Protein Alignment Dgk and DGKH

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: NP_821077.1
• Gene: DGKH / 160851
• HGNCID: 2854
• Length: 1220
• Species: Homo sapiens
• Alignment Length: 1036
• Identity: 286/1036 - (27%)
• Similarity: 455/1036 - (43%)
• Gaps: 199/1036 - (19%)

  Fly   264 PGSLESGSAQAEKRADIKLLARKLSHFDPLTLKVPLKD--VVCYLSLLEAGRPEDKLEFMFR--- 323
            ||. :|..::||:....||: ||:|....:..|..:|:  ::...|..:..:   |..|..|
Human    34 PGE-DSSDSEAEQEGPQKLI-RKVSTSGQIRTKTSIKEGQLLKQTSSFQRWK---KRYFKLRGRT 93

  Fly   324 -LYDTDSNG-VLDTAEM-DAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQR 385
             .|..||.. :.|..:: ||.|.:  |..:......:.:.|..:.|:.     |:....:::|
Human    94 LYYAKDSKSLIFDEVDLSDASVAE--ASTKNANNSFTIITPFRRLMLC-----AENRKEMEDW-- 149

  Fly   386 GGMTTIPLLVLLGVDSTTLKE------------DGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGL 438
                      :..:.|...:|            .|:|.|.....::|.:||:|...|.|:...||
Human   150 ----------ISSLKSVQTREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGL 204

  Fly   439 CCVLCKYTVHERCVQHAPASCITTYVKSKKPKCGGDLL---------HHWVEGN--CYGRCSKCR 492
            .|.:||:..|:||...|..:|..|.:.|    .|.|::         |.|:|||  ...:|:.|.
Human   205 SCEVCKFKAHKRCAVRATNNCKWTTLAS----IGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCD 265

  Fly   493 KRIKAYHGITGLTCRWCHMMLHNRCASSVKKECTLGEYSELIVPPTAI--------CPAVLDRQR 549
            |...:...:....|.||..|:|..|.......|.||:....|:||.|:        |.|...
Human   266 KTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQCKVSIIPPIALNSTDSDGFCRATFS--- 327

  Fly   550 SVNQAHKATHFQITPPDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLT 614
                      |.::       |||||||.|||..||.:.||:|:.:|||.||:||..|||..||.
Human   328 ----------FCVS-------PLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLR 375

  Fly   615 LFKDLPRFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGE-NIP 678
            ||:....||::.|||||:|||||..:|.:.|..|..:||:||||||||||.|.|||.|:.: .:|
Human   376 LFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLP 440

  Fly   679 KLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQR 743
            ::::|..||||.|||||||    ..:...:.||.:|.....:..|.....:.:.|:.....:|..
Human   441 QILEKLERASTKMLDRWSI----MTYELKLPPKASLLPGPPEASEEFYMTIYEDSVATHLTKILN 501

  Fly   744 QSKQVATSMGTAASSTSIMMASKT--ETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQ 806
            ..:...           ::.::||  ||..:.:|.:|.....|..|........|..:...:.|:
Human   502 SDEHAV-----------VISSAKTLCETVKDFVAKVEKTYDKTLENAVVADAVASKCSVLNEKLE 555

  Fly   807 QTLRTA-MSSSSSNTSSG-SPCNGNQDA-ETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLL 868
            |.|:.. ..|.::....| ||....:|| |:..:.....:.:.....|.:.|.:...:..|.:|.
Human   556 QLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLGDDVTKPSSQKAVKPREIMLR 620

  Fly   869 QHKQQMQQQQQQQQQG-----VTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLS 928
            .:..:...:|..::.|     .|....|.|..::...|.::|.|.:..|.:. .|:.||:
Human   621 ANSLKKAVRQVIEEAGKVMDDPTVHPCEPANQSSDYDSTETDESKEEAKDDG-AKESITV----- 679

  Fly   929 DHEDEPKDDGGGAGDGTKSNGNSIPATPAT-------PITPT---TPN---------AASSVLQQ 974
              :..|:.....|..| .|..:|:|. ||.       |:..|   .|.         |.||::.:
Human   680 --KTAPRSPDARASYG-HSQTDSVPG-PAVAASKENLPVLNTRIICPGLRAGLAASIAGSSIINK 740

  Fly   975 QQQQHLQFEQQQKPIK----VQSDKDCTVPYN---IINNYFSVGVDAAICVKFHLEREKNPHKFN 1032
            ....::.      |..    :..|.|....|:   ::||||.:|:||.|.::|:.:||::|.|..
Human   741 MLLANID------PFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLDAKISLEFNNKREEHPEKCR 799

  Fly  1033 SRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWG 1097
            ||.||.:||....|.|....|.|||.:.:::.|||..:.|   |.|||:|:||||...||:|.||
Human   800 SRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPL---PSLQGIAVLNIPSYAGGTNFWG 861

  Fly  1098 EHLSQKRIRKSAGPFGKSKKLRAGDKE---FSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMG 1159
                                   |.||   |:|.||:            |:::||:.:.:.:.|.
Human   862 -----------------------GTKEDDIFAAPSFD------------DKILEVVAIFDSMQMA 891

  Fly  1160 QVRTGLRASGRRLAQCS--EVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRS 1218
            ..|. ::....|:|||.  ::.|...:..|:|:|||.|:|.|..||:.|||:..||...|:
Human   892 VSRV-IKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRA 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008	15/74 (20%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	22/76 (29%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	15/52 (29%)
		DAGKc	573..694	CDD:214487	67/121 (55%)
		DAGKa	1003..1194	CDD:214486	64/195 (33%)
DGKH	NP_821077.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..60		10/27 (37%)
		PH_DGK_type2	67..163	CDD:270093	19/117 (16%)
		C1_DGKeta_rpt1	147..232	CDD:410398	23/96 (24%)
		C1_DGKeta_rpt2	243..304	CDD:410444	17/60 (28%)
		DAGKc	334..456	CDD:214487	67/121 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	581..617		5/35 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	636..705		18/78 (23%)
		DAGKa	770..927	CDD:214486	64/195 (33%)
		SAM_DGK-eta	1147..1211	CDD:188975
		PDZ-binding	1218..1220