Protein Alignment Dgk and DGKG

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: NP_001337.2
• Gene: DGKG / 1608
• HGNCID: 2853
• Length: 791
• Species: Homo sapiens
• Alignment Length: 1237
• Identity: 415/1237 - (33%)
• Similarity: 540/1237 - (43%)
• Gaps: 476/1237 - (38%)

  Fly     9 KWDKLSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDGDIDFDGFRRFLDAFLDCEA 73
            :|..|:|.||.|||:.:.||::|::|.|.||:  ...|..:..|...|.:|.|:.|:.|:|:.:.
Human     5 RWVSLTPEEFDQLQKYSEYSSKKIKDALTEFN--EGGSLKQYDPHEPISYDVFKLFMRAYLEVDL 67

  Fly    74 PLDLAKHLFVSFLKPNVTQAQLHGRALNQMAAISSTAACAPVTSHTKGSIPNINSIAELMPQCSG 138
            |..|:.|||::|
Human    68 PQPLSTHLFLAF----------------------------------------------------- 79

  Fly   139 GGGGIGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPSKTGSVHPMLTVTPSPLA 203
                                                       |..|....|.||         .
Human    80 -------------------------------------------SQKPRHETSDHP---------T 92

  Fly   204 SGPSMFQASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDAVSRILPAIGRHCPGSLE 268
            .|     |||        |.::||..:.|.:.|::|..                   ..|....|
Human    93 EG-----ASN--------SEANSADTNIQNADNATKAD-------------------EACAPDTE 125

  Fly   269 SGSAQAEKRADIKLLARKLSHFDPLTLKVP-----------LKDVVCYLSLLEAGRPEDKLEFMF 322
            |..|:.:..|:.::.|      .||...||           ||||||||||||.|||:|||||||
Human   126 SNMAEKQAPAEDQVAA------TPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKLEFMF 184

  Fly   323 RLYDTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGG 387
            ||||:|.||:||.||||.|||||:.:|:||.||.:||||||:||:..:|||.||.|||.||..||
Human   185 RLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFVSLQEWVHGG 249

  Fly   388 MTTIPLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCV 452
            |||||||||||:|.:..|.||.|.|.:|||.||.|||.|..||:|:.|:||||..||||||||||
Human   250 MTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCV 314

  Fly   453 QHAPASCITTYVKSKKPKCGGDLLHH-WVEGNCYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNR 516
            ......|:.||.|:|:   .|:::.| |||||...:|.:|.|.||.|..:|...|.||.|..|.:
Human   315 SRNIPGCVKTYSKAKR---SGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRK 376

  Fly   517 CASSVKKECTLGEYSELIVPPTAICPAVLDRQRSVN------QAHKATHFQITPPDELSCPLLVF 575
            |..|..  |..||..:.|:.||:|||...||....:      :......::|.|... :.||||.
Human   377 CELSTL--CDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPG-THPLLVL 438

  Fly   576 VNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAM 640
            ||||||||||:||||||.|:|||:||::|..|||..||..|:|.|.|||:.|||||||||:|:.:
Human   439 VNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCI 503

  Fly   641 DSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRASTVMLDRWSIEVTNTPHS 705
            |....|..|.:.|:||||||||||||||||||||.::.|::....::..||||||.:||.
Human   504 DKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVI----- 563

  Fly   706 DDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETE 770
                |:                           ||::
Human   564 ----PR---------------------------EEVE---------------------------- 569

  Fly   771 METMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETE 835
                                                                    ||:|
Human   570 --------------------------------------------------------NGDQ----- 573

  Fly   836 VDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVG 900
                                                                             
Human   574 ----------------------------------------------------------------- 573

  Fly   901 SNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTP 965
                                                                             
Human   574 ----------------------------------------------------------------- 573

  Fly   966 NAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHK 1030
                                             |||:|:|||||:||||:|..:||:.|||:|.|
Human   574 ---------------------------------VPYSIMNNYFSIGVDASIAHRFHVMREKHPEK 605

  Fly  1031 FNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNL 1095
            |||||||||||||:.|||||||:||.||:.||:.||||.:||:| ..|:|:|:||||..:||:||
Human   606 FNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSN-IFLEGIAILNIPSMYGGTNL 669

  Fly  1096 WGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQ 1160
            |||                :||.||..:|......:..:|...:||..|:|:||:|||..:.|||
Human   670 WGE----------------NKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQ 718

  Fly  1161 VRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSEKGRGFF 1225
            :.|||:::|||||||:.|.|:|.|..|||:|||||||..||||:|||||.||:|.|..:.  .||
Human   719 IYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKS--SFF 781

  Fly  1226 NL 1227
            :|
Human   782 SL 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196	29/107 (27%)
		EFh	317..386	CDD:238008	47/68 (69%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	36/64 (56%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	21/51 (41%)
		DAGKc	573..694	CDD:214487	74/120 (62%)
		DAGKa	1003..1194	CDD:214486	102/190 (54%)
DGKG	NP_001337.2	DAG_kinase_N	5..175	CDD:464196	66/314 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..103		9/42 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..154		10/61 (16%)
		EFh	179..248	CDD:238008	47/68 (69%)
		C1	255..328	CDD:412127	42/72 (58%)
		C1_DGKgamma_rpt2	337..395	CDD:410442	24/59 (41%)
		DAGKc	436..557	CDD:214487	74/120 (62%)
		DAGKa	578..752	CDD:214486	102/190 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..791		7/18 (39%)