DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dgk and Prkcg

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	NP_035232.1	Gene:	Prkcg / 18752	MGIID:	97597	Length:	697	Species:	Mus musculus

Alignment Length:	312	Identity:	69/312 - (22%)
Similarity:	114/312 - (36%)	Gaps:	82/312 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 HVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITTYVKSKKPKCGGD 474
            |.:..:.|.:|.:|:.|.:.:.|:||:||.|.:|.:.||.||.:.....|...   .|.|:....
Mouse    36 HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGA---GKGPQTDDP 97

  Fly   475 LLHHWVEGNCYGR---CSKCRKRIKAYHGIT--GLTCRWCHMMLHNRCASSVKKECTL------G 528
            ...|....:.|..   |..|...:   :|:.  |:.|..|.|.:|.||..||...|.:      |
Mouse    98 RNKHKFRLHSYSSPTFCDHCGSLL---YGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRG 159

  Fly   529 EYSELIVPPTAICPAVLDRQRSVNQAH----KATHFQITPPDELSCP---LLVFVNPKSGGRQGD 586
            .....|..||:            ::.|    :|.:.....|:.||.|   |.:..:|::..:|..
Mouse   160 RLQLEIRAPTS------------DEIHITVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKT 212

  Fly   587 RILRKFQYMLNP----RQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIELAS 647
            :.::.   .|||    ..|::|..|..:..|:                      :|..|....:.
Mouse   213 KTVKA---TLNPVWNETFVFNLKPGDVERRLS----------------------VEVWDWDRTSR 252

  Fly   648 QPAIGVIPLGTGNDLARCLRWGGGY------EGE--NIP-------KLMDKF 684
            ...:|.:..|....|...:  .|.|      |||  |:|       .|:.||
Mouse   253 NDFMGAMSFGVSELLKAPV--DGWYKLLNQEEGEYYNVPVADADNCSLLQKF 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199
		EFh	317..386	CDD:238008
		EF-hand_7	318..382	CDD:290234
		C1	410..459	CDD:237996	16/48 (33%)
		C1_1	477..528	CDD:278556	15/61 (25%)
		DAGKc	573..694	CDD:214487	24/131 (18%)
		DAGKa	1003..1194	CDD:214486
Prkcg	NP_035232.1	C1_cPKC_rpt1	34..91	CDD:410383	17/57 (30%)
		C1_cPKC_rpt2	101..154	CDD:410386	15/55 (27%)
		C2_PKC_alpha_gamma	158..289	CDD:175992	31/169 (18%)
		STKc_cPKC	354..677	CDD:270739
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0696
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900