DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puml and Abhd5

DIOPT Version :9

Sequence 1:	NP_001286169.1	Gene:	puml / 35733	FlyBaseID:	FBgn0033226	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_080455.1	Gene:	Abhd5 / 67469	MGIID:	1914719	Length:	351	Species:	Mus musculus

Alignment Length:	359	Identity:	166/359 - (46%)
Similarity:	228/359 - (63%)	Gaps:	21/359 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ALGSESKSSMDLEDPRNNRFFLWKWLCNWTSSSPTMLRAVEKKIL-----SYVKLPYRGFFVDIG 92
            |:.:|.:  :|..|......:|..||..|..:|.:.|:..|:|:|     :|.|.|.|
Mouse     3 AMAAEEE--VDSADAGGGSGWLTGWLPTWCPTSTSHLKEAEEKMLKCVPCTYKKEPVR------- 58

  Fly    93 PAVGEADKIWTI--SMNTESKEVPLVLLHGLGAGIALWVMNLDAFAKGRPVYAMDILGFGRSSRP 155
              :...::|||:  |.|..|| .|||||||.|.|:.||.:|.:..:..|||||.|:|||||||||
Mouse    59 --ISNGNRIWTLMFSHNISSK-TPLVLLHGFGGGLGLWALNFEDLSTDRPVYAFDLLGFGRSSRP 120

  Fly   156 LFAKDALVCEKQFVKSVEEWRREMNINDMILLGHSMGGFIASSYALSHPERVKHLILADPWGFPE 220
            .|..||...|.|||:|:||||..:.::.||||||::|||:|::|:|.:|.||.||||.:||||||
Mouse   121 RFDSDAEEVENQFVESIEEWRCALRLDKMILLGHNLGGFLAAAYSLKYPSRVSHLILVEPWGFPE 185

  Fly   221 KPSDSTNGKTIPLWVRAIARVLTPLNPLWALRAAGPFGQWVVQKTRPDIMRKFQSTIEEDINLLP 285
            :|..:...:.||:|:||:...|||.|||..||.|||||..:||:.|||..||:.|..|:|  .:.
Mouse   186 RPDLADQERPIPVWIRALGAALTPFNPLAGLRIAGPFGLSLVQRLRPDFKRKYSSMFEDD--TVT 248

  Fly   286 QYIHQCNAQNPSGESAFHTMMQSFGWAKHPMIHRIKDVRSDIPITFIYGSRSWIDSSSGEKIKSQ 350
            :||:.||.|.||||:||..|...:||||.||:.||..:..|||::.|:|:||.||.:||..|:|.
Mouse   249 EYIYHCNVQTPSGETAFKNMTIPYGWAKRPMLQRIGGLHPDIPVSVIFGARSCIDGNSGTSIQSL 313

  Fly   351 RGSNMVDIKIVTGAGHHVYADKPDVFNRYVNETC 384
            |..:.|....:.||||:||||:|:.||:.|.|.|
Mouse   314 RPKSYVKTIAILGAGHYVYADQPEEFNQKVKEIC 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puml	NP_001286169.1	MhpC	114..382	CDD:223669	140/267 (52%)
puml	NP_001286169.1	Abhydrolase_5	114..>226	CDD:289465	65/111 (59%)
Abhd5	NP_080455.1	PLN02894	3..347	CDD:215484	165/357 (46%)
Abhd5	NP_080455.1	HXXXXD motif	329..334		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837284
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4409
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	344	1.000	Inparanoid score	I2311
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57834
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001034
OrthoInspector	1	1.000	-	-		otm44253
orthoMCL	1	0.900	-	-		OOG6_101137
Panther	1	1.100	-	-	O	PTHR42886
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R207
SonicParanoid	1	1.000	-	-		X562
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790