DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgk and Dgkq

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	XP_038947472.1	Gene:	Dgkq / 100361138	RGDID:	2320722	Length:	973	Species:	Rattus norvegicus

Alignment Length:	1198	Identity:	202/1198 - (16%)
Similarity:	294/1198 - (24%)	Gaps:	731/1198 - (61%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 HVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCIT---TYVKSKKPKC 471
            |.:|....:||.:|:||.:.:.||.  |..|.:|.:..||:|::.....|.:   :.|:.....|
  Rat    55 HSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCLKQVKTPCTSIAPSLVRVPVAHC 117

  Fly   472 GGDL-------------------------------------------------------LHHWVE 481
            .|.|                                                       .|||.|
  Rat   118 FGSLGLYKRKFCVVCRKSLEVPAFRCEVCELHVHPDCVPFACSDCRQCHQDGQHDYDTYHHHWRE 182

  Fly   482 GN--CYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSVKKECTLGEYSELIVPPTAI---- 540
            ||  ...||..|||...:...:.|:.|.||.:..|:.|::::..|||.|....:::||:.:
  Rat   183 GNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSVCSTALTPECTFGRLRSMVLPPSCVRLLS 247

  Fly   541 -------C--------------------------------------------------------- 541
                   |
  Rat   248 RNFSKMHCFRIPETMVLELGDGDDGLDGSAAVGTGREVSAATESTKQTLKIFDGNDSMRKNQFRL 312

  Fly   542 ----------------------------------------------------------------- 541

  Rat   313 VTVSRLARNEEVMEAALRAYYINEDPKDFQLQALPLTLLSGNAQALGKAGTTEEETSKDSGPGDS 377

  Fly   542 ----------------------------------------------------------------- 541

  Rat   378 VPEAWVIRSLPRTQEILKIYPDWLKVGVAYVSIRVNSQSTARSVVQEVLPLFGRQVEDQERFQLI 442

  Fly   542 -----------------PAVLD-----RQRSVNQAHKATHF-----QITP--------------- 564
                             ..:||     ||.||.||.:...:     .:||
  Rat   443 EVLMSSRQVQRTVLVDEEPLLDRLRDIRQTSVRQASQTRFYVAEARAVTPHVSLFVGGLPPGLSP 507

  Fly   565 --------------------------------------------------------------PDE 567
                                                                          ||.
  Rat   508 QDYSNLLHEAMATKAAVVSVSHVYSLQGAVVLDVTCFAEAERLYMLARDTAVHGRPLTALVLPDV 572

  Fly   568 LS-------------------------------------------CPLLVFVNPKSGGRQGDRIL 589
            |:                                           |||||||||||||.:|..:|
  Rat   573 LNLAMSGKRCTEGCRGQRISYEDCQKDLCLGSTKSPQHTKLPPDCCPLLVFVNPKSGGLKGRELL 637

  Fly   590 RKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIE---LASQPAI 651
            ..|:.:|||.||::|:.|||..|..||..:|.|||:.|||||||||||.|::...   ...:|::
  Rat   638 CSFRKLLNPHQVFELTNGGPLPGFHLFSQVPCFRVLVCGGDGTVGWVLAALEETRRHLACPEPSV 702

  Fly   652 GVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHS 716
            .::||||||||.|.||||.||.||:...::.....|..|::|||:|.:
  Rat   703 AILPLGTGNDLGRVLRWGAGYSGEDPFSVLVSVDEADAVLMDRWTILL----------------- 750

  Fly   717 NMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGS 781

  Rat   751 ----------------------------------------------------------------- 750

  Fly   782 STTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADV 846
                                                             ||. |:||
  Rat   751 -------------------------------------------------DAH-EIDS-------- 757

  Fly   847 REKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRN 911

  Rat   758 ----------------------------------------------------------------- 757

  Fly   912 KQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQ 976
            .:||::             |.||
  Rat   758 TENNVV-------------ETEP------------------------------------------ 767

  Fly   977 QQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWY 1041
                       |..||           :|||..:|:||.:.:.||..||:.|.||.||..||..|
  Rat   768 -----------PKIVQ-----------MNNYCGIGIDAELSLDFHQAREEEPGKFTSRFHNKGVY 810

  Fly  1042 FEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIR 1106
            ......:  .:..::||:.|.:..:...::|   |.::|:..:|||....|::|||.. |..|..
  Rat   811 VRVGLQK--ISHSRSLHKEIRLQVEQQEVEL---PSIEGLIFINIPSWGSGADLWGSD-SDSRFE 869

  Fly  1107 KSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRR 1171
            |.                       .:|         |.|:||:|:...:|||||:.||| ||.|
  Rat   870 KP-----------------------RID---------DGLLEVVGVTGVVHMGQVQGGLR-SGIR 901

  Fly  1172 LAQCSEVIIKTKKTFPMQIDGEPWMQMP 1199
            :||.|...:...|..|:|:|||||:|.|
  Rat   902 IAQGSYFRVTLLKATPVQVDGEPWIQAP 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199
		EFh	317..386	CDD:238008
		EF-hand_7	318..382	CDD:290234
		C1	410..459	CDD:237996	15/48 (31%)
		C1_1	477..528	CDD:278556	20/52 (38%)
		DAGKc	573..694	CDD:214487	61/123 (50%)
		DAGKa	1003..1194	CDD:214486	59/190 (31%)
Dgkq	XP_038947472.1	C1_DGKtheta_typeV_rpt1	54..107	CDD:410353	16/53 (30%)
		C1_DGKtheta_typeV_rpt2	111..166	CDD:410354	3/54 (6%)
		C1_DGKtheta_typeV_rpt3	178..240	CDD:410404	21/61 (34%)
		RA1_DAGK-theta	293..389	CDD:340631	0/95 (0%)
		RA2_DAGK-theta	392..486	CDD:340481	8/93 (9%)
		DAGKc	621..745	CDD:214487	61/123 (50%)
		DAGKa	772..924	CDD:214486	60/201 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810