DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgk and Dgkepsilon

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	NP_001286362.1	Gene:	Dgkepsilon / 36408	FlyBaseID:	FBgn0020930	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	865	Identity:	186/865 - (21%)
Similarity:	288/865 - (33%)	Gaps:	366/865 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 GTVSLD-EWQRGGMTTIPLLVLLGVDSTTLKEDGI------HVWR-LKHFSKPAYCNLCLNMLVG 432
            ||:.|. |...|.:  :.|.:|.....:.|.||.:      |.|: :|...:..:||:|..:|.
  Fly     4 GTIELSVEALIGSL--LALSILFAFCRSLLSEDFVSTFKTRHSWKSIKVLEQACFCNVCEILLT- 65

  Fly   433 LGKKGL---CCVLCKYTVHERCVQHAPAS--CITTYVKSKKPKCGGDLLHHWVEGNC-YG-RCSK 490
             ...||   ||.||.:.. ..|.:.|...  |...:::::     ..:.|.||.||. .| .|:.
  Fly    66 -PSAGLFCDCCGLCTHAT-PPCQRRADREYRCKDKWLRNE-----SSVRHLWVHGNLPMGVHCAD 123

  Fly   491 CRKRIKAYH-----GITGLTCRWCHMMLHNRC---ASSVKKECTLGEYSELIVPPTAICPAVLDR 547
            |.:.:. :|     |:.|..|.||....||.|   |.|: :.|.|||:.::|.||.:...|   |
  Fly   124 CNEEVD-HHVSTDPGLYGWRCAWCQRCYHNDCYTRADSM-EACDLGEFKDMIFPPYSFVAA---R 183

  Fly   548 QRSVNQAHKATHFQITPPD-ELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKE 611
            .|...:.|.|:   ||||| |...||:|..|.|||...|..:|...:..|:|.||.:|...||::
  Fly   184 TRDSMRLHLAS---ITPPDIENWEPLIVIANTKSGSSTGANVLSLLRGYLHPLQVMELGSRGPQD 245

  Fly   612 GLT-LFKDLPR-FRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEG 674
            .|. ..|..|| .|::..|||||:||||..:.::.:..||::.::||||||||:|.|.||.....
  Fly   246 ALQWAAKASPRPCRILVAGGDGTIGWVLNTIYTLNIKPQPSVAIMPLGTGNDLSRVLGWGAEPPS 310

  Fly   675 ENIP-KLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERF 738
            ...| |::...|||.:|.|||:.:::..            ||..:
  Fly   311 VLDPVKILRSIRRARSVNLDRFDLQIEK------------LHYRL-------------------- 343

  Fly   739 EEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQ 803
             .|||.                                              .||:|.
  Fly   344 -PIQRH----------------------------------------------PTKTIH------- 354

  Fly   804 CLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLL 868

  Fly   355 ----------------------------------------------------------------- 354

  Fly   869 QHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDE 933

  Fly   355 ----------------------------------------------------------------- 354

  Fly   934 PKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCT 998

  Fly   355 ----------------------------------------------------------------- 354

  Fly   999 VPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEI 1063
                 :.|||||||||.|...||..||...:..:||:.|||.||.:.|.:.....|:::.|.:.:
  Fly   355 -----VYNYFSVGVDAYITYNFHKTRESRFYLLSSRIFNKLLYFTFGTQQVMQPGCEHIEEKLTL 414

  Fly  1064 VCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSAT 1128
            ..|...:.|   |.||.:..|||       :.||                      ||.|....:
  Fly   415 YLDNKPVQL---PELQALVFLNI-------DSWG----------------------AGCKLCELS 447

  Fly  1129 SFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGE 1193
            :.|. ::.: :....|.::||.|:.:..|:.|::..: :...|:.|..::.::.|:|.|||.|||
  Fly   448 NANG-EVRI-VNSISDGMMEVFGIVSSFHIAQLQCNI-SKPVRIGQAKQIRLQVKETVPMQADGE 509

  Fly  1194 PWMQMPCTIKVTHKNQVPML 1213
            ||||.|..|:::.::|..:|
  Fly   510 PWMQSPADIRLSSRSQARVL 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199
		EFh	317..386	CDD:238008	4/10 (40%)
		EF-hand_7	318..382	CDD:290234	3/6 (50%)
		C1	410..459	CDD:237996	15/54 (28%)
		C1_1	477..528	CDD:278556	20/60 (33%)
		DAGKc	573..694	CDD:214487	49/123 (40%)
		DAGKa	1003..1194	CDD:214486	53/190 (28%)
Dgkepsilon	NP_001286362.1	C1_1	108..165	CDD:278556	19/58 (33%)
		LCB5	207..519	CDD:224513	118/632 (19%)
		DAGKc	207..331	CDD:214487	49/123 (40%)
		DAGK_acc	355..510	CDD:279003	53/189 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462336
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1169
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16095at33392
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850