DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgk and dgk-2

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	NP_001024679.1	Gene:	dgk-2 / 180720	WormBaseID:	WBGene00000959	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	850	Identity:	166/850 - (19%)
Similarity:	265/850 - (31%)	Gaps:	375/850 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   399 VDSTTLKEDGIHVWRLKHFSKP-AYCNLCLNMLVGLGKKGLCCVLCKYTVHE-RCVQHAPASCIT 461
            ::.|:.|..  |.|...::|:. .||:.|...:|    .|..|..|...|.. .|::     .::
Worm    38 INDTSSKSG--HYWSSINYSEQHNYCSGCKEHIV----SGYECDNCLLKVDNINCLR-----AVS 91

  Fly   462 TYVKSK-KP-KCGGDLL-HHWVEGNCYGR--CSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSV 521
            |.::.| .| .|..:.. |||:.||....  |..|.:..... |:....|.||..::|.:|....
Worm    92 TKIQCKVNPIHCRKETFDHHWICGNIGADLFCEVCEELCGGV-GLQDFRCSWCWRVVHTKCKPKF 155

  Fly   522 KKECTLGEYSELIVPPTAICP----------AVLDRQRSVNQAHKATHFQITPPDELSCPLLVFV 576
            .|.|..|.....|:||..:..          ||:|:            .:|....|...|::|.|
Worm   156 TKHCDFGGLKRTIIPPYCVTTRRPGNRNQRMAVIDK------------IEIPVDIEKWRPIMVIV 208

  Fly   577 NPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPR--FRVICCGGDGTVGWVLEA 639
            |||||...|.::||.|:..|:|.||.|:.|......|....:.|.  .|::..|||||:...|:.
Worm   209 NPKSGSGAGKQLLRNFRAHLHPAQVVDVLKSNIAASLRWIDEHPNVDVRILIAGGDGTICSALDQ 273

  Fly   640 MDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGE-NIPKLMDKFRRASTVMLDRWSIEVTNTP 703
            :|:  |:.:..:.|:||||||||:|.|:||...:|: ::.|||:..:.|...::|||:|
Worm   274 IDT--LSRRIPVAVLPLGTGNDLSRLLKWGKKCDGDIDVIKLMEDIQEAEVTLVDRWTI------ 330

  Fly   704 HSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTE 768

Worm   331 ----------------------------------------------------------------- 330

  Fly   769 TEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAE 833
                                                                          |||
Worm   331 --------------------------------------------------------------DAE 333

  Fly   834 TEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATP 898
            :
Worm   334 S---------------------------------------------------------------- 334

  Fly   899 VGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPT 963

Worm   335 ----------------------------------------------------------------- 334

  Fly   964 TPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNP 1028
                                |::..:::||:|..:     :.||.||||||.:.:.....||..|
Worm   335 --------------------QKKLGVRLQSNKTLS-----MTNYVSVGVDACVTLGMQNTRESIP 374

  Fly  1029 HKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGS 1093
            ...:||:.||..:|.:.|.:.|...||.|:|.|::..|.|.::|   |.::|:..|||||...|.
Worm   375 RAMSSRLLNKFLFFTFGTKDVFERVCKGLNERIDLYLDDVHVNL---PDIEGLIFLNIPYWGAGV 436

  Fly  1094 NLWGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHM 1158
            ..|..:....|                                   |:..|.:|||..:.:..|:
Worm   437 KPWATYNDSHR-----------------------------------QECDDEMIEVFAVTSSFHI 466

  Fly  1159 GQVRTGLRASGRRLAQC--SEVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPML-MAPRSEK 1220
            .|::.|| ||...:.|.  ::::.|...:||||.|||.|:....|:.::||.:..|| .|.:...
Worm   467 AQMQIGL-ASPLCIGQAKHAKLVFKGNHSFPMQSDGEAWVNSAGTVLISHKCKTAMLRKAEKQTT 530

  Fly  1221 GRGFF 1225
            |.|.|
Worm   531 GCGMF 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199
		EFh	317..386	CDD:238008
		EF-hand_7	318..382	CDD:290234
		C1	410..459	CDD:237996	12/50 (24%)
		C1_1	477..528	CDD:278556	15/52 (29%)
		DAGKc	573..694	CDD:214487	46/123 (37%)
		DAGKa	1003..1194	CDD:214486	55/192 (29%)
dgk-2	NP_001024679.1	C1	110..159	CDD:237996	14/49 (29%)
		DAGK_cat	203..325	CDD:279163	47/123 (38%)
		DAGK_acc	350..503	CDD:295305	55/191 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910