DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puml and Abhd8

DIOPT Version :9

Sequence 1:	NP_001286169.1	Gene:	puml / 35733	FlyBaseID:	FBgn0033226	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_071864.2	Gene:	Abhd8 / 64296	MGIID:	1918946	Length:	439	Species:	Mus musculus

Alignment Length:	363	Identity:	81/363 - (22%)
Similarity:	127/363 - (34%)	Gaps:	108/363 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 TISMNTESK---------EVPLVLLHGLGAGIALWVMNLDAFAK-GRPVYAMDILGFGRSSRPLF 157
            ||.::.|.:         :|.|..:||:|..:|:|...||.|.: |..|.|.|:.|.|.||.|..
Mouse   149 TIHIDCEQRITSCKGAQADVVLFFIHGVGGSLAIWKEQLDFFVRLGYEVVAPDLAGHGASSAPQV 213

  Fly   158 AKDALVCEKQFVKSVEEWR-------REMNINDMILLGHSMGGFIASSYALSHPERVKHLILADP 215
            |     ....|....|:.|       ::.|    :|:|||.|....:..|..:|:.|..:|:.:.
Mouse   214 A-----AAYTFYALAEDMRAIFTRYAKKRN----VLIGHSYGVSFCTFLAHEYPDLVHKVIMING 269

  Fly   216 WGFPE--KPS--DSTNGKTIPLWVRAIARVLTPLNP--LWALRAAGPFGQWVVQKTRPDIMRKFQ 274
            .| |.  :||  ...|..|.         ||..|:|  .|:...||...|...:|
Mouse   270 GG-PTALEPSLCSIFNMPTC---------VLHCLSPCLAWSFLKAGFARQGAKEK---------- 314

  Fly   275 STIEEDINLLPQYIHQCNAQNPSGESAFHTMMQSFGWAKHPMIHRIKDVRSDIPITFIYGSRSWI 339
                       |.:.:.||.|.| ......||....|   |....:......:|:..::|...
Mouse   315 -----------QLLKEGNAFNVS-SFVLRAMMSGQYW---PEGDEVYHAELTVPVLLVHGMHD-- 362

  Fly   340 DSSSGEKIKSQRGSNMVDI------KIVTGAGHHVYADKPDVFNRYVNETCDMYKVAGGKLITPL 398
                 :.:..:....|.:|      |::....|.|..:.|:..|..::|..
Mouse   363 -----KFVPVEEDQRMAEILLLAFLKLIEEGSHMVMLECPETVNTLLHEFL-------------- 408

  Fly   399 QLIRESTESDEEREPSLSTAKTVEVQPE---VQPVPQP 433
                 ..|.:.|.||.|      |.:|:   :||.|.|
Mouse   409 -----LWEPEPEAEPKL------EPKPKPQLLQPEPAP 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puml	NP_001286169.1	MhpC	114..382	CDD:223669	65/287 (23%)
puml	NP_001286169.1	Abhydrolase_5	114..>226	CDD:289465	36/123 (29%)
Abhd8	NP_071864.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..75
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..148
		MhpC	149..408	CDD:223669	70/309 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..439		10/27 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910