DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgk and dgk-1

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	NP_001379646.1	Gene:	dgk-1 / 180452	WormBaseID:	WBGene00000958	Length:	952	Species:	Caenorhabditis elegans

Alignment Length:	1189	Identity:	211/1189 - (17%)
Similarity:	318/1189 - (26%)	Gaps:	689/1189 - (57%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 HVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITTYVK-SKKP---- 469
            |.:..|.|.|||||:.|.:.:.|:...|..|.:|.:..||:|::...:.|.:..:: .|.|
Worm    21 HYFVKKTFGKPAYCHHCCDKIWGMLTTGYSCEMCNFVCHEKCLRTVVSYCSSVALQLIKNPVAHT 85

  Fly   470 ----------------KCGGDLL-----------------------------------------H 477
                            |...|.|                                         |
Worm    86 WSAPCLIKRKYCCVCRKRTDDALSVECEVCEYYVHVDCSDLAVSDCKEAATYVANMESANTVQYH 150

  Fly   478 HWVEGNC--YGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSVKKECTLGEYSELIVPPTAI 540
            |..|||.  ..:|..|||...:...:.|:.|.||....|..|...:.|||..|...::::||..:
Worm   151 HMREGNLPKESKCIVCRKTCFSTECLAGMRCEWCGQTAHAVCYRQMDKECDFGVLRKIMLPPMCL 215

  Fly   541 ---------------------------CPA----------------------------------- 543
                                       .|:
Worm   216 TIPRTELPMEQLLNISSHDQPQSRKVSSPSKIQADDVSTSGEDVKEREDFEIIRVFDGNNSYRSQ 280

  Fly   544 -----VLDRQRSVNQAHKAT----HFQITP----------------------------------- 564
                 |:.:..||.|...|.    |...||
Worm   281 ISRNIVVAKHVSVQQVRDAALRRFHINDTPERYYITQVVGEVEEEILEDPVPLRNVKRPEGKRAQ 345

  Fly   565 --------PD------------------------------------------------------- 566
                    ||
Worm   346 IFIRYYDDPDKDEVKVYGGWLRKVPVTFCAISVSKDTVVQDLVTDALYHFGLDGSCWNRYNLIEV 410

  Fly   567 -------ELSC------------------------------------------------------ 570
                   |.:|
Worm   411 SLDRGVAERTCNPQENVLQLVRNLRKDSLRRYHVVRFYVQEKEDPHDHAVFVGNLPVSLAQRQYE 475

  Fly   571 ----------------------------------------------------------------- 570

Worm   476 RILLKLLGAKEKPFTAIGPIYFEYGSLIITFNTPKAATAAVQKLQSAIYEEKKLIVLCLPNVQPQ 540

  Fly   571 -------PLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCG 628
                   ||||.||.||||.||..:::.|:.:|||.||:|:..|||..||.:|:::|:::::.||
Worm   541 MIPKDVEPLLVLVNVKSGGCQGTELIQSFRKLLNPFQVFDVLNGGPLVGLYVFRNIPKYKILACG 605

  Fly   629 GDGTVGWVLEAMDSIELASQ------PAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFR-- 685
            ||||:||||:.:|   :|.|      |..|::||||||||||.|||||||.||..|  ||..:
Worm   606 GDGTIGWVLQCLD---IAKQDAACFSPPCGIVPLGTGNDLARVLRWGGGYTGEENP--MDILKDV 665

  Fly   686 -RASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVA 749
             .|.||.||||::.                                       |.|.:|
Worm   666 IEADTVKLDRWAVV---------------------------------------FHEEER------ 685

  Fly   750 TSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMS 814

Worm   686 ----------------------------------------------------------------- 685

  Fly   815 SSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQ 879
              :..||||
Worm   686 --NQPTSSG-------------------------------------------------------- 692

  Fly   880 QQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDG 944
                                      |.::.|:|
Worm   693 --------------------------NQTEMNEQ------------------------------- 700

  Fly   945 TKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFS 1009
                            |...|...:|::                              |:||||.
Worm   701 ----------------TMNNPEDQTSMI------------------------------IMNNYFG 719

  Fly  1010 VGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSET-FAASCKNLHESIEIVCDGVALDLA 1073
            :|:||.:|:|||.:|:.||.||.||:.||..|.:....:. |..:||:|.:.||:..||..::|
Worm   720 IGIDADVCLKFHNKRDANPEKFQSRLFNKTQYAKIGLQKMFFERTCKDLWKRIELEVDGRIIEL- 783

  Fly  1074 NGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVA 1138
              |:::|:.:||:.....|:|.||       ..|..|.|.|            .|.:
Worm   784 --PNIEGIVVLNLLSWGSGANPWG-------TSKEEGNFSK------------PTHY-------- 819

  Fly  1139 IQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIK 1203
                 |.|:||:|:.:...:|.:::.| |:|.|:||...:.|.|.:.:|:|:||||.:|.|.||.
Worm   820 -----DGLLEVVGISDVSRLGLIQSKL-AAGIRIAQGGSIRITTHEEWPVQVDGEPHIQPPGTIT 878

  Fly  1204 VTHKNQVPMLMAPRSEKGR 1222
            :. |:.:...|..:::|.|
Worm   879 IL-KSALKAQMLKKAKKSR 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199
		EFh	317..386	CDD:238008
		EF-hand_7	318..382	CDD:290234
		C1	410..459	CDD:237996	16/48 (33%)
		C1_1	477..528	CDD:278556	18/52 (35%)
		DAGKc	573..694	CDD:214487	65/129 (50%)
		DAGKa	1003..1194	CDD:214486	62/191 (32%)
dgk-1	NP_001379646.1	C1_DGKtheta_typeV_rpt1	20..74	CDD:410353	17/52 (33%)
		C1_DGKtheta_typeV_rpt2	79..135	CDD:410354	5/55 (9%)
		C1_DGKtheta_typeV_rpt3	150..212	CDD:410404	19/61 (31%)
		RA1_DAGK-theta	266..353	CDD:340631	8/86 (9%)
		Ubiquitin_like_fold	359..452	CDD:421700	2/92 (2%)
		DAGKc	550..675	CDD:214487	65/129 (50%)
		DAGK_acc	713..869	CDD:395484	62/191 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910