Protein Alignment Dgk and dgka

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: XP_012813262.1
• Gene: dgka / 100124931
• XenbaseID: XB-GENE-985269
• Length: 744
• Species: Xenopus tropicalis
• Alignment Length: 1243
• Identity: 388/1243 - (31%)
• Similarity: 522/1243 - (41%)
• Gaps: 530/1243 - (42%)

  Fly     9 KWDKLSPREFLQLQELASYSTRKLQDVLREFSSPSAASTPKCIPDGDIDFDGFRRFLDAFLDC-E 72
            :|..|||.:|.|||:...|||:|::||.:||.. ...|.|..:.| .|||:.|:.||..:|:. :
 Frog     7 EWAILSPEDFTQLQKYIDYSTKKVKDVQQEFYG-DGTSCPHLVED-TIDFEAFKSFLKTYLEVDD 69

  Fly    73 APLDLAKHLFVSFLKPNVTQAQLHGRALNQMAAISSTAACAPVTSHTKGSIPNINSIAELMPQCS 137
            .|.:|.:.||:||      ||                   .|:.|...|.
 Frog    70 IPNNLCERLFMSF------QA-------------------TPIESKKSGE--------------- 94

  Fly   138 GGGGGIGGTGGVAGAEGHAQARSSFVDKIHGITDKLHHSLGGHLSHDPSKTGSVHPMLTVTPSPL 202
                                      |:..||
 Frog    95 --------------------------DETEGI--------------------------------- 100

  Fly   203 ASGPSMFQASNPARRSVDSSPSHSATNHSQMSRNSSKKSSNSVNCKIDAVSRILPAIGRHCPGSL 267
                                                                             
 Frog   101 ----------------------------------------------------------------- 100

  Fly   268 ESGSAQAEKRADIKLLARKLSHFDPLTLKVPLKDVVCYLSLLEAGRPEDKLEFMFRLYDTDSNGV 332
             .||.                       ::.|.||.||.||||:|..||||.|.|:|||.||||:
 Frog   101 -KGSG-----------------------RISLNDVSCYFSLLESGTAEDKLAFTFKLYDKDSNGL 141

  Fly   333 LDTAEMDAIVNQMMAVAEYLGWDVSELRPILQEMMVEIDYDADGTVSLDEWQRGGMTTIPLLVLL 397
            ||::|:|.|:.|||.|||||.||::||:|:|:|||.::|||.:|.||.:||.:||:||:||||||
 Frog   142 LDSSEVDRIITQMMRVAEYLDWDITELKPMLEEMMRQVDYDGNGIVSYEEWVKGGLTTVPLLVLL 206

  Fly   398 GVDSTTLKEDGIHVWRLKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITT 462
            |:: ..:|:||.|:||||||::|.|||:|..:|.|:.|:||||..||:||||||.:.||.|||:|
 Frog   207 GME-VNIKDDGQHLWRLKHFNRPVYCNVCEALLFGVRKQGLCCTFCKFTVHERCARKAPNSCIST 270

  Fly   463 YVKSKKPKCGGDLLHHWVEGNC-YGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRCASSVKKECT 526
            |.||:|.  ..:..|.|:.|.| ..:|.||:|:||::..:||..|.|||..:|:.||||  ..|.
 Frog   271 YAKSRKD--FSEQAHVWMRGGCEASKCDKCQKKIKSFQSLTGQRCVWCHTKVHDECASS--PLCD 331

  Fly   527 LGEYSELIVPPTAICPAVLDRQRS----VNQAHKATHFQITPPDEL--------SCPLLVFVNPK 579
            .|...:.|:||..|.|.:|:||.|    :..:.:|:....||..::        :.|||||||||
 Frog   332 GGILKDHILPPACIYPVILERQNSQKNLLASSEEASQTFSTPEGQVLRIAPLPGTHPLLVFVNPK 396

  Fly   580 SGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIE 644
            |||:||:|:||||||:||||||::|.||||..||..|:|:|.:|::.|||||||||:|:|:|...
 Frog   397 SGGKQGERVLRKFQYLLNPRQVHNLIKGGPSPGLNFFRDVPEYRILVCGGDGTVGWILDAIDKAN 461

  Fly   645 LASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMR 709
            |..:|.:.|:||||||||||||.|||||:|||:.|.:....::..:.:|||:|||
 Frog   462 LPYRPPVAVLPLGTGNDLARCLSWGGGYDGENLMKFLKDIEKSVPIKMDRWNIEV---------- 516

  Fly   710 PKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETM 774
                                                                             
 Frog   517 ----------------------------------------------------------------- 516

  Fly   775 ATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSH 839
                                                                             
 Frog   517 ----------------------------------------------------------------- 516

  Fly   840 AAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQS 904
                                                                             
 Frog   517 ----------------------------------------------------------------- 516

  Fly   905 DNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAAS 969
                                                           ||..|
 Frog   517 -----------------------------------------------IPENP------------- 521

  Fly   970 SVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSR 1034
                                   .:|...|||.|||||||:||||:|..:||..|||.|.|||||
 Frog   522 -----------------------DEKGDPVPYEIINNYFSIGVDASIAHRFHNMREKYPEKFNSR 563

  Fly  1035 MKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGE- 1098
            |||||||||:|||||..::||.|.|.|.|.|.|..|.|:: ..|:|:|::|||..|||||||||
 Frog   564 MKNKLWYFEFATSETVFSTCKKLKEVITIECCGSPLKLSS-LSLEGIAVINIPSMHGGSNLWGET 627

  Fly  1099 --HLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVD-------LSVAIQDFGDRLIEVIGLEN 1154
              |..:.|                     :|:..|:.:       |...:||..|:.:||:|||.
 Frog   628 KKHWGEPR---------------------NASCHNAPEAITDPDALKSCVQDLSDKRLEVVGLEG 671

  Fly  1155 CLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSE 1219
            .:.|||:.|||:::|:|||.|||:.|:|.|..|||||||||||.|||||:|||||.|||.|| :.
 Frog   672 AIEMGQIYTGLKSAGKRLATCSELTIRTTKPLPMQIDGEPWMQPPCTIKITHKNQAPMLRAP-AP 735

  Fly  1220 KGRGFFNL 1227
            :...||:|
 Frog   736 RSSSFFSL 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196	35/108 (32%)
		EFh	317..386	CDD:238008	41/68 (60%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	39/64 (61%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	22/51 (43%)
		DAGKc	573..694	CDD:214487	72/120 (60%)
		DAGKa	1003..1194	CDD:214486	97/200 (49%)
dgka	XP_012813262.1	DAG_kinase_N	7..122	CDD:464196	51/304 (17%)
		EFh	126..195	CDD:238008	41/68 (60%)
		C1_DGK_typeI_rpt1	213..274	CDD:410349	37/60 (62%)
		C1_DGKalpha_rpt2	283..342	CDD:410440	24/60 (40%)
		DAGKc	390..511	CDD:214487	72/120 (60%)
		DAGKa	532..711	CDD:214486	97/200 (49%)