Protein Alignment Dgk and dgk-4

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: NP_501476.2
• Gene: dgk-4 / 177667
• WormBaseID: WBGene00006483
• Length: 1339
• Species: Caenorhabditis elegans
• Alignment Length: 1021
• Identity: 263/1021 - (25%)
• Similarity: 413/1021 - (40%)
• Gaps: 271/1021 - (26%)

  Fly   392 PLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAP 456
            ||:.||  :.|:    |.|.|...:..:|.:||.|...|.|:...|..|.:||...|.:|..:..
 Worm    36 PLVALL--EGTS----GHHHWTETNHPRPTFCNYCREKLNGVPWHGYTCDICKVKAHRKCRDNLT 94

  Fly   457 ASC-------ITTYVKSKKPKCGGDLLHHWVEGN--CYGRCSKCRKRIKAYHGITGLTCRWCHMM 512
            ..|       |..:::...|: ...|.|.|:|||  ...:||.|.|...:...:....|.||...
 Worm    95 EQCKWTNQSSIPQHLQFISPE-NSILPHQWMEGNLPMPSKCSVCEKPCGSVRKLIDYRCIWCGCC 158

  Fly   513 LHNRCASSVKKECTLGEYSELIVPPTA---ICP---AVLDRQRSVNQAHKATHFQITPPDELSCP 571
            :|:.|..::.:.|:||..:..::.|.|   :.|   |||..:.....:...:            |
 Worm   159 VHDTCIGNLARACSLGHSALSVISPLAMKEVTPNGTAVLREEAYGGDSPGGS------------P 211

  Fly   572 LLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWV 636
            |:|.:|.|||..||.||::||:.:|||.||:|:...||...||.|..|..|||:.||||||||||
 Worm   212 LIVLINAKSGDSQGQRIIKKFRRILNPIQVFDIIATGPDFALTFFSHLESFRVLVCGGDGTVGWV 276

  Fly   637 LEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGG-YEGENIPKLMDKFRRASTVMLDRWSIEVT 700
            |.|.|.:.|.|:..:.::||||||||||.|.||.. |:...:|:::....||.|.||||||:...
 Worm   277 LSAFDRLNLHSKCQLAILPLGTGNDLARVLGWGHAFYDDTLLPQVVRTMERAHTKMLDRWSVLAI 341

  Fly   701 NTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMAS 765
            ..|.:|.:|....|      |||..::.:.    .|:..:|...:.|:.|::.....|.|...:.
 Worm   342 EGPQADAVRRYEEL------VIEKVRTFLE----AEQTWDIIHAANQLCTTIRDLVHSVSHTYSD 396

  Fly   766 KTETEMETMATMEFGSSTTTT-------------------------------------------- 786
            ....:::.......|.|.|.|
 Worm   397 LENNKLKLDDESRLGGSDTMTENCNTLLGKLDRLMKSLKEDANCLEESGFEPGDDDDCSTGDEML 461

  Fly   787 -------NRTTTTKS-----ISMSTF---------ETQCLQ---------QTLRTAMSSSSSNTS 821
                   ||..:.|.     |||:..         .|.|.:         :|..:.::.|.||.|
 Worm   462 KKRDSVVNRANSLKKAFREVISMAEKGIDQHYRDPNTACTKRERFRKKRSKTTPSVLTISHSNLS 526

  Fly   822 SGSPCN------GN---QDAETEV---------------DSHAAAAADVREKSVPRRSGETEKQS 862
            |.|.|:      |.   ||.:.|.               .|.:|....:......|...|.||.|
 Worm   527 SSSACSPPCSPAGEDPPQDDQKEFRSASCKATFEISHSQSSSSAVLTALFNAQSARTYDELEKPS 591

  Fly   863 LETL----------------------LLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSN-QS 904
            :.|:                      .:::::::.|:...::..|::  .|:....:|.... .|
 Worm   592 IGTVHPPTPGATREPSTAYDDDEENENVENRKEIDQKSNSKKSSVST--PEDITKGSPDRPRIYS 654

  Fly   905 DNSSQRNKQNNILKQQITLSL---------------DLSDHEDEPKDDGGGAGDGTKSNGNSI-P 953
            |.:..:|.:.  :|.|   ||               |.|.:.|....:|..:|.|..::|::: |
 Worm   655 DTTLNKNMEK--MKSQ---SLHPICSSADKMKQSHSDSSLYADYEHLEGSSSGCGAGASGSTLSP 714

  Fly   954 ATPATPIT----PTTPNAASSVLQQQQQQHLQ-----------------------------FEQQ 985
            |..:...|    ........|.|......||:                             ..::
 Worm   715 ARASDSATWSRIKERKRTVGSDLGLSSSSHLRSCRNMLSGFAGGSLIAEILLLNARVLSQMSSRR 779

  Fly   986 QKPIKVQSD---KDCTVPYN------IINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWY 1041
            .....:.:.   .||..|:.      ::||||.:|:||.|.::||.:||:: .|..||.|..:||
 Worm   780 NSAANIANQIPTSDCQTPFTQYKEMCVMNNYFGIGLDAKIALEFHNKREES-EKTRSRSKLFMWY 843

  Fly  1042 FEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIR 1106
            ......|....:.:||.:.|::.||||.:||   |.|||:.:||||...||:|.||        |
 Worm   844 GILGGKELMHRTYRNLEQRIKLECDGVPIDL---PSLQGIVILNIPSYSGGANFWG--------R 897

  Fly  1107 KSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHM--GQVRTGLRASG 1169
            ...||            ||:            :|.|.||::||:.|...:|:  .:|...:|...
 Worm   898 NKDGP------------EFT------------VQSFDDRILEVVALFGVIHVATSRVPNAVRLQN 938

  Fly  1170 RRLAQCSEV--IIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPML 1213
            .|:|||..|  :|...:..|:|:|||||:|.|..:::.|||:..||
 Worm   939 HRIAQCRHVRIVILGDEPIPVQVDGEPWLQPPGIMQIVHKNRAQML 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008
		C1_DGKbeta_rpt1	403..468	CDD:410395	17/71 (24%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	15/52 (29%)
		DAGKc	573..694	CDD:214487	61/121 (50%)
		DAGKa	1003..1194	CDD:214486	66/194 (34%)
dgk-4	NP_501476.2	C1_DGK_typeII_rpt1	44..103	CDD:410350	17/62 (27%)
		C1_DGK_typeII_rpt2	121..174	CDD:410402	15/52 (29%)
		DAGKc	213..335	CDD:214487	61/121 (50%)
		DAGKa	806..965	CDD:214486	66/194 (34%)
		SAM_DGK-delta-eta	1186..1250	CDD:188906