DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dgk and Prkcb

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	NP_036845.3	Gene:	Prkcb / 25023	RGDID:	3396	Length:	673	Species:	Rattus norvegicus

Alignment Length:	201	Identity:	49/201 - (24%)
Similarity:	85/201 - (42%)	Gaps:	28/201 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 HVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITTYVKSKKPKCGGD 474
            |.:..:.|.:|.:|:.|.:.:.|||.:|....:|.:.||:||.:....||...   .|.|.....
  Rat    37 HKFTARFFKQPTFCSHCTDFIWGLGLQGFQSQVCCFVVHKRCHEFVTFSCPGA---DKGPASDDP 98

  Fly   475 LLHHWVEGNCYGR---CSKCRKRIKAYHGI--TGLTCRWCHMMLHNRCASSVKKECTLGEYSE-- 532
            ...|..:.:.|..   |..|...:   :|:  .|:.|..|.|.:|.||..:|...|.. :::|
  Rat    99 RSKHKFKIHTYSSPTFCDHCGSLL---YGLIHQGMKCDTCMMNVHKRCVMNVPSLCGT-DHTERR 159

  Fly   533 --LIVPPTAICPAVLDRQRSVNQAHKATHFQITPPDELSCP---LLVFVNPKSGGRQGDRILRKF 592
              :.:      .|.:||:..:.....|.:.....|:.||.|   |.:..:|||..:|..:.::
  Rat   160 GRIYI------QAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIK-- 216

  Fly   593 QYMLNP 598
             ..|||
  Rat   217 -CSLNP 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199
		EFh	317..386	CDD:238008
		EF-hand_7	318..382	CDD:290234
		C1	410..459	CDD:237996	14/48 (29%)
		C1_1	477..528	CDD:278556	14/55 (25%)
		DAGKc	573..694	CDD:214487	7/26 (27%)
		DAGKa	1003..1194	CDD:214486
Prkcb	NP_036845.3	C1_1	37..89	CDD:278556	16/51 (31%)
		C1_1	102..152	CDD:278556	13/52 (25%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	16/72 (22%)
		STKc_cPKC_beta	341..663	CDD:270767
		S_TKc	342..600	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0696
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900