Protein Alignment phr and CRY1

DIOPT Version :10

• Sequence 1: NP_523653.2
• Gene: phr / 35735
• FlyBaseID: FBgn0003082
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_001400387.1
• Gene: CRY1 / 1407
• HGNCID: 2384
• Length: 606
• Species: Homo sapiens
• Alignment Length: 403
• Identity: 78/403 - (19%)
• Similarity: 138/403 - (34%)
• Gaps: 107/403 - (26%)

  Fly   118 VYWMSRDGRVQDNWALLFAQRLALKLELPLTVVFCLVPKFL---NATIRHYKFMMGGLQEVEQQC 179
            |:|..:..|:.||.||    :..::....:..|:.|.|.|.   |..|..::|::..|::::...
Human     6 VHWFRKGLRLHDNPAL----KECIQGADTIRCVYILDPWFAGSSNVGINRWRFLLQCLEDLDANL 66

  Fly   180 RALDIPFHLLMGSAVEKLPQFVKSKDIGAVVCDFAPLRLPRQWVEDVGKALPKSVPLVQVDA--- 241
            |.|:....::.|...:..|:..|..:|..:..::..        |..||....::..:..:|
Human    67 RKLNSRLFVIRGQPADVFPRLFKEWNITKLSIEYDS--------EPFGKERDAAIKKLATEAGVE 123

  Fly   242 ------HNVVPLWVASDK-------------------------QEYAARTIRNKINSKLGEYLSV 275
                  |.:..|    ||                         .|....||.:::..|....||
Human   124 VIVRISHTLYDL----DKIIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLS- 183

  Fly   276 FPPVVRHPHGTGCKNVNTVDWSAAYASLQCDMEVDEVQWAKPGYKA-ACQQLYEFCSRRLRHFND 339
                ..|....|..::..:.:.....|        ...|  ||.:. |..:|.....|:....|.
Human   184 ----DDHDEKYGVPSLEELGFDTDGLS--------SAVW--PGGETEALTRLERHLERKAWVANF 234

  Fly   340 KRNDPTADAL----SGLSPWLHFGHISAQRCALEVQRFRGQHK-----ASADAFCEEAIVRRELA 395
            :|....|::|    :||||:|.||.:|   |.|...:....:|     :|........::.||..
Human   235 ERPRMNANSLLASPTGLSPYLRFGCLS---CRLFYFKLTDLYKKVKKNSSPPLSLYGQLLWREFF 296

  Fly   396 DNFCFYNEHYDSLKG---------------LSSWA-----YQTLDAHRKDKRDPCYSLEELEKS- 439
            ......|..:|.::|               |:.||     :..:||.....|...: :..|.:.
Human   297 YTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGW-IHHLARHA 360

  Fly   440 ----LTYDDLWNS 448
                ||..|||.|
Human   361 VACFLTRGDLWIS 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phr	NP_523653.2	phr2	93..547	CDD:129679	78/403 (19%)
CRY1	NP_001400387.1	PhrB	5..487	CDD:440184	78/403 (19%)
		LIR 1. /evidence=ECO:0000250|UniProtKB:P97784	50..54		0/3 (0%)
		LIR 2. /evidence=ECO:0000250|UniProtKB:P97784	82..87		1/4 (25%)
		LIR 3. /evidence=ECO:0000250|UniProtKB:P97784	151..156		0/4 (0%)
		LIR 4. /evidence=ECO:0000250|UniProtKB:P97784	255..260		3/4 (75%)
		LIR 5. /evidence=ECO:0000250|UniProtKB:P97784	271..276		1/4 (25%)
		LIR 6. /evidence=ECO:0000250|UniProtKB:P97784	285..290		0/4 (0%)
		LIR 7. /evidence=ECO:0000250|UniProtKB:P97784	335..339		0/3 (0%)
		Required for inhibition of CLOCK-BMAL1-mediated transcription. /evidence=ECO:0000250|UniProtKB:P97784	371..470		2/3 (67%)
		LIR 8. /evidence=ECO:0000250|UniProtKB:P97784	379..384
		LIR 9. /evidence=ECO:0000250|UniProtKB:P97784	395..400
		LIR 10. /evidence=ECO:0000250|UniProtKB:P97784	411..416
		LIR 11. /evidence=ECO:0000250|UniProtKB:P97784	430..435
		Interaction with TIMELESS. /evidence=ECO:0000250|UniProtKB:P97784	471..493
		LIR 12. /evidence=ECO:0000250|UniProtKB:P97784	486..491
		LIR 13. /evidence=ECO:0000250|UniProtKB:P97784	492..497