DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dgk and DGKB

DIOPT Version :9

Sequence 1:NP_724619.2 Gene:Dgk / 35738 FlyBaseID:FBgn0085390 Length:1230 Species:Drosophila melanogaster
Sequence 2:NP_001337634.1 Gene:DGKB / 1607 HGNCID:2850 Length:804 Species:Homo sapiens


Alignment Length:1270 Identity:459/1270 - (36%)
Similarity:571/1270 - (44%) Gaps:530/1270 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 KWDKLSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDG-------DIDFDGFRRFLD 66
            ||..|||.||.|||:.|.|||:||:|||.||......:  |..|:|       .|||:||:.|:.
Human     6 KWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLA--KYNPEGKQDILNQTIDFEGFKLFMK 68

  Fly    67 AFLDCEAPLDLAKHLFVSFLKPNVTQAQLHGRALNQMAAISSTAACAPVTSHTKGSIPNINSIAE 131
            .||:.|.|.|...|||:||                                              
Human    69 TFLEAELPDDFTAHLFMSF---------------------------------------------- 87

  Fly   132 LMPQCSGGGGGIGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPSKTGSVHPMLT 196
                                                  ::|..||               .||:.
Human    88 --------------------------------------SNKFPHS---------------SPMVK 99

  Fly   197 VTPSPLASGPSMFQ-ASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDAVSRILPAIG 260
            ..|:.|:.|..|.: |..|.|   .:||:::.:                            |.: 
Human   100 SKPALLSGGLRMNKGAITPPR---TTSPANTCS----------------------------PEV- 132

  Fly   261 RHCPGSLESGSAQAEKRADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLEFMFRLY 325
                                                :.|||:||||||||.||||||||||||||
Human   133 ------------------------------------IHLKDIVCYLSLLERGRPEDKLEFMFRLY 161

  Fly   326 DTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMTT 390
            |||.||.||::|::.|::|||.|||||.|||:||.|||.|||.|||||.||||||:||.:|||||
Human   162 DTDGNGFLDSSELENIISQMMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTT 226

  Fly   391 IPLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHA 455
            ||||||||::: .:|:||.||||||||:||||||||||||:|:||:||||..||||||||||..|
Human   227 IPLLVLLGLEN-NVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARA 290

  Fly   456 PASCITTYVKSKKPKCGGDLLHH-WVEGNCYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCAS 519
            |.|||.||||||:   ..|::|| ||||||..:|.||.|.:|.|.|:|||.|.||.:.|||:|||
Human   291 PPSCIKTYVKSKR---NTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCAS 352

  Fly   520 SVKKECTLGEYSELIVPPTAICPAVL------------DRQRSV----------------NQAHK 556
            .:|.||..|...:.|:|||.|||.||            :||.:|                |:..:
Human   353 HLKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQR 417

  Fly   557 ATH-------FQITP-PDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGL 613
            |..       .|:|| |.  :.||||||||||||:||:||.|||||:|||||||.||..||..||
Human   418 ANSVTVDGQGLQVTPVPG--THPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL 480

  Fly   614 TLFKDLPRFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIP 678
            ..|:|:|.|||:.|||||||||||:.::...:...|.:.::||||||||||||||||||||||:.
Human   481 NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLM 545

  Fly   679 KLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQR 743
            |::.....::.:|||||..||  .|:..|                                    
Human   546 KILKDIENSTEIMLDRWKFEV--IPNDKD------------------------------------ 572

  Fly   744 QSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQT 808
                                                                             
Human   573 ----------------------------------------------------------------- 572

  Fly   809 LRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQ 873
                                                   ||..|                     
Human   573 ---------------------------------------EKGDP--------------------- 577

  Fly   874 MQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDG 938
                                                                             
Human   578 ----------------------------------------------------------------- 577

  Fly   939 GGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNI 1003
                                                                        |||:|
Human   578 ------------------------------------------------------------VPYSI 582

  Fly  1004 INNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGV 1068
            ||||||:||||:|..:||:.|||:|.|||||||||.||||:.|||||:|:||.||||:||.||||
Human   583 INNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGV 647

  Fly  1069 ALDLANGPHLQGVALLNIPYTHGGSNLWGE---HLSQKRIRKSAGPFGKSKKLRAGDKEFSATSF 1130
            .:||.| ..|:|:|:||||..|||||||||   ..|.:||.|           :..||..:.|  
Human   648 QIDLIN-ISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEK-----------KGSDKRTTVT-- 698

  Fly  1131 NSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPW 1195
            ::.:|..|.||..|:|:||:|||..:.|||:.|||:::||||||||.|:|:|.|:.|||||||||
Human   699 DAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPW 763

  Fly  1196 MQMPCTIKVTHKNQVPMLMAPRSEKGRGFFNLLCS 1230
            ||.|||||:|||||.||||.|..:.|     |.||
Human   764 MQTPCTIKITHKNQAPMLMGPPPKTG-----LFCS 793

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DgkNP_724619.2 DAG_kinase_N 9..313 CDD:291199 66/311 (21%)
EFh 317..386 CDD:238008 50/68 (74%)
EF-hand_7 318..382 CDD:290234 47/63 (75%)
C1 410..459 CDD:237996 39/48 (81%)
C1_1 477..528 CDD:278556 30/51 (59%)
DAGKc 573..694 CDD:214487 75/120 (63%)
DAGKa 1003..1194 CDD:214486 110/193 (57%)
DGKBNP_001337634.1 DAG_kinase_N 6..149 CDD:373103 66/311 (21%)
EFh 153..222 CDD:238008 50/68 (74%)
C1 245..294 CDD:237996 39/48 (81%)
C1_1 310..359 CDD:365894 28/48 (58%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 385..406 3/20 (15%)
DAGKc 440..561 CDD:214487 75/120 (63%)
DAGKa 582..762 CDD:214486 110/193 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..694 9/31 (29%)
Required for association with membranes and function in neurite spine formation. /evidence=ECO:0000305|PubMed:11719522 771..804 15/28 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 221 1.000 Domainoid score I2616
eggNOG 1 0.900 - - E1_KOG1169
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H37875
Inparanoid 1 1.050 621 1.000 Inparanoid score I881
Isobase 1 0.950 - 0 Normalized mean entropy S2700
OMA 1 1.010 - - QHG47969
OrthoDB 1 1.010 - - D633642at2759
OrthoFinder 1 1.000 - - FOG0000241
OrthoInspector 1 1.000 - - otm41616
orthoMCL 1 0.900 - - OOG6_102301
Panther 1 1.100 - - O PTHR11255
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2484
SonicParanoid 1 1.000 - - X838
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.820

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