Protein Alignment Dgk and rdgA

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: XP_061505282.1
• Gene: rdgA / 1271726
• VectorBaseID: AGAMI1_013122
• Length: 1554
• Species: Anopheles gambiae
• Alignment Length: 1359
• Identity: 290/1359 - (21%)
• Similarity: 416/1359 - (30%)
• Gaps: 610/1359 - (44%)

  Fly     1 MNIGIAAPKWD------KLSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDGDIDFD 59
            :..|:.||.:|      ::|||...::....|          ...|.|::.::|
Mosquito   300 LTFGLEAPAYDYASLFQRVSPRRRPRVDGEGS----------TLLSPPASIASP----------- 343

  Fly    60 GFRRFLDAFLDCEAPLDLAKHLFVSFLKPNVTQAQLHGRALNQMAAISSTAACAPVTSHTKGSIP 124
                       |...|.|      |..||:..:.|...:..........||..|
Mosquito   344 -----------CRITLTL------SPTKPDEEEDQQQQQQQQSQQTELRTAEIA----------- 380

  Fly   125 NINSIAELMPQCSGGGGGIGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPSKTG 189
                   ||....||...:|..|     |.|
Mosquito   381 -------LMLPVDGGSSELGAVG-----EAH---------------------------------- 399

  Fly   190 SVHPMLTVTPSPLASGPSMFQASNPARRSVD----------SSPSHSATNHSQMSRNSSKK---- 240
            ...|.|.||..|...|......|...|||:.          .|...:.:|.|:....:..:
Mosquito   400 DTRPPLPVTVEPAEDGVEPPAPSRTRRRSISRQEAIIVEPTGSSLENVSNASESRPTTPPRPVPD 464

  Fly   241 ---SSNSVNCK--------------------IDAVSRILPAIGRHCPGSLESG---------SAQ 273
               ||:.::|:                    |.|.:.:.||..:..|.. .:|         ||.
Mosquito   465 IHTSSDELDCQQQQQQRDRAAQRGRAASMGPILAGATVRPAPPQESPPP-SAGPTVQLPPPTSAA 528

  Fly   274 AEKRADI---------KLLARKLSHFDPLTLKV---------PLKDVVCYLSLLEAGRPEDKLEF 320
            ..:.||.         .|...:.:..|....||         |..|..| |:||.
Mosquito   529 TSQAADFVRDIYLQVPDLKRDRAASVDSCFTKVTGAKTEELQPPPDGAC-LNLLA---------- 582

  Fly   321 MFRLYDTDSNGVLDTAEMDAIV-------NQMMAVAEYL------------GWDVSELRPILQEM 366
                  ..|:|.:.:..:|.::       .:.:|:|...            |..|:.|.|
Mosquito   583 ------VPSSGAVRSRSVDIVLPTEEQARYKALALAGPAGSAGQQGGGGSGGGPVAHLAP----- 636

  Fly   367 MVEIDYDADGTVSLDEWQRGG------MTTIPLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYC-- 423
                     |.:      |||      :...|       |.:.....|.|:|.....|....|
Mosquito   637 ---------GII------RGGDPHGRQIRCTP-------DWSENAVSGDHLWVPTSVSGDCCCVG 679

  Fly   424 -NLCLNMLVGLGKKG--LCCVLCKYTVHERCV----QHAPASCITTY--VKSKKPKCGGDLLHHW 479
             |.|.       |.|  :.|..||...|..|:    :.:...|..|:  |..::.:......|||
Mosquito   680 DNECT-------KHGPRMKCAACKIIAHASCISVLMERSHLQCKPTFRDVGVRQYREQTKTTHHW 737

  Fly   480 VEGNC-YGRCSKCRKRIKA-----YHGITGLTCRWCHMMLHNRCA----SSVKKECTLGEYSELI 534
            |.... .|:|.:|.|.::|     ...|..|:|.||....||:.|    ..:.:|||||.:..::
Mosquito   738 VHRRTEKGKCKQCGKSLQAKLTFSSKEIVALSCAWCKASYHNKEACFNPERIGEECTLGTHRSIV 802

  Fly   535 VPPTAICPAVLDR------------QRSVNQAHKATH-------FQITP-PDELSCPLLVFVNPK 579
            |||:.|  ..|.|            |:..::|.|...       |.|.| |.....|:|||:|||
Mosquito   803 VPPSWI--VKLPRKGNFKSSLRKTPQKKKSKAGKKVSIPREPRTFVIKPIPTANLTPVLVFINPK 865

  Fly   580 SGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIE 644
            |||.||.::|:|||::||||||:||::|||:.||.||:.:|:.|::.|||||||||||..:|.|.
Mosquito   866 SGGNQGAKLLQKFQWLLNPRQVFDLTQGGPRMGLELFRKVPQLRILACGGDGTVGWVLSVLDQIN 930

  Fly   645 LASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMR 709
            ....||:||:||||||||||.|.|||||..|.|.|::.....:.||:|||||::|
Mosquito   931 FVPPPAVGVLPLGTGNDLARALGWGGGYTDEPIGKILTNIGNSDTVLLDRWSLKV---------- 985

  Fly   710 PKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETM 774
                                                                             
Mosquito   986 ----------------------------------------------------------------- 985

  Fly   775 ATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSH 839
                                                                             
Mosquito   986 ----------------------------------------------------------------- 985

  Fly   840 AAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQS 904
                                                                             
Mosquito   986 ----------------------------------------------------------------- 985

  Fly   905 DNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAAS 969
                                        ||.......|||
Mosquito   986 ----------------------------EPNTSVPNTGDG------------------------- 997

  Fly   970 SVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSR 1034
                                     || .:|.|::|||||:||||.|.::||..||.:|.|||||
Mosquito   998 -------------------------KD-NLPLNVVNNYFSLGVDAHIALEFHEAREAHPEKFNSR 1036

  Fly  1035 MKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPH-LQGVALLNIPYTHGGSNLWGE 1098
            ::||::|.:....:......|.|.|.:.:.|||..|......| :..:..||||...||::.|
Mosquito  1037 LRNKMFYGQAGGKDLLKRKWKGLAEFVTLECDGKDLTPKLKEHKVHAIVFLNIPSYGGGTHPW-- 1099

  Fly  1099 HLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRT 1163
                   .||.|.|.            .||.              |.:|||:|| ....:..::.
Mosquito  1100 -------NKSGGQFE------------PATD--------------DGMIEVVGL-TTYQLPLLQA 1130

  Fly  1164 GLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSEKGR 1222
            |  ..|..:.||....|.|.||.|||:|||.....|..|::|..|:..||  .:.:.||
Mosquito  1131 G--GHGTCITQCRTARIVTSKTIPMQVDGEACKLNPSNIELTLLNKAVML--AKKKPGR 1185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196	18/113 (16%)
		EFh	317..386	CDD:238008	10/87 (11%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	17/75 (23%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	20/60 (33%)
		DAGKc	573..694	CDD:214487	71/120 (59%)
		DAGKa	1003..1194	CDD:214486	63/191 (33%)
rdgA	XP_061505282.1	None