Protein Alignment Dgk and dgk-3

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: NP_499031.3
• Gene: dgk-3 / 186262
• WormBaseID: WBGene00000960
• Length: 795
• Species: Caenorhabditis elegans
• Alignment Length: 1222
• Identity: 402/1222 - (32%)
• Similarity: 533/1222 - (43%)
• Gaps: 459/1222 - (37%)

  Fly    13 LSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDGDIDFDGFRRFLDAFLDCEAPLDL 77
            |||.:|.:|.|.|:||.|||:|:|.:|.......:...:....|:.||||.||..:...:.|.||
 Worm     3 LSPEQFSRLSEYAAYSRRKLKDMLSDFQQDGKFYSYLSVDGQTINIDGFRAFLIDYFGADLPSDL 67

  Fly    78 AKHLFVSFLKPNVTQAQLHGRALNQMAAISSTAACAPVTSHTKGSIPNINSIAELMPQCSGGGGG 142
            ...||:||.||.:.:.:                     ||..:.:|..:.  |:.....||...|
 Worm    68 VDQLFLSFSKPPIKERR---------------------TSLFEDAISTVR--AKFSESLSGRMAG 109

  Fly   143 IGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPSKTGSVHPMLTVTPSPLASGPS 207
            :    .:||..|....||.                    |.:|.       .|...|.....||.
 Worm   110 L----NIAGGSGQQTDRSQ--------------------SSEPQ-------ALVCIPEDDVMGPR 143

  Fly   208 MFQASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDAVSRILPAIGRHCPGSLESGSA 272
            :                  |.|.||..|
 Worm   144 V------------------ANNDSQEPR------------------------------------- 153

  Fly   273 QAEKRADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLEFMFRLYDTDSNGVLDTAE 337
                                    :|||.::|.||||||..||:||:.:|.:||:|.||.||.:|
 Worm   154 ------------------------IPLKPLICTLSLLEADTPENKLDVVFHVYDSDGNGFLDKSE 194

  Fly   338 MDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMTTIPLLVLLGVDST 402
            :|.|:.|||.||.|..||..||..::::|||:||||.||.||.|||:|||:|.||||||||.| |
 Worm   195 IDGIIEQMMNVARYQQWDTIELEQVIRQMMVDIDYDNDGIVSFDEWRRGGLTNIPLLVLLGFD-T 258

  Fly   403 TLKEDGIHVWRLKHFSKPAYCNLCLNMLVGL-GKKGLCCVLCKYTVHERCVQHAPASCITTYVKS 466
            .:||||.|||||:||:||.|||.|.::|||. ||:||.|.|||||||||||:.|..:||.||...
 Worm   259 EMKEDGSHVWRLRHFTKPTYCNACCSILVGWGGKQGLSCSLCKYTVHERCVRSAATNCIRTYSSR 323

  Fly   467 KKPKCGGDLLHHWVEGNCYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSVKKECTLGEYS 531
            ::.|    |.|||.:.|...:|.||:..:..:.   |..|||||..:|:||.|::.:||.||...
 Worm   324 QQDK----LYHHWQDANATAKCVKCKATVGVFQ---GKGCRWCHNYVHHRCMSALAQECDLGALV 381

  Fly   532 ELIVPPTAICPAVLDRQRSVN------QAHKATHFQITPPDELSCPLLVFVNPKSGGRQGDRILR 590
            ..|:|||.|.||.|:|:.|.:      .:|.|:..|...|.....||||.|||||||:||.:||:
 Worm   382 HHILPPTHIFPAFLERKTSTSLKNHNFSSHSASLLQAVSPSNDCRPLLVLVNPKSGGKQGVKILQ 446

  Fly   591 KFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIELA-SQPAIGVI 654
            ||:|:|||||||||||.||:.||.||..|....::.||||||:|||||:||.:... .:|.:.|:
 Worm   447 KFEYLLNPRQVYDLSKTGPEPGLQLFSTLKNCNILVCGGDGTIGWVLESMDKMTFPHGRPPVAVL 511

  Fly   655 PLGTGNDLARCLRWGGGYEGENIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQ 719
            |||||||||||||||||||.||:.|::::..::|.:.:|||.|::
 Worm   512 PLGTGNDLARCLRWGGGYENENLHKILEQIEKSSLIDMDRWQIKI-------------------- 556

  Fly   720 KVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTT 784
                                                                             
 Worm   557 ----------------------------------------------------------------- 556

  Fly   785 TTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREK 849
                                                                        ::.|.
 Worm   557 ------------------------------------------------------------EITEN 561

  Fly   850 SVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQN 914
            ...||:
 Worm   562 KSARRA----------------------------------------------------------- 567

  Fly   915 NILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQH 979
                                                                             
 Worm   568 ----------------------------------------------------------------- 567

  Fly   980 LQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEY 1044
                         |:|..|.||:|||||||:||||:|..:||:.|||.|.||||||:|||||||.
 Worm   568 -------------SEKGDTPPYSIINNYFSIGVDASIAHRFHVMREKFPEKFNSRMRNKLWYFEL 619

  Fly  1045 ATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSA 1109
            .||||.::|||||||.|:|:|||.::||.....|:|:||||||..:|||||||      |.|||.
 Worm   620 GTSETLSSSCKNLHEQIDILCDGESIDLGQDASLEGIALLNIPSIYGGSNLWG------RSRKSK 678

  Fly  1110 G------PFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRAS 1168
            |      |...::|::               |...:||.||.|||::|||:.:.|||::.|:|.:
 Worm   679 GRMPGLFPMKNAEKMQ---------------LQTRVQDIGDGLIELVGLESAMQMGQIKAGVRGA 728

  Fly  1169 GRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSEK 1220
             |||:|||.|:|:|.|:||||||||||||.||.|::|||||..||:|....|
 Worm   729 -RRLSQCSTVVIQTHKSFPMQIDGEPWMQPPCIIQITHKNQAKMLVAAAPRK 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196	31/103 (30%)
		EFh	317..386	CDD:238008	37/68 (54%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	41/65 (63%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	19/50 (38%)
		DAGKc	573..694	CDD:214487	72/121 (60%)
		DAGKa	1003..1194	CDD:214486	104/196 (53%)
dgk-3	NP_499031.3	DAG_kinase_N	2..170	CDD:464196	64/299 (21%)
		EFh	174..243	CDD:238008	37/68 (54%)
		C1_DGK_typeI_rpt1	261..323	CDD:410349	41/61 (67%)
		C1_DGK_typeI_like_rpt2	330..378	CDD:410401	19/50 (38%)
		DAGKc	429..551	CDD:214487	72/121 (60%)
		DAGKa	578..753	CDD:214486	104/196 (53%)