DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dgk and pkc-2

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	NP_001359883.1	Gene:	pkc-2 / 181166	WormBaseID:	WBGene00004033	Length:	753	Species:	Caenorhabditis elegans

Alignment Length:	438	Identity:	84/438 - (19%)
Similarity:	151/438 - (34%)	Gaps:	127/438 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 HVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASC--ITTYVKSKKPKCG 472
            |.:..:.|.:|.:|:.|.:.|.|:.|:|..|.:|...||:||.:....:|  ....|.:..|:
Worm   110 HKFIARFFKQPTFCSHCKDFLWGITKQGFQCQVCTLVVHKRCHEFVNFACPGADKGVDTDDPR-- 172

  Fly   473 GDLLHHWVEGNCYGR---CSKCRKRIKAYHGI--TGLTCRWCHMMLHNRCASSVKKECTLGEYSE 532
              ..|.| :...|..   |..|...:   :||  .|:.|:.|...:|:||..:|...|......:
Worm   173 --QQHKW-KVQTYSSPTFCDHCGSLL---YGILHQGMKCQSCDTNVHHRCVKNVPNMCGTDNTEK 231

  Fly   533 LIVPPTAICPAVLDRQRSVNQAH-----------KATHFQITPPDELS-----CPLLVFVNPKSG 581
                          |.|...:||           :|.:.....|:.||     |.|:    |:..
Worm   232 --------------RGRLRIEAHIENDQLTIKILEAKNLIPMDPNGLSDPYVKCKLI----PEDS 278

  Fly   582 GRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIELA 646
            |.:..:..:..:..|||:.         .|..| :|.||        ||......:|..|....:
Worm   279 GCKSKQKTKTLRATLNPQW---------NETFT-YKLLP--------GDKDRRLSIEVWDWDRTS 325

  Fly   647 SQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDK-----FRRASTVMLDRWSIEVTNTPHSD 706
            ....:|.:..|                   |.:||.:     ::..|....:.::|.:  ||..|
Worm   326 RNDFMGSLSFG-------------------ISELMKEAASGWYKLLSAEEGEFYNINI--TPEYD 369

  Fly   707 DMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQV-------ATSMGTAASSTSIMMA 764
            :         :|:|         |.|.:.|.|......|.:.       |:::...:|:.:::.|
Worm   370 E---------DMEK---------VRKKMNENFITRDNSSSKPKDPAAPRASTLPLGSSNHNVIKA 416

  Fly   765 SKTETEMETMATMEFGSSTTTTNRTT--------TTKSISMSTFETQC 804
            |.... :..:....||.......:||        ..|.:.:...:.:|
Worm   417 SDFNF-LTVLGKGSFGKVLLGEQKTTKELFAIKVLKKDVIIQDDDVEC 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199
		EFh	317..386	CDD:238008
		EF-hand_7	318..382	CDD:290234
		C1	410..459	CDD:237996	15/48 (31%)
		C1_1	477..528	CDD:278556	15/55 (27%)
		DAGKc	573..694	CDD:214487	20/125 (16%)
		DAGKa	1003..1194	CDD:214486
pkc-2	NP_001359883.1	C1_1	110..160	CDD:365894	15/49 (31%)
		C1_1	175..225	CDD:365894	14/53 (26%)
		C2_PKC_alpha_gamma	232..362	CDD:175992	30/170 (18%)
		STKc_cPKC	422..744	CDD:270739	6/42 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910