DRSC/TRiP Functional Genomics Resources

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Protein Alignment phr and CRY2

DIOPT Version :10

Sequence 1:NP_523653.2 Gene:phr / 35735 FlyBaseID:FBgn0003082 Length:555 Species:Drosophila melanogaster
Sequence 2:NP_066940.3 Gene:CRY2 / 1408 HGNCID:2385 Length:593 Species:Homo sapiens


Alignment Length:417 Identity:82/417 - (19%)
Similarity:143/417 - (34%) Gaps:135/417 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 VYWMSRDGRVQDNWALLFAQRLALKLELPLTVVFCLVPKFLNAT---IRHYKFMMGGLQEVEQQC 179
            |:|..:..|:.||.|||.|.|.|..:.    .|:.|.|.|..::   |..::|::..|::::...
Human    25 VHWFRKGLRLHDNPALLAAVRGARCVR----CVYILDPWFAASSSVGINRWRFLLQSLEDLDTSL 85

  Fly   180 RALDIPFHLLMGSAVEKLPQFVKSKDIGAVVCDFAPLRLPRQWVEDVGK---------ALPKSVP 235
            |.|:....::.|...:..|:..|...:..:..::..        |..||         |....|.
Human    86 RKLNSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDS--------EPFGKERDAAIMKMAKEAGVE 142

  Fly   236 LVQVDAHNVVPLWVASDKQEYAARTIRNKINSKLGEYLSVFPPVV--------------RHPHGT 286
            :|..::|.:..|                   .::.|.....||:.              :.|.|.
Human   143 VVTENSHTLYDL-------------------DRIIELNGQKPPLTYKRFQAIISRMELPKKPVGL 188

  Fly   287 GCKNVNTVDWSAAYASLQCDME-------VDEVQWAKPGYKAACQQ---------LYEFCSRRLR 335
                |.:....:..|.:|.:.:       ::|:.:...|...|..|         |.:...|:..
Human   189 ----VTSQQMESCRAEIQENHDETYGVPSLEELGFPTEGLGPAVWQGGETEALARLDKHLERKAW 249

  Fly   336 HFNDKRNDPTADAL----SGLSPWLHFGHISAQRCALEVQRFRGQHKASADAFCEEAIVRR---- 392
            ..|.:|....|::|    :||||:|.||.:|   |.|...|....:|.          |:|    
Human   250 VANYERPRMNANSLLASPTGLSPYLRFGCLS---CRLFYYRLWDLYKK----------VKRNSTP 301

  Fly   393 ------ELADNFCFY-----NEHYDSLKG---------------LSSWA-----YQTLDAHRKDK 426
                  :|.....||     |..:|.::|               |:.||     :..:||.....
Human   302 PLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQL 366

  Fly   427 RDPCYSLEELEKS-----LTYDDLWNS 448
            |...: :..|.:.     ||..|||.|
Human   367 RQEGW-IHHLARHAVACFLTRGDLWVS 392

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
phrNP_523653.2 phr2 93..547 CDD:129679 82/417 (20%)
CRY2NP_066940.3 PhrB 21..506 CDD:440184 82/417 (20%)
Required for inhibition of CLOCK-BMAL1-mediated transcription. /evidence=ECO:0000250|UniProtKB:Q9R194 390..489 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..593
Blue background indicates that the domain is not in the aligned region.

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