Protein Alignment Dgk and dgkk

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: XP_004916836.1
• Gene: dgkk / 100496859
• XenbaseID: XB-GENE-22063413
• Length: 1154
• Species: Xenopus tropicalis
• Alignment Length: 1048
• Identity: 277/1048 - (26%)
• Similarity: 442/1048 - (42%)
• Gaps: 237/1048 - (22%)

  Fly   250 DAVSRI----LP---AIGRHCPGSLESGSAQAEKRADIK-LLARKLSHFDPLTLKVPLKDVVC-- 304
            |:||.:    ||   |.|.      ||..::.|::..|. .|.||:|....:..|..:|:.:.
 Frog    17 DSVSSLDSDKLPTAEATGE------ESSDSEGEEQEGISHKLIRKVSTSGQIRSKKSVKEGILLK 75

  Fly   305 -----------YLSLLEAGR----PEDKLEFMFRLYDTDSNGVLDTAEMDAIVNQMMAVAEYLGW 354
                       |..|  .||    .:|....:|...|.....|.:|:..:  :|....|
 Frog    76 QTSSFQRWKRRYFKL--RGRTLYYAKDSKSLIFDEVDLSDASVAETSTKN--INNSFTV------ 130

  Fly   355 DVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMTTIPLLVLLGVDSTTLKE---------DGIH 410
             ::..|.::        ..|:....:::|         :..|..|....|.|         .|:|
 Frog   131 -ITPFRKLI--------LCAENRKEMEDW---------IGALKSVQKWELNETTQFNMEHFSGMH 177

  Fly   411 VWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITTYVKSKKPKCGGDL 475
            .|.....::|.:||:|...|.|:...||.|.:||:..|:||...|..:|..|.:.|    .|.|:
 Frog   178 NWYACSHARPTFCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLAS----VGNDI 238

  Fly   476 L---------HHWVEGN--CYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSVKKECTLGE 529
            :         |.|:|||  ...:|..|.|...:...:....|.||..::|..|...:.|.|.||.
 Frog   239 IEDEDGVSMPHQWLEGNLPVSAKCEVCDKTCGSVRRLQDWRCLWCKAIVHTSCKEQLGKICPLGP 303

  Fly   530 YSELIVPPTAICPAVLDRQRSVNQAHKATHFQITPPDELSCPLLVFVNPKSGGRQGDRILRKFQY 594
            ....|:||.|:           |.......::.|.|...:.|||||||.|||..||.:.||||:.
 Frog   304 CRVSIIPPIAL-----------NSIDSDGFWKATSPASCASPLLVFVNSKSGDNQGVKFLRKFKQ 357

  Fly   595 MLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTG 659
            .|||.||:||..|||:.||.||:....||::.|||||:|||||..:|.:.|..|..:||:|||||
 Frog   358 FLNPAQVFDLMNGGPQLGLRLFQKFSNFRILVCGGDGSVGWVLSEIDKLGLQKQCQLGVLPLGTG 422

  Fly   660 NDLARCLRWGGGYEGE-NIPKLMDKFRRASTVMLDRWSIEVTNTP-HSDDMRPKVTLHSNMQKVI 722
            |||||.|.||...:.: .:.::::|..||:|.|||||||....:| ||.   |.:....|.:
 Frog   423 NDLARVLGWGSLCDDDAQLLQILEKLERATTKMLDRWSILTYESPKHSP---PAIREEENGE--- 481

  Fly   723 ELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTN 787
                            .:.|.|..|.|.|:  |.....|:.:.|   ..:.:::.:|
 Frog   482 ----------------AKFQVQISQYADSV--AFHLAKILESDK---HCDVISSAKF-------- 517

  Fly   788 RTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDS-------------- 838
                 ..:|::.|.|:..:...|.|.:...::..:......|:..|:.|.|
 Frog   518 -----LCLSVNDFITEVGKAYARAAENREEADNMARKCSMLNEKLESLVRSLNEESQALLAPPLQ 577

  Fly   839 --HAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGS 901
              |..:|.....|.|..:....|..:   .:.:.|:|:..:....::.:..: :|:|..|.
 Frog   578 SLHPDSALKENSKDVNEKENNMEDMA---KIFKSKEQLMLRANSLKKALKQI-IEQAEKAV---- 634

  Fly   902 NQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPN 966
                  .::||...:....:     ||..:.|..::....|:...|...:|.:|
 Frog   635 ------DEQNKHTQVYSTPM-----LSPIQKESSEEFSKEGESLASRRGTISST----------- 677

  Fly   967 AASSVLQQQQQ--QHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPH 1029
             .||::..:..  ..|.|.:.    .:|..:.||     :||||.:|:||.|.::|:.:|:::|.
 Frog   678 -TSSIILDRPYTFSPLHFSED----AIQFSERCT-----MNNYFGIGLDAKISLEFNNKRDEHPK 732

  Fly  1030 KFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSN 1094
            |.:||.:|.:||....|.|....:.|||.:.:::.|||..:.|   |.|||:|:||||...||.|
 Frog   733 KCSSRTRNMMWYGVLGTKELLQKTYKNLEQRVKLECDGEPISL---PSLQGIAVLNIPSYAGGIN 794

  Fly  1095 LWGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMG 1159
            .||               |..:     |..|.|.||:            |:.:||:.:...:.|.
 Frog   795 FWG---------------GTKE-----DNNFGAPSFD------------DKKLEVVAVFGSIQMA 827

  Fly  1160 QVRTGLRASGRRLAQCS--EVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSEKGR 1222
            ..|. :.....|:|||.  ::.|..::..|:|:|||.|:|.|..:|:.|||:..||     .:.|
 Frog   828 VSRV-INLQHHRIAQCRVVKITILGEEGVPVQVDGEAWVQPPGILKIQHKNRAQML-----TRDR 886

  Fly  1223 GFFNLLCS 1230
            .|.|.|.|
 Frog   887 AFENTLKS 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008	9/68 (13%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	23/73 (32%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	15/52 (29%)
		DAGKc	573..694	CDD:214487	64/121 (53%)
		DAGKa	1003..1194	CDD:214486	60/192 (31%)
dgkk	XP_004916836.1	PH_DGK_type2	68..164	CDD:270093	18/123 (15%)
		C1	148..233	CDD:412127	25/93 (27%)
		C1_DGKeta_rpt2	244..305	CDD:410444	17/60 (28%)
		DAGKc	336..458	CDD:214487	64/121 (53%)
		DAGKa	706..863	CDD:214486	61/197 (31%)
		SAM_superfamily	1087..1150	CDD:472832