Protein Alignment Dgk and dgki

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: XP_009298312.1
• Gene: dgki / 100331649
• ZFINID: ZDB-GENE-120327-1
• Length: 968
• Species: Danio rerio
• Alignment Length: 868
• Identity: 202/868 - (23%)
• Similarity: 295/868 - (33%)
• Gaps: 390/868 - (44%)

  Fly   399 VDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLC------------CVLCKYTVHERC 451
            ||.:....:|.|:|...:         |...|..||:: .|            |..||..||..|
Zfish   104 VDWSENAVNGDHLWLETN---------CSGELCYLGEE-TCVAKIAKSAPRRKCAACKIVVHTAC 158

  Fly   452 VQHAPA---SCITTYVKSKKPKCGGD---LLHHWVEGNCY-GRCSKCRKRI--KAYHG--ITGLT 505
            ::....   .|..|: :....:|..|   |.||||..... |:|.:|.|..  |.:|.  |..::
Zfish   159 IEELDKINFRCKPTF-REGSSRCLRDQNVLRHHWVHRRRQEGKCRQCGKSFPQKFFHSKEIVAIS 222

  Fly   506 CRWCHMMLHNRCA----SSVKKECTLGEYSELIVPPTAICPAVLDRQRSVNQAHKATH------- 559
            |.||....||:..    ..:::.|:||.::.:||||:.|......:....|...:...
Zfish   223 CSWCKQAFHNKVTCFMLHQIEEPCSLGAHAGVIVPPSWIIKVRKPQSSFKNSTRRKKRTSFKRRA 287

  Fly   560 ------------FQITP-PDELSCPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKE 611
                        |.:.| |..|..|:||||||||||.||.::|:.|.::||||||:|||:|||::
Zfish   288 SKKGTDESKWRPFMLKPLPSPLMKPVLVFVNPKSGGNQGTKLLQMFMWILNPRQVFDLSQGGPRD 352

  Fly   612 GLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGEN 676
            .|.|::.:|..|::.|||||||||:|.|:|.:::..||.:.|:||||||||||.|.|||||..|.
Zfish   353 ALELYRKVPNLRILACGGDGTVGWILSALDELQMNPQPPVAVLPLGTGNDLARTLNWGGGYTDEP 417

  Fly   677 IPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEI 741
            :.|::......|.|.||||:::|
Zfish   418 VSKVLCHVEDGSVVQLDRWNLQV------------------------------------------ 440

  Fly   742 QRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQ 806
                                                                             
Zfish   441 ----------------------------------------------------------------- 440

  Fly   807 QTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHK 871
                                                     |:||                :||:
Zfish   441 -----------------------------------------ERSV----------------VQHE 448

  Fly   872 QQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKD 936
            :..|:
Zfish   449 EGTQK------------------------------------------------------------ 453

  Fly   937 DGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPY 1001
                                                                          :|.
Zfish   454 --------------------------------------------------------------LPL 456

  Fly  1002 NIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCD 1066
            |:.|||||:|.||.:.::||..||.||.|||||.:||::|...|.|:....|.::|.:.:.:|||
Zfish   457 NVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVRVVCD 521

  Fly  1067 GVAL-----DLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSKKLRAGD-KEF 1125
            |..|     :|    ..|.:..||||....|:..||                     ..|| ::|
Zfish   522 GTDLTAKIQEL----KFQCIVFLNIPRYCAGTMPWG---------------------NTGDHRDF 561

  Fly  1126 SATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQI 1190
            ..            |...|..|||||. ....:..::.|  ..|.||.||.||:|.|.||.|:|:
Zfish   562 EP------------QRHDDGCIEVIGF-TMASLAALQVG--GHGDRLHQCREVLITTFKTLPVQV 611

  Fly  1191 DGEPWMQMPCTIKVTHKNQVPML 1213
            ||||....|.|::::.:||..|:
Zfish   612 DGEPCRLAPSTLRISLRNQANMV 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008
		C1_DGKbeta_rpt1	403..468	CDD:410395	16/79 (20%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	17/59 (29%)
		DAGKc	573..694	CDD:214487	66/120 (55%)
		DAGKa	1003..1194	CDD:214486	66/196 (34%)
dgki	XP_009298312.1	C1_DGKiota_rpt1	105..177	CDD:410400	17/82 (21%)
		C1_DGKiota_rpt2	187..260	CDD:410446	24/72 (33%)
		DAGKc	314..435	CDD:214487	66/120 (55%)
		DAGK_acc	458..615	CDD:470579	66/196 (34%)
		ANKYR	<832..967	CDD:440430
		ANK repeat	832..859	CDD:293786
		ANK repeat	861..896	CDD:293786
		ANK repeat	898..928	CDD:293786