DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phr and Cry2

DIOPT Version :9

Sequence 1:	NP_523653.2	Gene:	phr / 35735	FlyBaseID:	FBgn0003082	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_596896.2	Gene:	Cry2 / 170917	RGDID:	620935	Length:	594	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	96/497 - (19%)
Similarity:	165/497 - (33%)	Gaps:	173/497 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 VKESSLG----GVVYWMSRDGRVQDNWALLFAQRLALKLELPLTVVFCLVPKFLNAT---IRHYK 166
            |...|:|    ..|:|..:..|:.||.|||.|.|.|..:.    .|:.|.|.|..::   |..::
  Rat    11 VPAQSMGADGASSVHWFRKGLRLHDNPALLAAVRGARCVR----CVYILDPWFAASSSVGINRWR 71

  Fly   167 FMMGGLQEVEQQCRALDIPFHLLMGSAVEKLPQFVKSKDIGAVVCDFAPLRLPRQWVEDVGK--- 228
            |::..|::::...|.|:....::.|...:..|:..|...:..:..::..        |..||
  Rat    72 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDS--------EPFGKERD 128

  Fly   229 ------ALPKSVPLVQVDAHNVVPLWVASDK-------------QEYAARTIRNKINSKLGEYLS 274
                  |....|.:|..::|.:..|    |:             :.:.|...|.::..|
  Rat   129 AAIMKMAKEAGVEVVTENSHTLYDL----DRIIELNGQKPPLTYKRFQALISRMELPKK------ 183

  Fly   275 VFPPV--VRHPHGTGCKNVNTVDWSAAYASLQCDME-------VDEVQWAKPGYKAACQQ----- 325
               ||  |...|...|:           |.:|.:.:       ::|:.:...|...|..|
  Rat   184 ---PVGAVSSQHMENCR-----------AEIQENHDDTYGVPSLEELGFPTEGLGPAVWQGGETE 234

  Fly   326 ----LYEFCSRRLRHFNDKRNDPTADAL----SGLSPWLHFGHISAQRCALEVQRFRGQHKASAD 382
                |.:...|:....|.:|....|::|    :||||:|.||.:|   |.|
  Rat   235 ALARLDKHLERKAWVANYERPRMNANSLLASPTGLSPYLRFGCLS---CRL-------------- 282

  Fly   383 AFCEEAIVRRELADNFCFYNEHYDSLKGLSSWAYQTLDAHRKDKRDPCYSLEELEKSLTYDDLWN 447
                             ||              |:..|.:||.||:....| .|...|.:.:.:.
  Rat   283 -----------------FY--------------YRLWDLYRKVKRNSTPPL-SLFGQLLWREFFY 315

  Fly   448 SAQLQLVREGKMHGFLRMYWAKKI---LEWTATPEHALEYAILLNDKYSLDGRDPNGYVGCMW-- 507
            :|.....|..:|.|       ..|   :.|...||...::|              .|..|..|
  Rat   316 TAATNNPRFDRMEG-------NPICIQIPWDRNPEALAKWA--------------EGKTGFPWID 359

  Fly   508 -------SIGGVHDMGWKERAIF---GKVRYMNYQGCRRKFD 539
                   ..|.:|.:.....|.|   |.: :::::...|.||
  Rat   360 AIMTQLRQEGWIHHLARHAVACFLTRGDL-WVSWESGVRVFD 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phr	NP_523653.2	phr2	93..547	CDD:129679	96/497 (19%)
phr	NP_523653.2	DNA_photolyase	117..278	CDD:279247	35/185 (19%)
Cry2	NP_596896.2	PhrB	21..509	CDD:223492	93/487 (19%)
		DNA_photolyase	23..171	CDD:279247	32/163 (20%)
		FAD_binding_7	231..504	CDD:281440	47/241 (20%)
		Required for inhibition of CLOCK-ARNTL-mediated transcription. /evidence=ECO:0000250\|UniProtKB:Q9R194	389..488		3/12 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0415
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810