Protein Alignment Dgk and Dgkz

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: XP_006498600.1
• Gene: Dgkz / 104418
• MGIID: 1278339
• Length: 1137
• Species: Mus musculus
• Alignment Length: 857
• Identity: 193/857 - (22%)
• Similarity: 287/857 - (33%)
• Gaps: 380/857 - (44%)

  Fly   408 GIHVWRLKHFSKPAYCNL----CLNMLVGLGKKGLCCVLCKYTVHERCVQHAPA---SCITTYVK 465
            |.|:|...:.|.. :|.:    |:..::........|..||..||.:|::....   .|..::.:
Mouse   290 GEHIWFETNVSGD-FCYVGEQHCVAKMLPKSAPRKKCAACKIVVHTQCIKQLEKINFRCKPSFRE 353

  Fly   466 S-----KKPKCGGDLLHHWVEGNCY-GRCSKCRKRIK---AYHG--ITGLTCRWCHMMLHNRCA- 518
            |     ::|..   :.||||..... |:|..|.|..:   .:|.  |..::|.||....|::.:
Mouse   354 SGSRNVREPTF---VRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSC 415

  Fly   519 ---SSVKKECTLGEYSELIVPPTAICPAVLDRQRSVNQAHKATH--------------------F 560
               ..:::.|:||.::.:::|||.|..|  .|.::..:|.|...                    |
Mouse   416 FMMQQIEEPCSLGVHAAVVIPPTWILRA--RRPQNTLKASKKKKRASFKRRSSKKGPEEGRWRPF 478

  Fly   561 QITP-PDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRV 624
            .|.| |..|..||||||||||||.||.:|::.|.:.||||||:|||:|||:|.|.:::.:...|:
Mouse   479 IIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPREALEMYRKVHNLRI 543

  Fly   625 ICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRAST 689
            :.|||||||||:|..:|.:.|...|.:.::||||||||||.|.|||||..|.:.|::......:.
Mouse   544 LACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNV 608

  Fly   690 VMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGT 754
            |.||||.:.....|.
Mouse   609 VQLDRWDLRAEPNPE-------------------------------------------------- 623

  Fly   755 AASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSN 819
                                                                             
Mouse   624 ----------------------------------------------------------------- 623

  Fly   820 TSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQG 884
                                                                             
Mouse   624 ----------------------------------------------------------------- 623

  Fly   885 VTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNG 949
                       |.|                                  |.:|||.
Mouse   624 -----------AGP----------------------------------EERDDGA---------- 633

  Fly   950 NSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDA 1014
                                                       :|:   :|.::.|||||:|.||
Mouse   634 -------------------------------------------TDR---LPLDVFNNYFSLGFDA 652

  Fly  1015 AICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQ 1079
            .:.::||..||.||.|||||.:||::|...|.|:....|.|:|.:.|.:||||  :||.  |.:|
Mouse   653 HVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDG--MDLT--PKIQ 713

  Fly  1080 G-----VALLNIPYTHGGSNLW---GEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLS 1136
            .     :..||||....|:..|   |||                       .:|..
Mouse   714 DLKPQCIVFLNIPRYCAGTMPWGHPGEH-----------------------HDFEP--------- 746

  Fly  1137 VAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCT 1201
               |...|..:||||. ....:..::.|  ..|.||.||.||::.|.|..|:|:||||.......
Mouse   747 ---QRHDDGYLEVIGF-TMTSLAALQVG--GHGERLTQCREVLLTTAKAIPVQVDGEPCKLSASR 805

  Fly  1202 IKVTHKNQVPML 1213
            |::..:||..|:
Mouse   806 IRIALRNQATMV 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008
		C1_DGKbeta_rpt1	403..468	CDD:410395	14/71 (20%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	15/60 (25%)
		DAGKc	573..694	CDD:214487	62/120 (52%)
		DAGKa	1003..1194	CDD:214486	66/198 (33%)
Dgkz	XP_006498600.1	C1_DGKzeta_rpt1	282..355	CDD:410399	13/65 (20%)
		C1_DGKzeta_rpt2	365..439	CDD:410445	19/73 (26%)
		DAGKc	492..613	CDD:214487	62/120 (52%)
		DAGKa	641..798	CDD:214486	66/198 (33%)
		Ank_2	1003..1097	CDD:463710
		ANK repeat	1031..1064	CDD:293786
		ANK repeat	1066..1091	CDD:293786