DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puml and Ephx2

DIOPT Version :9

Sequence 1:	NP_001286169.1	Gene:	puml / 35733	FlyBaseID:	FBgn0033226	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_075225.1	Gene:	Ephx2 / 65030	RGDID:	620732	Length:	554	Species:	Rattus norvegicus

Alignment Length:	244	Identity:	54/244 - (22%)
Similarity:	83/244 - (34%)	Gaps:	97/244 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 DIGPAVGEADKIWTISMNTESKEVPL-------------------VLLH----GLGAGIAL---- 127
            |...|:.|.:|:    ..|:..|.||                   :.||    |.|..|.|
  Rat   205 DTASALRELEKV----TGTQFPEAPLPVPCSPNDVSHGYVTVKPGIRLHFVEMGSGPAICLCHGF 265

  Fly   128 ------WVMNLDAFAK-GRPVYAMDILGFGRSSRPLFAKD---ALVCEKQFVKSVEEWRREMNIN 182
                  |...:.|.|: |..|.|:|:.|:|.||.|...::   .|:||:...     :..::.|.
  Rat   266 PESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSPPEIEEYAMELLCEEMVT-----FLNKLGIP 325

  Fly   183 DMILLGHSMGGFIASSYALSHPERVKHLILADPWGFPEKPSDSTNGKTIPLWVRAIARVLTPLNP 247
            ..:.:||...|.:..:.||.||||                            |||:|.:.|||.|
  Rat   326 QAVFIGHDWAGVLVWNMALFHPER----------------------------VRAVASLNTPLMP 362

  Fly   248 LWALRAAGPFGQWVVQKTRPDIMRKFQSTIEEDINLLPQYIHQCNAQNP 296
                             ..|::      :..|.|..:|.:.:|...|.|
  Rat   363 -----------------PNPEV------SPMEVIRSIPVFNYQLYFQEP 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puml	NP_001286169.1	MhpC	114..382	CDD:223669	48/220 (22%)
puml	NP_001286169.1	Abhydrolase_5	114..>226	CDD:289465	33/148 (22%)
Ephx2	NP_075225.1	Phosphatase	1..224		5/22 (23%)
		HAD-SF-IA-v3	5..203	CDD:273662
		Phosphate binding. /evidence=ECO:0000250\|UniProtKB:P34913	123..124
		HAD_like	<142..205	CDD:304363	54/244 (22%)
		Epoxide hydrolase	233..554		46/212 (22%)
		Abhydrolase	239..>379	CDD:304388	43/195 (22%)
		Abhydrolase_1	257..530	CDD:278959	42/188 (22%)
		Microbody targeting signal. /evidence=ECO:0000255	552..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910