Protein Alignment Dgk and rdgA

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: NP_001259366.1
• Gene: rdgA / 31826
• FlyBaseID: FBgn0261549
• Length: 1462
• Species: Drosophila melanogaster
• Alignment Length: 1342
• Identity: 296/1342 - (22%)
• Similarity: 439/1342 - (32%)
• Gaps: 560/1342 - (41%)

  Fly    22 QELASYSTRKLQDVLREFSSPSAASTPKCIPDGDIDFDGFRRFLDAFLDCEAPLDLAKHLFVSFL 86
            :|..|.:....::...|.::..|...|:...:.:.|.|.         |.:|.|::
  Fly   229 EEEGSAAIEDAEEETTEAATEEADEDPRTEVESEHDHDP---------DDDAALEM--------- 275

  Fly    87 KPNVTQAQLHGRALNQMAAISSTAACAP--VTSHTKGSIPNINSIAELMPQCSGGGGGIGGTGGV 149
                   .:....::|.::|..:.|..|  :..||.|| .::.|.:|                 .
  Fly   276 -------DIRIGNMSQGSSIEESRARLPRQMRRHTIGS-SSVTSASE-----------------D 315

  Fly   150 AGAEGHAQARSSFVDKI--------HGITDKLHHSLGG-----HLSHDP---------SKTGSVH 192
            .|.||.......|.:.:        .|||..|..:.|.     ||..||         |.:|.:.
  Fly   316 EGLEGSDNGSPHFGNTLLPPQPTTPCGITFTLSPTNGDYPSPPHLPLDPGSPPISPCSSNSGRLP 380

  Fly   193 PMLTVTPSPLAS------GPSMFQASNPARRSVD---------SSPSHSATNHSQMSRNSSKKSS 242
            .:..:..:|.:|      |.:|.......|||:.         :..|....:|.::. ||:.|||
  Fly   381 ALAPIISTPCSSADADDAGAAMGLPVRARRRSISRQEAIFVEPTGNSLENVSHEEVD-NSNTKSS 444

  Fly   243 NSVNCKIDAVSRILPAIGRHC--PGSL-ESGSAQAEKRA----DIKLLARKL---------SHFD 291
            ......:|..|.:..     |  ||:. .||::.:...|    ||.|:...|         |.|.
  Fly   445 VDTADSLDEASTMAT-----CGSPGAAGGSGASSSHHNAFVVRDIYLMVPDLKRDRAASVDSCFS 504

  Fly   292 PLTLKVPLKDVV-----CYLSL--LEAGRPEDKLEFMFRLYDTDSNGVLDTAEMDAIVNQMMAVA 349
            .|:.....:::.     |:|::  :.|.|.        |..|.    ||.|.|.          |
  Fly   505 KLSSNAKTEELQPSADGCFLTVPNINATRS--------RSVDI----VLPTDEQ----------A 547

  Fly   350 EYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMTTIPLLVLLGVDSTTLKEDGIHVWRL 414
            .|         ..|......:.| |||..:.....|..:..:|       |.|.....|.|.|
  Fly   548 RY---------KALSMTGSTVTY-ADGRTASASNSRRPIRIVP-------DWTENAVQGEHYW-- 593

  Fly   415 KHFSKPAYCN---LCLNMLVGLGKKGLCCVLCKYTVHERCV----QHAPASCITTY--VKSKKPK 470
                ||...:   .|||.......:.:.|..|:...|..|:    :.:..:|..||  |..::.:
  Fly   594 ----KPTSASGDLCCLNEECIKSGQRMKCSACQLVAHHNCIPFVNEKSTLACKPTYRDVGIRQYR 654

  Fly   471 CGGDLLHHWVEGNC-YGRCSKCRK----------RIKAYHGITGLTCRWCHMMLHNR--CASSVK 522
            ......||||.... .|:|.:|.|          ::.....|..|.|.|||.:.||:  |.:..|
  Fly   655 EQTTTHHHWVHRKLEKGKCKQCGKFFPMKQAVQSKLFGSKEIVALACAWCHEIYHNKEACFNQAK 719

