Protein Alignment Dgk and Dgkb

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: XP_006515130.1
• Gene: Dgkb / 217480
• MGIID: 2442474
• Length: 803
• Species: Mus musculus
• Alignment Length: 1269
• Identity: 463/1269 - (36%)
• Similarity: 570/1269 - (44%)
• Gaps: 529/1269 - (41%)

  Fly     9 KWDKLSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDG-------DIDFDGFRRFLD 66
            ||..|||.||.|||:.|.|||:||:|||.||......:  |..|:|       .|||:||:.|:.
Mouse     6 KWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLA--KYNPEGKQDILNQTIDFEGFKLFMK 68

  Fly    67 AFLDCEAPLDLAKHLFVSFLKPNVTQAQLHGRALNQMAAISSTAACAPVTSHTKGSIPNINSIAE 131
            .||:.|.|.|...|||:||                              ::....|.||:.|...
Mouse    69 TFLEAELPDDFTAHLFMSF------------------------------SNKFPHSSPNVKSKPA 103

  Fly   132 LMPQCSGGGGGIGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPSKTGSVHPMLT 196
            |:            :||:...:|
Mouse   104 LL------------SGGLRMNKG------------------------------------------ 114

  Fly   197 VTPSPLASGPSMFQASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDAVSRILPAIGR 261
                          |..|.|    |||:::.:                            |.:
Mouse   115 --------------AITPPR----SSPANTCS----------------------------PEV-- 131

  Fly   262 HCPGSLESGSAQAEKRADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLEFMFRLYD 326
                                               :.|||:||||||||.|||||||||||||||
Mouse   132 -----------------------------------IHLKDIVCYLSLLERGRPEDKLEFMFRLYD 161

  Fly   327 TDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMTTI 391
            ||.||.||::|::.|:.|||.|||||.|||:||.|||.|||.|||||.||||||:||.:||||||
Mouse   162 TDGNGFLDSSELENIIGQMMHVAEYLEWDVTELNPILHEMMEEIDYDRDGTVSLEEWIQGGMTTI 226

  Fly   392 PLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAP 456
            |||||||::: .:|:||.||||||||:||||||||||||:|:||:||||..||||||||||..||
Mouse   227 PLLVLLGLEN-NVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAP 290

  Fly   457 ASCITTYVKSKKPKCGGDLLHH-WVEGNCYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASS 520
            .|||.|||||||   ..|::|| ||||||..:|.||.|.:|.|.|:|||.|.||...|||:|||.
Mouse   291 PSCIKTYVKSKK---NTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQTTLHNKCASH 352

  Fly   521 VKKECTLGEYSELIVPPTAICPAVL------------DRQ-------RSVNQAHKATH------- 559
            :|.||..|...:.|:|||.|||.||            :||       .|..|.:|||.
Mouse   353 LKPECDCGPLKDHILPPTTICPVVLQTMPSAGASVPEERQSTAKKEKSSSQQPNKATDKNKMQRA 417

  Fly   560 ---------FQITP-PDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLT 614
                     .|||| |.  :.||||||||||||:||:||.|||||:|||||||.||..||..||.
Mouse   418 NSVTMDGQGLQITPVPG--THPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLH 480

  Fly   615 LFKDLPRFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPK 679
            .|:|:|.|||:.|||||||||:|:.::...:...|.:.::||||||||||||||||||||||:.|
Mouse   481 FFRDVPDFRVLACGGDGTVGWILDCIEKANVVKHPPVAILPLGTGNDLARCLRWGGGYEGENLMK 545

  Fly   680 LMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQ 744
            ::.....::.:|||||..||  ||:..|
Mouse   546 ILKDIESSTEIMLDRWKFEV--TPNDKD------------------------------------- 571

  Fly   745 SKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTL 809
                                                                             
Mouse   572 ----------------------------------------------------------------- 571

  Fly   810 RTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQM 874
                                                  ||..|
Mouse   572 --------------------------------------EKGDP---------------------- 576

  Fly   875 QQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGG 939
                                                                             
Mouse   577 ----------------------------------------------------------------- 576

  Fly   940 GAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNII 1004
                                                                       |||:||
Mouse   577 -----------------------------------------------------------VPYSII 582

  Fly  1005 NNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVA 1069
            |||||:||||:|..:||:.|||:|.|||||||||.||||:.|||||:|:||.||||:||.||||.
Mouse   583 NNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQ 647

  Fly  1070 LDLANGPHLQGVALLNIPYTHGGSNLWGE---HLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFN 1131
            :||.| ..|:|:|:||||..|||||||||   ..|.:||.|           :..||..:.|  :
Mouse   648 IDLIN-ISLEGIAILNIPSMHGGSNLWGESKKKRSHRRIEK-----------KGSDKRPTLT--D 698

  Fly  1132 SVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWM 1196
            :.:|..|.||..|:|:||:|||..:.|||:.|||:::||||||||.|:|:|.|:.||||||||||
Mouse   699 AKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWM 763

  Fly  1197 QMPCTIKVTHKNQVPMLMAPRSEKGRGFFNLLCS 1230
            |.|||||:|||||.||||.|..:.|     |.||
Mouse   764 QTPCTIKITHKNQAPMLMGPPPKTG-----LFCS 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196	40/114 (35%)
		EFh	317..386	CDD:238008	50/68 (74%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	50/64 (78%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	30/51 (59%)
		DAGKc	573..694	CDD:214487	74/120 (62%)
		DAGKa	1003..1194	CDD:214486	110/193 (57%)
Dgkb	XP_006515130.1	DAG_kinase_N	6..148	CDD:464196	66/310 (21%)
		EFh	152..221	CDD:238008	50/68 (74%)
		C1_DGKbeta_rpt1	237..302	CDD:410395	50/64 (78%)
		C1_DGKbeta_rpt2	307..365	CDD:410441	31/57 (54%)
		DAGKc	439..560	CDD:214487	74/120 (62%)
		DAGKa	581..761	CDD:214486	110/193 (57%)