Protein Alignment Dgk and LOC1274049

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: XP_313113.4
• Gene: LOC1274049 / 1274049
• VectorBaseID: AGAMI1_007133
• Length: 1438
• Species: Anopheles gambiae
• Alignment Length: 1409
• Identity: 291/1409 - (20%)
• Similarity: 439/1409 - (31%)
• Gaps: 613/1409 - (43%)

  Fly     6 AAPKWDKLSPREFLQLQELASYSTRKLQD----VLREFSSPSAASTPKCIPDGDIDFDGFRRFLD 66
            |.|..|.|..|            :|..||    :.:.|...:|..:|:.:.       .||:...
Mosquito   379 AGPPTDTLVTR------------SRSFQDQTNSIPKRFVKSAACYSPRFLA-------RFRKKHQ 424

  Fly    67 AFLDCEAPLD----------LAKHLFVSFLKPNVTQAQLH-GRALNQMAAISS-------TAACA 113
            |.....:|||          |||.|.|            | |...|..::.|.       ..|.|
Mosquito   425 APRRSPSPLDARRAGFNGGELAKLLLV------------HAGTTTNSSSSTSEPTTMAPIRTALA 477

  Fly   114 PVTSHT-KGSIPNINSIAE----LMPQCSGGGGGIGGTGGVAGAEGHAQARSSF--VDKIHGITD 171
            ||..|| .||:.:.::.|.    |:..|       |..|.|..|.|..:...||  .......|.
Mosquito   478 PVLVHTPSGSLTSSSACASGPPLLLTVC-------GMNGEVDDAAGTVERSHSFDCTTAAAAATP 535

  Fly   172 KLHHSLGGHLS-----------------------------HDPSKTGS----------------- 190
            .:....|.||:                             .|.::.||
Mosquito   536 TVGRHFGHHLTVASANELLLTCVEPRRVVSYDDVSGFSFIDDDNEGGSEPNGSTTASAVGAALVG 600

  Fly   191 -VHPMLTVTPSPLASGPSMFQ-----ASNPARRSVDSSPSHSATNH--SQMSRNSSKKSS--NSV 245
             .:...|.:.||..:..|..|     |:...|.....:.|||.|.|  .::.|...|.|.  :..
Mosquito   601 YTNEPTTTSVSPTGNADSDTQRQRQRAATVGRAEQQGALSHSPTQHLLGRIYRQMRKCSMGWSKT 665

  Fly   246 NCKIDAVSRILPAI--------GRHCPGSLESGSA---------QAEKRADIK------------ 281
            .|::.....|...|        ..:.|....|||.         :.:|..|.|
Mosquito   666 GCRVRRARSISEEITTENRYRDDEYVPRGESSGSGTHSKPDSAHKPDKDKDKKDKDKEERDEETI 730

  Fly   282 ---------------------------LLARKLSHF----DPLTL--------KVPLKD--VVCY 305
                                       ||...|..|    ||...        :|.|:|  .|..
Mosquito   731 KVFDGNCSYRRRIFRAINVPRTCSLEQLLTTALRAFHIARDPNLFFLTDVYGDEVRLQDPTPVPG 795

  Fly   306 LSLLEAGRPEDKLEF--------MFRLY----DTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSE 358
            |..:|..||...|.|        ..|:|    ..::..|:...:.|..|..::.         ..
Mosquito   796 LHRVEGKRPAIYLRFRDKENDHGFVRVYPGKLQVENAYVIIPVDNDTTVKDLIC---------ES 851

  Fly   359 LRPI-LQEMMVEIDYD----------ADGTVSLDE--WQRGGMTTIPLLVLLGVDS--------- 401
            |:.. ||...:| ||.          .:..:|.:|  |:        ::..||.||
Mosquito   852 LKKFGLQSHQIE-DYRCSEILLDRGVTERVLSWNERPWE--------IMKQLGKDSIRQMELMRF 907

  Fly   402 -TTLKEDGIHVWRLKHFSKPAYCNLCL---NMLVGLGKKGLCCVLCKYTVHER------CVQHAP 456
             ..||:|            |...||.|   |:..||.::....:|.::...|.      .:.:..
Mosquito   908 YLQLKQD------------PHGPNLALFVGNLPPGLSQRNYEHILTEFLGFENKFSSIGPIYYEY 960