  Fly   523 --KECTLGEYSELIVPPTAIC-----------------------------------------PAV 544
              :||.||.|:.:||||:.|.                                         ...
  Fly   720 IGEECRLGNYAPIIVPPSWIVKLPTKGNFKSSIRVSNKNNAASGSGGGGAGGGAGGGGGKSKKQT 784

  Fly   545 LDRQRSVNQAHKATHFQITP-PDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGG 608
            ..||:...:..:...|.:.| |.....|::||:||||||.||.::|.|||::||||||:||::||
  Fly   785 QRRQKGKEEKKEPRAFIVKPIPSPEVIPVIVFINPKSGGNQGHKLLGKFQHLLNPRQVFDLTQGG 849

  Fly   609 PKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIE--LASQPAIGVIPLGTGNDLARCLRWGG- 670
            ||.||.:|:..|..||:.|||||||||||..:|.|:  |...||:||:||||||||||.|.|||
  Fly   850 PKMGLDMFRKAPNLRVLACGGDGTVGWVLSVLDQIQPPLQPAPAVGVLPLGTGNDLARALGWGGS 914

  Fly   671 ----GYEGENIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVD 731
                ||..|.|.|::.:...:..|::|||.::|  ||:.|                      |.|
  Fly   915 IFFQGYTDEPIGKILREIGMSQCVLMDRWRVKV--TPNDD----------------------VTD 955

  Fly   732 KSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSIS 796
                                                                             
  Fly   956 ----------------------------------------------------------------- 955

  Fly   797 MSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQ 861
                                                                             
  Fly   956 ----------------------------------------------------------------- 955

  Fly   862 SLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLD 926
                                                                             
  Fly   956 ----------------------------------------------------------------- 955

  Fly   927 LSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKV 991
              ||.|..|                             ||
  Fly   956 --DHVDRSK-----------------------------PN------------------------- 964

  Fly   992 QSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKN 1056
                   ||.|:||||||.||||.|.::||..||.:|.:||||::||::|.:....:......:|
  Fly   965 -------VPLNVINNYFSFGVDAHIALEFHEAREAHPERFNSRLRNKMYYGQMGGKDLILRQYRN 1022

  Fly  1057 LHESIEIVCDGVALDLAN-----GPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSK 1116
            |.:.:.:.|||  .|...     |.|  .|..||||...||::.|.:            .||.||
  Fly  1023 LSQWVTLECDG--QDFTGKLRDAGCH--AVLFLNIPSYGGGTHPWND------------SFGASK 1071

  Fly  1117 KLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIK 1181
            .              |:|         |.|:||:|| ....:..::.|:.  |..:.||.:..|.
  Fly  1072 P--------------SID---------DGLMEVVGL-TTYQLPMLQAGMH--GTCICQCRKARII 1110

  Fly  1182 TKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSEKGRG 1223
            ||:|.|||:|||.....|..|::...|:.  ||..:.:.|||
  Fly  1111 TKRTIPMQVDGEACRVKPSVIEIELLNKA--LMLSKRKHGRG 1150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196	14/96 (15%)
		EFh	317..386	CDD:238008	13/68 (19%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	16/73 (22%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	20/65 (31%)
		DAGKc	573..694	CDD:214487	70/127 (55%)
		DAGKa	1003..1194	CDD:214486	64/195 (33%)
rdgA	NP_001259366.1	C1_DGK_typeIV_rpt1	586..647	CDD:410352	15/66 (23%)
		C1_DGK_typeIV_rpt2	661..727	CDD:410405	20/65 (31%)
		DAGKc	814..942	CDD:214487	70/127 (55%)
		DAGKa	969..1123	CDD:214486	64/195 (33%)
		ANKYR	<1329..1452	CDD:440430
		ANK repeat	1329..1356	CDD:293786
		ANK repeat	1358..1391	CDD:293786
		ANK repeat	1393..1425	CDD:293786