||...|||..
  Rat  1087 GSVQMAMSRI-INLHHHRIAQCREVIITIDGEGGIPVQVDGEAWIQKPGLIKIKYKNTAQMLMRD 1150

  Fly  1217 R 1217
            |
  Rat  1151 R 1151

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DgkNP_724619.2 DAG_kinase_N 9..117 CDD:464196
EFh 317..386 CDD:238008 8/36 (22%)
C1_DGKbeta_rpt1 403..468 CDD:410395 15/64 (23%)
C1_DGK_typeI_like_rpt2 477..528 CDD:410401 18/52 (35%)
DAGKc 573..694 CDD:214487 58/121 (48%)
DAGKa 1003..1194 CDD:214486 61/192 (32%)
DgkkXP_038956233.1 Trypan_PARP <79..148 CDD:368653
Trypan_PARP <198..292 CDD:368653
PH_DGK_type2 329..423 CDD:270093 9/38 (24%)
C1_DGK_typeII_rpt1 437..494 CDD:410350 15/61 (25%)
C1_DGK_typeII_rpt2 511..564 CDD:410402 18/52 (35%)
DAGKc 605..727 CDD:214487 58/121 (48%)
DAGKa 971..1128 CDD:214486 61/192 (32%)
Blue background indicates that the domain is not in the aligned region.

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