Protein Alignment Dgk and Dgkepsilon

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: XP_061503299.1
• Gene: Dgkepsilon / 1270295
• VectorBaseID: AGAMI1_012361
• Length: 550
• Species: Anopheles gambiae
• Alignment Length: 853
• Identity: 190/853 - (22%)
• Similarity: 274/853 - (32%)
• Gaps: 356/853 - (41%)

  Fly   390 TIPLLVLLGV------DSTTLKEDGI--------HVWR-LKHFSKPAYCNLCLNMLVGLGKKGLC 439
            |:.:.||||:      ....||||.:        |.|: :|..::...|::|   ...:...|..
Mosquito    20 TLFVSVLLGLGLMWLAGRYFLKEDVVYIPDNCRRHAWKSVKLLARSCVCSVC---DTSMSSNGHF 81

  Fly   440 CVLCKYTVHERCVQHAPAS--CITTYVKSKKPKCGGDLLHHWVEGN--CYGRCSKCRKRI--KAY 498
            |..|.......||:.|...  |....::::... |....|.||:||  ....|..||:.|  .:.
Mosquito    82 CESCGVCSDNGCVRKADEKFPCKQLRIRTRADD-GSTCRHLWVKGNLPLGSECCVCREDIDQTSE 145

  Fly   499 HGITGLTCRWCHMMLHNRCASSVKKE-CTLGEYSELIVPPTAICPAVLDRQRSVNQAHKATHFQI 562
            .|:.|..|.||..|.|::|.|.|... |..|.:.|:|.||..|   :..|.:...:.|..   .|
Mosquito   146 LGLFGQRCAWCQRMAHDKCFSEVSSTLCDFGPFKEMIFPPKCI---LASRSKVAQKVHLT---GI 204

  Fly   563 TPPDELS--CPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGL--TLFKDLPRFR 623
            .||:..:  .||:|..|.|||....|:::...:.:|:|.||::|.:.||.|.|  .:.....|.|
Mosquito   205 IPPEWKANWRPLIVVANSKSGSSGADQVVALMRGILHPLQVFELGQHGPHEALQWAIHASPTRCR 269

  Fly   624 VICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIP-KLMDKFRRA 687
            ::..||||||||||..:..:::...|.:.::||||||||:|.|.||.....|..| ..:.:..:|
Mosquito   270 ILVAGGDGTVGWVLNTILQMKVEPHPEVAILPLGTGNDLSRVLGWGAEGPDEFDPIDYLTRIAQA 334

  Fly   688 STVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSM 752
            .||.||||..|: ||            ||:                 :.||.
Mosquito   335 ETVQLDRWLAEI-NT------------HSS-----------------LARFH------------- 356

  Fly   753 GTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSS 817
                                                                             
Mosquito   357 ----------------------------------------------------------------- 356

  Fly   818 SNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQ 882
                                             ||
Mosquito   357 ---------------------------------VP------------------------------ 358

  Fly   883 QGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKS 947
                             |.:||
Mosquito   359 -----------------GFSQS------------------------------------------- 363

  Fly   948 NGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGV 1012
                                          :|.                      .:.||.||||
Mosquito   364 ------------------------------RHF----------------------YMYNYLSVGV 376

  Fly  1013 DAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPH 1077
            ||.:.:.||..||.:.:.::||..|||.|..:.|.:.....|..|.:.:::..|||.:||   |.
Mosquito   377 DALVTLNFHKARESSFYLYSSRFVNKLLYLCFGTQQVVQQDCVELEKHLDLYLDGVRIDL---PS 438

  Fly  1078 LQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSV--AIQ 1140
            ||.|.:|||.....|..||                              ..|.||...|:  .|.
Mosquito   439 LQSVVVLNIDSWGAGVKLW------------------------------EMSKNSPTHSIMKEIH 473

  Fly  1141 DFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKVT 1205
            ...|.::||.|:.:..|:.|::.|| :...||.|...|.|..|:|.|||.|||||||.||.|.:.
Mosquito   474 SISDGILEVFGVVSSFHIAQLQVGL-SKPVRLGQAKSVRIVLKRTLPMQADGEPWMQSPCDINIQ 537

  Fly  1206 HKNQVPML 1213
            |..|..||
Mosquito   538 HYGQATML 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008
		C1_DGKbeta_rpt1	403..468	CDD:410395	16/75 (21%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	20/55 (36%)
		DAGKc	573..694	CDD:214487	46/123 (37%)
		DAGKa	1003..1194	CDD:214486	61/192 (32%)
Dgkepsilon	XP_061503299.1	None