Protein Alignment Dgk and Dgkq

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: XP_011247694.1
• Gene: Dgkq / 110524
• MGIID: 102918
• Length: 939
• Species: Mus musculus
• Alignment Length: 1165
• Identity: 201/1165 - (17%)
• Similarity: 291/1165 - (24%)
• Gaps: 699/1165 - (60%)

  Fly   410 HVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCIT---TYVKSKKPKC 471
            |.:|....:||.:|:||.:.:.||.  |..|.:|.:..||:|::.....|.:   :.|:.....|
Mouse    55 HSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCLKQVKTPCTSIAPSLVRVPVAHC 117

  Fly   472 GGDL-------------------------------------------------------LHHWVE 481
            .|.|                                                       .|||.|
Mouse   118 FGSLGLYKRKFCVVCRKSLEVPAFRCEVCELHVHPDCVPFACSDCRQCHQDGQQDYDTYHHHWRE 182

  Fly   482 GN--CYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSVKKECTLGEYSELIVPPTAI---- 540
            ||  ...||..|||...:...:.|:.|.||.:..|:.|::::..|||.|....:::||:.:
Mouse   183 GNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSVCSTALAPECTFGRLRSMVLPPSCVRLLS 247

  Fly   541 ----------------------------------------------------------------- 540
                                                                             
Mouse   248 RNFSKMHCFRIPETMVLELGDGDDGVDGSAAIGTGREVLTATESTKQTLKIFDGNDSMRKNQFRL 312

  Fly   541 ---------------------------------------------------------CP------ 542
                                                                     ||
Mouse   313 VTVSRLARNEEVMEAALRAYYISEDPKDFQLQALPLSGNAQALGKAGTTEEEASKGSCPRDSVPE 377

  Fly   543 ----------------------------------------------------------------- 542
                                                                             
Mouse   378 AWVIRSLPRTQEILKIYPGWLKVGVAYVSIRVNSQSTARSVVQEVLPLFGQQVEDKERFQLIEVL 442

  Fly   543 ---------------AVLD-----RQRSVNQAHKATHFQITP----------------------- 564
                           .:||     ||.||.|..: |.|.:..
Mouse   443 MSSRQVQRTVLADEEPLLDRLWDIRQTSVRQVSQ-TRFYVAETRATAPRVSLFVGGLPPGLSPQD 506

  Fly   565 ------------------------------------------------------------PDELS 569
                                                                        ||.||
Mouse   507 YSNLLHEAMATKAAVVSVSHVYSLQGAVILDVTCFAEAERLYMLARDTAVHGRPLTALVLPDVLS 571

  Fly   570 ------------CPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRF 622
                        |||||||||||||.:|..:|..|:.:|||.||::|:.|||..|..||..:|.|
Mouse   572 STSQHTKLPPDCCPLLVFVNPKSGGLKGRELLCSFRKLLNPHQVFELTNGGPLPGFHLFSQVPSF 636

  Fly   623 RVICCGGDGTVGWVLEAMDSIE---LASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKF 684
            ||:.|||||||||||.|::...   ...:|::.::||||||||.|.||||.||.||:...::...
Mouse   637 RVLVCGGDGTVGWVLAALEETRRHLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLVSV 701

  Fly   685 RRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVA 749
            ..|..|::|||:|.:
Mouse   702 DEADAVLMDRWTILL-------------------------------------------------- 716

  Fly   750 TSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMS 814
                                                                             
Mouse   717 ----------------------------------------------------------------- 716

  Fly   815 SSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQ 879
                            ||. |:||
Mouse   717 ----------------DAH-EIDS----------------------------------------- 723

  Fly   880 QQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDG 944
                                            .:||::             |.||
Mouse   724 --------------------------------TENNVV-------------ETEP---------- 733

  Fly   945 TKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFS 1009
                                                       |..||           :|||..
Mouse   734 -------------------------------------------PKIVQ-----------MNNYCG 744

  Fly  1010 VGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLAN 1074
            :|:||.:.:.||..||:.|.||.||..||..|......:  .:..::||:.|.:..:...::|
Mouse   745 IGIDAELSLDFHQAREEEPGKFTSRFHNKGVYVRVGLQK--ISHSRSLHKEIRLQVEQQEVEL-- 805

  Fly  1075 GPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAI 1139
             |.::|:..:|||....|::|||..                     .|..|.....:
Mouse   806 -PSIEGLIFINIPSWGSGADLWGSD---------------------NDSRFEKPRID-------- 840

  Fly  1140 QDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMP 1199
                |.|:||:|:...:|||||:.||| ||.|:||.|...:...|..|:|:|||||:|.|
Mouse   841 ----DGLLEVVGVTGVVHMGQVQGGLR-SGIRIAQGSYFRVTLLKATPVQVDGEPWVQAP 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008
		C1_DGKbeta_rpt1	403..468	CDD:410395	17/60 (28%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	20/52 (38%)
		DAGKc	573..694	CDD:214487	61/123 (50%)
		DAGKa	1003..1194	CDD:214486	57/190 (30%)
Dgkq	XP_011247694.1	C1_DGKtheta_typeV_rpt1	54..107	CDD:410353	16/53 (30%)
		C1_DGKtheta_typeV_rpt2	111..166	CDD:410354	3/54 (6%)
		C1_DGKtheta_typeV_rpt3	178..240	CDD:410404	21/61 (34%)
		RA1_DAGK-theta	293..386	CDD:340631	2/92 (2%)
		RA2_DAGK-theta	389..483	CDD:340481	9/94 (10%)
		DAGKc	587..711	CDD:214487	61/123 (50%)
		DAGKa	738..890	CDD:214486	58/201 (29%)