DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puml and ECM18

DIOPT Version :9

Sequence 1:	NP_001286169.1	Gene:	puml / 35733	FlyBaseID:	FBgn0033226	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_010410.3	Gene:	ECM18 / 851703	SGDID:	S000002532	Length:	453	Species:	Saccharomyces cerevisiae

Alignment Length:	425	Identity:	77/425 - (18%)
Similarity:	152/425 - (35%)	Gaps:	139/425 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 RNNRFFLWKWLCNWTSSSPTMLRAVEKKILSYVKLPYRGFFVDIGPAVGEADKI------WTI-S 105
            :.:.|.||....|....:...|..::::|:..|.:          ..:.:.||:      |.. :
Yeast    65 KKSGFKLWSSHLNNPHKTYMRLEELQRRIMEEVHV----------EGIKKNDKLFNEINQWHFQN 119

  Fly   106 MNTESKEVPLVLLHGLGAGIALWVMNLDAFAKG-RPVYAMDILGFGRSS---------RPLFAKD 160
            .||.:...|.:|:||..|....:..|....:|. |.:|::|:...|.||         .||....
Yeast   120 ENTSTVRTPTLLIHGYAASSMSFFRNYPGLSKHIRNLYSIDMPASGLSSVPSLEINTTTPLPLDI 184

  Fly   161 ALVCEKQF----------------------VKSVEEWRREMNINDMILLGHSMGGFIASSYALSH 203
            ..:.|.:|                      :..:|:||.:..:..|.::|||.||:::..||:.:
Yeast   185 KFIGENKFKVPYTINANHNKFVIQMYEDFYLDRIEQWRIDNKLGKMNVVGHSFGGYLSFKYAVKY 249

  Fly   204 PERVKHLILADPWGFPEKPSDSTNGKTIPLWVRAIARVLTPLNPLWALRAAGPFGQWVVQKTRPD 268
            |..|..|.|..|.|. |:...|.|..             ...|.|:.:....|..::..::
Yeast   250 PNSVNKLCLVSPLGV-ERNIWSVNNN-------------FHSNTLYTIDFKNPNSKFYSKR---- 296

  Fly   269 IMRKFQSTIEEDINLLPQYI-----HQCNAQNPSGES-------AFHTMMQSFGW---------- 311
                         |::|:|:     |......|.|..       |.::.:.|..:
Yeast   297 -------------NMIPKYLFEQQFHILRMMGPLGAKLCWNYIMAAYSRVPSLAYKEYIFELFYG 348

  Fly   312 ---------------------AKHPMIHRIK--DVRSDIPITFIYGSRSWIDSSSG-------EK 346
                                 ||.|::..::  :|:.   :..:||...|::..:|       ..
Yeast   349 KGGIPEVTTDIFKALFSRCILAKDPLMDSLQYLNVKK---LLIVYGQYDWMNKKAGMFMVKELNN 410

  Fly   347 IKS-QRGSNMVDIKIVTGAGHHVYADKPDVFNRYV 380
            :|: ..|::.::|   ..:||:::.|.|:.||:.:
Yeast   411 LKNCLEGASYLEI---PSSGHNLFLDNPESFNQSI 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puml	NP_001286169.1	MhpC	114..382	CDD:223669	65/352 (18%)
puml	NP_001286169.1	Abhydrolase_5	114..>226	CDD:289465	35/143 (24%)
ECM18	NP_010410.3	PLN02894	<112..442	CDD:215484	68/366 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I2109
eggNOG	1	0.900	-	-		E2759_KOG4409
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2279
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001034
OrthoInspector	1	1.000	-	-		otm46957
orthoMCL	1	0.900	-	-		OOG6_101137
Panther	1	1.100	-	-	O	PTHR42886
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X562
TreeFam	1	0.960	-	-
	10	9.720