  Fly   457 ASCITTYVKSKKPKCGGDLLHHWVEGNCYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSV 521
            .|.:.||                         ....|.::|:..:........|:::
Mosquito   961 GSLVITY-------------------------ENASKAVRAFQALRESKYEEKHLLV-------- 992

  Fly   522 KKECTLGEYSELIVP---PTAICPAVLDRQRSVNQAHKATHFQITPPDELSCPLLVFVNPKSGGR 583
                       |::|   |:.: ||.:.                        |||||||.||||.
Mosquito   993 -----------LLLPNIEPSMV-PAGVQ------------------------PLLVFVNVKSGGC 1021

  Fly   584 QGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSI---EL 645
            ||..::..|:.:|||.||:||..|||..||.:|:.:..::::.||||||:||||:.:|::   ..
Mosquito  1022 QGLELISSFRKLLNPYQVFDLDNGGPLPGLYVFRHIQDYKILVCGGDGTIGWVLQCLDNVGQDSE 1086

  Fly   646 ASQPAIGVIPLGTGNDLARCLRWGGGYEGENIP-KLMDKFRRASTVMLDRWSIEVTNTPHSDDMR 709
            .|.|...::||||||||||.||||.||.|...| .|:.....|..:.||||::........:|..
Mosquito  1087 CSSPPCAIVPLGTGNDLARVLRWGAGYTGGEDPLNLLRDVIDAEEIRLDRWTVVFHPEDKPEDAT 1151

  Fly   710 PKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETM 774
            ||...:|..:|                  ::||:|.:|
Mosquito  1152 PKAQPNSTGKK------------------KKIQQQQQQ--------------------------- 1171

  Fly   775 ATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSH 839
                                                                             
Mosquito  1172 ----------------------------------------------------------------- 1171

  Fly   840 AAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATP---VGS 901
                                        .|.:||:|||||||||.........|..|.|   ||.
Mosquito  1172 ----------------------------QQQQQQLQQQQQQQQQNQQHHHPSVAIVANPAQVVGG 1208

  Fly   902 NQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPN 966
            .||:::||
Mosquito  1209 AQSEDNSQ--------------------------------------------------------- 1216

  Fly   967 AASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKF 1031
                                              ..::||||.:|:||.:|:.||..||:||:||
Mosquito  1217 ----------------------------------IFVMNNYFGIGIDADLCLDFHNAREENPNKF 1247

  Fly  1032 NSRMKNKLWYFEYATSETFAAS-CKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNL 1095
            |||:.||..|.:....:..... .|.||:.:.:..||..::|   |.::|:.:|||.....|:|.
Mosquito  1248 NSRLHNKGVYVKMGLRKMVGRKMVKELHKELRLEVDGKVVEL---PPVEGIIILNILSWGSGANP 1309

  Fly  1096 WGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQ 1160
            ||..                     .:.:||.            .:..|.::||:|:...:|:||
Mosquito  1310 WGPE---------------------KEDQFSK------------PNHWDGMLEVVGVTGVVHLGQ 1341

  Fly  1161 VRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKV 1204
            :::||| |..|:||...:.|......|:|:|||||:|.|..:.|
Mosquito  1342 IQSGLR-SAMRIAQGGHIKIHLHSDIPVQVDGEPWVQSPGDVVV 1384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196	28/129 (22%)
		EFh	317..386	CDD:238008	16/93 (17%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	15/73 (21%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	3/50 (6%)
		DAGKc	573..694	CDD:214487	59/124 (48%)
		DAGKa	1003..1194	CDD:214486	58/191 (30%)
LOC1274049	XP_313113.4	C1_DGKtheta_typeV_rpt1	6..60	CDD:410353
		C1_DGKtheta_typeV_rpt2	64..120	CDD:410354
		C1_DGKtheta_typeV_rpt3	135..197	CDD:410404
		RA1_DAGK-theta	729..813	CDD:340631	16/83 (19%)
		RA2_DAGK-theta	818..912	CDD:340481	18/111 (16%)
		DAGKc	1011..1136	CDD:214487	59/124 (48%)
		DAGK_acc	1219..1374	CDD:459866	58/191 (30%)