Protein Alignment Dgk and dgke

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: NP_001165699.1
• Gene: dgke / 100150463
• ZFINID: ZDB-GENE-090512-7
• Length: 564
• Species: Danio rerio
• Alignment Length: 872
• Identity: 204/872 - (23%)
• Similarity: 291/872 - (33%)
• Gaps: 389/872 - (44%)

  Fly   381 DEWQRGGMTT----IPLLVLL---------GVDSTTLKEDGIHVWRLKH-FSKPAYCNLCLNMLV 431
            :||.....||    :|:|:.|         .:....|.....|.|.... |:||.||.:|...::
Zfish    10 EEWTLFLWTTFAVLVPVLITLWCSFQRPKRKIQLKDLFRKSKHGWHYTDLFNKPTYCCVCCQPIL 74

  Fly   432 GLGKKGLCCVLCKYTVHERCVQHAP--ASCITTYVKSKKPKCGGDLLHHWVEGN--CYGRCSKCR 492
                :|..|..|.....|:|:|.|.  .||.....::   :..|...|.||:||  ....|..|:
Zfish    75 ----QGAFCDCCGICSDEQCIQRADRILSCKEIMTQN---QTDGKFCHQWVKGNVPLASYCGVCK 132

  Fly   493 KRIKAYHGITGLTCRWCHMMLHNRCASSVKKE-CTLGEYSELIVPPTAICPAVLDRQRSVNQAHK 556
            ::......:....|.||...:|:.|.||:..: |.|||:..:|:|     |..|.:...:.:.|
Zfish   133 QQCGTQPKLCDYRCVWCQTTVHDDCLSSLTDDLCDLGEFHSVIIP-----PCYLYQVNKLRRRH- 191

  Fly   557 ATHFQITPPDELS----------CPLLVFVNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKE 611
                    |||.|          .|:||..|.:||...|:.:|.:|:.:|||.||:|||:..|.:
Zfish   192 --------PDEYSKLAAVYGSGWTPVLVLANTRSGNNMGEILLGEFRTLLNPVQVFDLSELPPSK 248

  Fly   612 GLTLFKDLP--RFRVICCGGDGTVGWVLEAMDSIELASQ----PAIGVIPLGTGNDLARCLRWGG 670
            .|.|...||  ..||:.|||||||||||:|:|:::|..|    |.:.::||||||||:..|.||.
Zfish   249 ALQLCTLLPPGSVRVLVCGGDGTVGWVLDAIDTMKLKGQDQFIPLVTILPLGTGNDLSNSLGWGA 313

  Fly   671 GYEGENIP--KLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKS 733
            ||.|| ||  :::.....|..|.:|||.::|.
Zfish   314 GYAGE-IPVEQVLRNVLEAEVVKMDRWKVQVA--------------------------------- 344

  Fly   734 LMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMS 798
                                                                             
Zfish   345 ----------------------------------------------------------------- 344

  Fly   799 TFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSL 863
                                                                             
Zfish   345 ----------------------------------------------------------------- 344

  Fly   864 ETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLS 928
                                                                             
Zfish   345 ----------------------------------------------------------------- 344

  Fly   929 DHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQS 993
                              |.||..                                 :|| ||.|
Zfish   345 ------------------SKGNYF---------------------------------RKP-KVLS 357

  Fly   994 DKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSETFAASCKNLH 1058
                      :|||||||.||.:.:.||:.|||.|..|:||:.||..||.|.|.:.....||:|.
Zfish   358 ----------MNNYFSVGPDALMALNFHVHREKTPSFFSSRIINKAVYFLYGTKDCLVQECKDLD 412

  Fly  1059 ESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSKKLRAGDK 1123
            :.||:..||..:.|   |:|:|:.:.||....||..|| |.:                    ||:
Zfish   413 KRIELELDGEQVTL---PNLEGIIVCNIGNWGGGCRLW-EGM--------------------GDE 453

  Fly  1124 EFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEV--IIKTKKTF 1186
            .:..|   .||         |.|:||:|:....|..|::..| |:..||.|...|  ::|:.: .
Zfish   454 PYPPT---RVD---------DGLLEVVGVYGSFHCAQIQVKL-ANPVRLGQAHTVRLVLKSSR-M 504

  Fly  1187 PMQIDGEPWMQMPCTIKVTHKNQVPML 1213
            |||:|||||.|.||||.:|||.|..||
Zfish   505 PMQVDGEPWAQGPCTITITHKTQALML 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008	2/4 (50%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	18/67 (27%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	15/53 (28%)
		DAGKc	573..694	CDD:214487	58/128 (45%)
		DAGKa	1003..1194	CDD:214486	66/192 (34%)
dgke	NP_001165699.1	C1_DGKepsilon_typeIII_rpt1	49..102	CDD:410351	17/56 (30%)
		C1_DGKepsilon_typeIII_rpt2	115..178	CDD:410403	20/67 (30%)
		DAGKc	210..338	CDD:214487	58/128 (45%)
		DAGK_acc	358..512	CDD:470579	66/191 (35%)