DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dgk and prkcba

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	NP_957323.1	Gene:	prkcba / 100006675	ZFINID:	ZDB-GENE-040426-1354	Length:	668	Species:	Danio rerio

Alignment Length:	244	Identity:	59/244 - (24%)
Similarity:	98/244 - (40%)	Gaps:	50/244 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 DADGTVSLDEWQRGGMTTIPLLVLLGVDSTTLKEDGIHVWR-----LKHFSKPAYCNLCLNMLVG 432
            |:||......:.|.|               .|::..:|..:     .:.|.:|.:|:.|.:.:.|
Zfish     6 DSDGKEGARGFARQG---------------ALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWG 55

  Fly   433 LGKKGLCCVLCKYTVHERCVQHAPASCITTYVKSKKPKCGGDLLHHWVEGNCYGR---CSKCRKR 494
            .||:|..|.:|.:.||:||.:....||..:   .|.|.......:|..:.:.|..   |..|...
Zfish    56 FGKQGFQCQVCCFVVHKRCHEFVHFSCPGS---DKGPASDDPRKYHSFKVHTYTSPTFCDHCGSL 117

  Fly   495 IKAYHGI--TGLTCRWCHMMLHNRCASSVKKECTLGEYSE---LIVPPTAICPAVLDRQRSVNQA 554
            :   :|:  .|:.|..|.|.:|.||...|...|.. :::|   .:....:|...||  ..||.:|
Zfish   118 L---YGLIHQGMRCLNCLMNIHKRCFKHVPSLCGT-DHTEKRGRLHFSASITGNVL--SVSVKEA 176

  Fly   555 HKATHFQITP--PDELSCP---LLVFVNPKSGGRQGDRILRKFQYMLNP 598
            .     .:.|  |..||.|   |.:..:|||..:|..:.::.   .|||
Zfish   177 R-----NLVPMDPSGLSDPYVKLKLIPDPKSESKQKTKTIKG---CLNP 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199
		EFh	317..386	CDD:238008	3/12 (25%)
		EF-hand_7	318..382	CDD:290234	3/8 (38%)
		C1	410..459	CDD:237996	15/53 (28%)
		C1_1	477..528	CDD:278556	14/55 (25%)
		DAGKc	573..694	CDD:214487	7/26 (27%)
		DAGKa	1003..1194	CDD:214486
prkcba	NP_957323.1	C1_1	33..85	CDD:278556	16/51 (31%)
		C1_1	98..148	CDD:278556	13/52 (25%)
		C2_PKC_alpha_gamma	155..285	CDD:175992	19/73 (26%)
		PKc_like	337..659	CDD:304357
		S_TKc	338..596	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0696
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900