DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgk and Dgka

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	XP_036011466.1	Gene:	Dgka / 13139	MGIID:	102952	Length:	788	Species:	Mus musculus

Alignment Length:	1252	Identity:	384/1252 - (30%)
Similarity:	499/1252 - (39%)	Gaps:	544/1252 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LSPREFLQLQELASYSTRKLQDVLREFSS-----------PSAASTPKCIPDGD---------ID 57
            :||.:|.|||:...|||:::.|||:.|..           .......|...||:         |.
Mouse    43 ISPEDFAQLQKYIEYSTKRVSDVLKVFDDGEMNRFCQGDVSGTGDVLKVFDDGEMNRFCQGDAIG 107

  Fly    58 FDGFRRFLDAFLDC-EAPLDLAKHLFVSFLKPNVTQAQLHGRALNQMAAISSTAACAPVTSHTKG 121
            :.||.:|:..:|:. |.|..|...||.||                                ||
Mouse   108 YLGFEQFMKMYLEMEEVPHHLCWALFWSF--------------------------------HT-- 138

  Fly   122 SIPNINSIAELMPQCSGGGGGIGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPS 186

Mouse   139 ----------------------------------------------------------------- 138

  Fly   187 KTGSVHPMLTVTPSPLASGPSMFQASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDA 251
                                                        ||::...:|..:|.:
Mouse   139 --------------------------------------------SQVAAEKTKSKANVI------ 153

  Fly   252 VSRILPAIGRHCPGSLESGSAQAEKRADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGRPED 316
                       |                                   |.||.||.:|||.|||||
Mouse   154 -----------C-----------------------------------LSDVYCYFTLLEGGRPED 172

  Fly   317 KLEFMFRLYDTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLD 381
            ||||.|:|||.|.||:||:.|::.|:.|||.|||||.||||||||||||||.|:|.|..|:||||
Mouse   173 KLEFTFKLYDMDRNGILDSTEVEKIILQMMRVAEYLDWDVSELRPILQEMMREMDQDGSGSVSLD 237

  Fly   382 EWQRGGMTTIPLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYT 446
            ||.|.|.||:|||||||:| .|:|:||.|:||.|.|::..||||| ...:.|||:||.|..|||.
Mouse   238 EWVRAGATTVPLLVLLGMD-VTMKDDGNHIWRPKRFTRLVYCNLC-EQSISLGKQGLSCNFCKYI 300

  Fly   447 VHERCVQHAPASCITTYVKSKKPKCGGDLLHHWVEGNCY-GRCSKCRKRIKAYHGITGLTCRWCH 510
            ||:.|...|....::||.||:|..  |...|.||.|.|: |||.:|:|:|:.||.:|||.|.|||
Mouse   301 VHDHCAMKAQPCEVSTYAKSRKDI--GVQSHLWVRGGCHSGRCDRCQKKIRTYHSLTGLHCVWCH 363

  Fly   511 MMLHNRCASSVKKECTLGEYSELIVPPTAICPAVLDRQRSVNQAHKATH---------FQITPPD 566
            :.:|:.|..:|..||..|...:.|:||.:|.|:||...:...  ||.|.         |:|.|..
Mouse   364 LEIHDDCLQAVGPECDCGLLRDHILPPCSIYPSVLVSGQECK--HKTTDDTSLCTPEAFRIEPVS 426

  Fly   567 ELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDG 631
            . :.|||||:|.||||:||..:|.||||:||||||:|| |.||:.||..|||:|:||::.|||||
Mouse   427 N-THPLLVFINLKSGGKQGQSVLWKFQYILNPRQVFDL-KDGPEPGLRFFKDVPQFRILVCGGDG 489

  Fly   632 TVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRASTVMLDRWS 696
            |||||||.:|....|:.|.:.|:|||||||||||||||.||||||:.|::.....:..|.||||.
Mouse   490 TVGWVLETIDKANFATVPPVAVLPLGTGNDLARCLRWGRGYEGENLRKILKDIELSKVVYLDRWF 554

  Fly   697 IEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSI 761
            :||
Mouse   555 LEV-------------------------------------------------------------- 557

  Fly   762 MMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPC 826

Mouse   558 ----------------------------------------------------------------- 557

  Fly   827 NGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVE 891
                                    :|:::||
Mouse   558 ------------------------IPQQNGE---------------------------------- 564

  Fly   892 EAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATP 956

Mouse   565 ----------------------------------------------------------------- 564

  Fly   957 ATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFH 1021
                                                  |...||..|||||||:||||:|..:||
Mouse   565 --------------------------------------KSDPVPSQIINNYFSIGVDASIAHRFH 591

  Fly  1022 LEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNI 1086
            |.|||.|.||||||||||||||:||||:..::||.|.||:.:...|..|||:: ..|:|:|:|||
Mouse   592 LMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESVTVEICGKLLDLSD-LSLEGIAVLNI 655

  Fly  1087 PYTHGGSNLWGE----HLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVD-LSVAIQDFGDRL 1146
            |.|||||||||:    |.....|.::.|.              :|......| |...:.|..|:.
Mouse   656 PSTHGGSNLWGDTKRPHGDTCEINQALGS--------------AAKIITDPDILKTCVPDMSDKR 706

  Fly  1147 IEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVP 1211
            :||:|:|..:.|||:.|.|:::|.|||:|||:..:|.||.|||||||||||.|||||:|||||:|
Mouse   707 LEVVGIEGAIEMGQIYTRLKSAGHRLAKCSEITFQTTKTLPMQIDGEPWMQAPCTIKITHKNQMP 771

  Fly  1212 MLMAPRSEKGR--GFFN 1226
            |||.|.|....  ||::
Mouse   772 MLMGPPSNSYNFFGFWS 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199	43/320 (13%)
		EFh	317..386	CDD:238008	47/68 (69%)
		EF-hand_7	318..382	CDD:290234	43/63 (68%)
		C1	410..459	CDD:237996	23/48 (48%)
		C1_1	477..528	CDD:278556	25/51 (49%)
		DAGKc	573..694	CDD:214487	74/120 (62%)
		DAGKa	1003..1194	CDD:214486	95/195 (49%)
Dgka	XP_036011466.1	DAG_kinase_N	39..169	CDD:405237	43/320 (13%)
		EFh	173..242	CDD:238008	47/68 (69%)
		C1	260..320	CDD:412127	28/60 (47%)
		C1_DGKalpha_rpt2	329..390	CDD:410440	27/60 (45%)
		DAGKc	432..552	CDD:214487	74/120 (62%)
		DAGKa	573..754	CDD:214486	95/195 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2588
eggNOG	1	0.900	-	-		E1_KOG1169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	500	1.000	Inparanoid score	I1352
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	1	1.000	-	-		otm43663
orthoMCL	1	0.900	-	-		OOG6_102301
Panther	1	1.100	-	-	O	PTHR11255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X838
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.820