Protein Alignment Dgk and Dgk

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: XP_061496901.1
• Gene: Dgk / 1270300
• VectorBaseID: AGAMI1_012882
• Length: 1127
• Species: Anopheles gambiae
• Alignment Length: 1267
• Identity: 762/1267 - (60%)
• Similarity: 871/1267 - (68%)
• Gaps: 195/1267 - (15%)

  Fly     9 KWDKLSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDGDIDFDGFRRFLDAFLDCEA 73
            ||:||||.||.|||:||||||:|||:||:||.||:..|..:..||||||:||||:|||:|||||.
Mosquito     7 KWEKLSPSEFQQLQDLASYSTKKLQNVLQEFCSPATPSASRFHPDGDIDYDGFRKFLDSFLDCET 71

  Fly    74 PLDLAKHLFVSFLKPNVTQAQ----LHGRALNQMAAISSTAACAPVTSHTKGSIPNINSIAEL-M 133
            |.||::|||:|||:|.:.|||    .||:||:|||||||.|||||||||.:|||||:|||.:: .
Mosquito    72 PDDLSQHLFISFLQPALYQAQQQQHSHGKALSQMAAISSNAACAPVTSHNRGSIPNLNSIVDIPT 136

  Fly   134 PQCSGGGGGIGGTGGVAGAEGHAQARSSFVDKIHGITDKL----HHSL-GGHLSHDPSKTGSVHP 193
            ||.|                 ....|:|||::|||:||||    |..| ||..|.:..|.|:|||
Mosquito   137 PQPS-----------------QESQRNSFVERIHGLTDKLQSLGHLGLDGGGDSSNKGKCGTVHP 184

  Fly   194 MLTVTPSPLASGPSMFQASNPARRSVDSSPSHS-ATNHSQMSRNSSKKSSNSVNCKIDAVSRILP 257
            ||||||||:...|.:.||  |.|||.||||||| :.:|||:|||||:||:|||||:|:
Mosquito   185 MLTVTPSPMGCTPPILQA--PFRRSADSSPSHSHSHSHSQISRNSSRKSNNSVNCRIE------- 240

  Fly   258 AIGRHCPGSLESGSAQAEKRADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLEFMF 322
                                 |::|:.||.|..|||.||||||||||||||||||||||||||||
Mosquito   241 ---------------------DVRLIPRKQSFLDPLLLKVPLKDVVCYLSLLEAGRPEDKLEFMF 284

  Fly   323 RLYDTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGG 387
            ||||||.||||||.|.||||||||:|||||||||||||||||:||.|||||.||.|||:||||||
Mosquito   285 RLYDTDGNGVLDTTETDAIVNQMMSVAEYLGWDVSELRPILQDMMTEIDYDGDGCVSLEEWQRGG 349

  Fly   388 MTTIPLLVLLGVDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCV 452
            :||||||||||||: ||||||.|||||||||||||||:|||||||||||||||||||||||||||
Mosquito   350 LTTIPLLVLLGVDN-TLKEDGYHVWRLKHFSKPAYCNMCLNMLVGLGKKGLCCVLCKYTVHERCV 413

  Fly   453 QHAPASCITTYVKSKKPKCGGDLLHHWVEGNCYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRC 517
            |.||||||.|||||||.|......||||||||||||||||||||||:||||||||||.|||||:|
Mosquito   414 QRAPASCIATYVKSKKSKATATFQHHWVEGNCYGRCSKCRKRIKAYNGITGLTCRWCRMMLHNKC 478

  Fly   518 ASSVKKECTLGEYSELIVPPTAICPAVLDRQRSVN-------QAHKATHFQITPPDELSCPLLVF 575
            |:.||.||||||::.|::|||||||||||||:|:|       ......||||| .|...||||||
Mosquito   479 ATLVKAECTLGEFANLVLPPTAICPAVLDRQKSINFTTNKGKSVPSTIHFQIT-SDPSWCPLLVF 542

  Fly   576 VNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAM 640
            :||||||||||||||||||:||||||||||||||.||||:|||:|.|:|||||||||||||||||
Mosquito   543 INPKSGGRQGDRILRKFQYLLNPRQVYDLSKGGPLEGLTMFKDVPNFKVICCGGDGTVGWVLEAM 607

  Fly   641 DSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRASTVMLDRWSIEVTNTPHS 705
            |||.|.:||:|||||||||||||||||||||||||:|||::||..|||.||||||||||.|.|.:
Mosquito   608 DSIVLQTQPSIGVIPLGTGNDLARCLRWGGGYEGESIPKILDKINRASVVMLDRWSIEVKNNPLA 672

  Fly   706 DDMRP--------KVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIM 762
            .:..|        ||||..|:|||||||..::.:||:::.::|.:..:.:          :|.:.
Mosquito   673 AEETPTATTMPGHKVTLSENVQKVIELSHRIIAEKSVIQAYDEEENSTNR----------ATDVP 727

  Fly   763 MASKTETEMETMATMEFGSSTTTTNRTTTTKSISMST-FET-QCLQQTLRTAMSSSSSNTSSGSP 825
            :                   ..|.|.||...::|.:. |.. .....|.|.|..:::...:..:|
Mosquito   728 L-------------------PPTANGTTQRAAVSDNNGFAIGPDAAGTARVAAMTATPPPTPTTP 773

  Fly   826 CNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAV 890
            ..|..|..|.::...|..|:......|..:|                           |.|:|..
Mosquito   774 FAGGADGPTVMEGFIAEHANRGAVDPPLTNG---------------------------GATTLVS 811

  Fly   891 EEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPAT 955
            ..|..                                    ||..||   ....|.:||::.|..
Mosquito   812 SIAGV------------------------------------DEDDDD---VAANTGTNGSAPPVD 837

  Fly   956 --PATPITPTTPNAA-----SSVLQQQQQQHLQFEQQQKP------------IKVQSDKDCTVPY 1001
              |.|........|.     ||..||||..|.......||            ||.|...:.||||
Mosquito   838 NGPCTNDDDAAQRAEDDTVNSSYQQQQQHHHSNGNATDKPRPEKKIIDLPKLIKPQVGSEFTVPY 902

  Fly  1002 NIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCD 1066
            ||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||.:|||||
Mosquito   903 NIVNNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHEYLEIVCD 967

  Fly  1067 GVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFN 1131
            ||:|:|||||.|||:|||||||||||||||||||||||:||  |||  .|||:..|||.||.|||
Mosquito   968 GVSLELANGPQLQGIALLNIPYTHGGSNLWGEHLSQKRMRK--GPF--RKKLKNSDKELSANSFN 1028

  Fly  1132 SVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWM 1196
            |||||:||||.||..|||||||||||||||||||||||||||||||||:.|||||||||||||||
Mosquito  1029 SVDLSIAIQDIGDSKIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIMTTKKTFPMQIDGEPWM 1093

  Fly  1197 QMPCTIKVTHKNQVPMLMAPRSEKGRGFFNLL 1228
            |.|||||:|||||||||||||||||.|||:.|
Mosquito  1094 QGPCTIKLTHKNQVPMLMAPRSEKGSGFFSFL 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196	75/111 (68%)
		EFh	317..386	CDD:238008	59/68 (87%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	60/64 (94%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	44/50 (88%)
		DAGKc	573..694	CDD:214487	103/120 (86%)
		DAGKa	1003..1194	CDD:214486	166/190 (87%)
Dgk	XP_061496901.1	None