DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgk and dgke

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	XP_002937855.1	Gene:	dgke / 100489119	XenbaseID:	XB-GENE-990685	Length:	554	Species:	Xenopus tropicalis

Alignment Length:	900	Identity:	203/900 - (22%)
Similarity:	296/900 - (32%)	Gaps:	410/900 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 MAVAEYLGWDVSE------LRPILQEMMVEIDYDADGTVSLDEWQRGGMTTIPLLVLLGVDSTTL 404
            |.|||..||.::.      |.|:|..:...:             :|.....||
Frog     1 MEVAEEKGWSLAAWTVCAVLLPVLLTLWCSV-------------RRSQRRNIP------------ 40

  Fly   405 KEDGIHVWR-LKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHA----PASCITTYV 464
             ..|.|.|: ...|.||.||::|...::    .|:.|..|.....|.||:.|    |...|..:.
Frog    41 -RTGKHGWQDTDLFGKPTYCSVCGQHIL----HGVYCRSCGLCADEACVRRANRRFPCKEIILWA 100

  Fly   465 KSKKPKCGGDLLHHWVEGN---CYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSVKK--E 524
            :.:.        ||||.||   | ..||.|.::......:....|.||...:|:.|..:..|  :
Frog   101 EGRG--------HHWVRGNVPLC-SLCSVCGQQCGCQPKLCDYRCIWCQRTVHDDCMQNNLKIED 156

  Fly   525 CTLGEYSELIVPPTAICPAVLDRQRSVNQAHKATHFQITPPDELS-------CPLLVFVNPKSGG 582
            |..||:..||:||:.:        .:|.|..|.   :.|..::|:       .||:|..|.:||.
Frog   157 CDFGEFKNLIIPPSYL--------SAVTQLKKG---KTTDYEKLASSMGKQWTPLIVLANTRSGN 210

  Fly   583 RQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLP--RFRVICCGGDGTVGWVLEAMDSIEL 645
            ..|:.:|.:|:.:|||.||:||||..|.:.|.|...||  ..:|:.|||||||||||:|:|.:::
Frog   211 NMGEALLSEFKGLLNPIQVFDLSKVSPFKALQLCTLLPDKSAKVLVCGGDGTVGWVLDAVDEMKI 275

  Fly   646 ----ASQPAIGVIPLGTGNDLARCLRWGGGYEGE-NIPKLMDKFRRASTVMLDRWSIEVTNTPHS 705
                ...|.:.|:|||||||||..|.||.||.|: .:.:::.....|..:.||||.::|||..:|
Frog   276 KGLEGCVPQVAVLPLGTGNDLANTLGWGAGYAGDVPVEQILRNIMDADGIKLDRWKVQVTNKGYS 340

  Fly   706 DDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETE 770
             ..:|||
Frog   341 -LRKPKV---------------------------------------------------------- 346

  Fly   771 METMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETE 835
                                    :||
Frog   347 ------------------------LSM-------------------------------------- 349

  Fly   836 VDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVG 900

Frog   350 ----------------------------------------------------------------- 349

  Fly   901 SNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTP 965

Frog   350 ----------------------------------------------------------------- 349

  Fly   966 NAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHK 1030
                                                   |||||||.||.:.:.||..|||.|..
Frog   350 ---------------------------------------NNYFSVGPDALMALNFHTHREKTPSL 375

  Fly  1031 FNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNL 1095
            |:||:.||..|..|.|.:.....||:|::.:|:..||..:||   |:|:|:.:|||.|..||..|
Frog   376 FSSRLVNKAVYLFYGTKDCLVQECKDLNKKVELELDGERIDL---PNLEGIVVLNIGYWGGGCRL 437

  Fly  1096 WGEHLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQ 1160
            | |.:                    ||:.:..:..:            |.|:||:|:....|..|
Frog   438 W-EGM--------------------GDEPYPLSRHD------------DGLLEVVGVYGSFHCAQ 469

  Fly  1161 VRTGLRASGRRLAQCSEV--IIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPML 1213
            ::..| |:..||.|...|  ::|:.| .|||:|||||.|.|||:.:|||....||
Frog   470 IQVKL-ANPVRLGQAHTVRLLLKSSK-MPMQVDGEPWAQGPCTVTITHKTHALML 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199
		EFh	317..386	CDD:238008	9/45 (20%)
		EF-hand_7	318..382	CDD:290234	9/41 (22%)
		C1	410..459	CDD:237996	16/53 (30%)
		C1_1	477..528	CDD:278556	17/55 (31%)
		DAGKc	573..694	CDD:214487	54/127 (43%)
		DAGKa	1003..1194	CDD:214486	65/192 (34%)
dgke	XP_002937855.1	C1	45..88	CDD:381770	14/46 (30%)
		C1	105..148	CDD:237996	14/43 (33%)
		DAGKc	201..329	CDD:214487	54/127 (43%)
		DAGKa	349..503	CDD:214486	66/398 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000