DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgk and DGKG

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	NP_001337.2	Gene:	DGKG / 1608	HGNCID:	2853	Length:	791	Species:	Homo sapiens

Alignment Length:	1237	Identity:	415/1237 - (33%)
Similarity:	540/1237 - (43%)	Gaps:	476/1237 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KWDKLSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDGDIDFDGFRRFLDAFLDCEA 73
            :|..|:|.||.|||:.:.||::|::|.|.||:  ...|..:..|...|.:|.|:.|:.|:|:.:.
Human     5 RWVSLTPEEFDQLQKYSEYSSKKIKDALTEFN--EGGSLKQYDPHEPISYDVFKLFMRAYLEVDL 67

  Fly    74 PLDLAKHLFVSFLKPNVTQAQLHGRALNQMAAISSTAACAPVTSHTKGSIPNINSIAELMPQCSG 138
            |..|:.|||::|
Human    68 PQPLSTHLFLAF----------------------------------------------------- 79

  Fly   139 GGGGIGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPSKTGSVHPMLTVTPSPLA 203
                                                       |..|....|.||         .
Human    80 -------------------------------------------SQKPRHETSDHP---------T 92

  Fly   204 SGPSMFQASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDAVSRILPAIGRHCPGSLE 268
            .|     |||        |.::||..:.|.:.|::|..                   ..|....|
Human    93 EG-----ASN--------SEANSADTNIQNADNATKAD-------------------EACAPDTE 125

  Fly   269 SGSAQAEKRADIKLLARKLSHFDPLTLKVP-----------LKDVVCYLSLLEAGRPEDKLEFMF 322
            |..|:.:..|:.::.|      .||...||           ||||||||||||.|||:|||||||
Human   126 SNMAEKQAPAEDQVAA------TPLEPPVPRSSSSESPVVYLKDVVCYLSLLETGRPQDKLEFMF 184

  Fly   323 RLYDTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGG 387
            ||||:|.||:||.||||.|||||:.:|:||.||.:||||||:||:..:|||.||.|||.||..||
Human   185 RLYDSDENGLLDQAEMDCIVNQMLHIAQYLEWDPTELRPILKEMLQGMDYDRDGFVSLQEWVHGG 249

  Fly   388 MTTIPLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCV 452
            |||||||||||:|.:..|.||.|.|.:|||.||.|||.|..||:|:.|:||||..||||||||||
Human   250 MTTIPLLVLLGMDDSGSKGDGRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCV 314

  Fly   453 QHAPASCITTYVKSKKPKCGGDLLHH-WVEGNCYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNR 516
            ......|:.||.|:|:   .|:::.| |||||...:|.:|.|.||.|..:|...|.||.|..|.:
Human   315 SRNIPGCVKTYSKAKR---SGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRK 376

  Fly   517 CASSVKKECTLGEYSELIVPPTAICPAVLDRQRSVN------QAHKATHFQITPPDELSCPLLVF 575
            |..|..  |..||..:.|:.||:|||...||....:      :......::|.|... :.||||.
Human   377 CELSTL--CDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPG-THPLLVL 438

  Fly   576 VNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAM 640
            ||||||||||:||||||.|:|||:||::|..|||..||..|:|.|.|||:.|||||||||:|:.:
Human   439 VNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCI 503

  Fly   641 DSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRASTVMLDRWSIEVTNTPHS 705
            |....|..|.:.|:||||||||||||||||||||.::.|::....::..||||||.:||.
Human   504 DKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEVI----- 563

  Fly   706 DDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETE 770
                |:                           ||::
Human   564 ----PR---------------------------EEVE---------------------------- 569

  Fly   771 METMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETE 835
                                                                    ||:|
Human   570 --------------------------------------------------------NGDQ----- 573

  Fly   836 VDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVG 900

Human   574 ----------------------------------------------------------------- 573

  Fly   901 SNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTP 965

Human   574 ----------------------------------------------------------------- 573

  Fly   966 NAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHK 1030
                                             |||:|:|||||:||||:|..:||:.|||:|.|
Human   574 ---------------------------------VPYSIMNNYFSIGVDASIAHRFHVMREKHPEK 605

  Fly  1031 FNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNL 1095
            |||||||||||||:.|||||||:||.||:.||:.||||.:||:| ..|:|:|:||||..:||:||
Human   606 FNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGVDLSN-IFLEGIAILNIPSMYGGTNL 669

  Fly  1096 WGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQ 1160
            |||                :||.||..:|......:..:|...:||..|:|:||:|||..:.|||
Human   670 WGE----------------NKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQ 718

  Fly  1161 VRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSEKGRGFF 1225
            :.|||:::|||||||:.|.|:|.|..|||:|||||||..||||:|||||.||:|.|..:.  .||
Human   719 IYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKS--SFF 781

  Fly  1226 NL 1227
            :|
Human   782 SL 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199	66/314 (21%)
		EFh	317..386	CDD:238008	47/68 (69%)
		EF-hand_7	318..382	CDD:290234	44/63 (70%)
		C1	410..459	CDD:237996	29/48 (60%)
		C1_1	477..528	CDD:278556	21/51 (41%)
		DAGKc	573..694	CDD:214487	74/120 (62%)
		DAGKa	1003..1194	CDD:214486	102/190 (54%)
DGKG	NP_001337.2	DAG_kinase_N	5..175	CDD:291199	66/314 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..103		9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..154		10/61 (16%)
		EFh	179..248	CDD:238008	47/68 (69%)
		EF-hand_7	180..244	CDD:290234	44/63 (70%)
		C1	272..321	CDD:237996	29/48 (60%)
		C1	336..377	CDD:197519	18/40 (45%)
		DAGKc	436..557	CDD:214487	74/120 (62%)
		DAGKa	578..752	CDD:214486	102/190 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..791		7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2616
eggNOG	1	0.900	-	-		E1_KOG1169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	621	1.000	Inparanoid score	I881
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47969
OrthoDB	1	1.010	-	-		D633642at2759
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	1	1.000	-	-		otm41616
orthoMCL	1	0.900	-	-		OOG6_102301
Panther	1	1.100	-	-	LDO	PTHR11255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X838
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840