DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puml and ABHD5

DIOPT Version :9

Sequence 1:	NP_001286169.1	Gene:	puml / 35733	FlyBaseID:	FBgn0033226	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001342115.1	Gene:	ABHD5 / 51099	HGNCID:	21396	Length:	349	Species:	Homo sapiens

Alignment Length:	353	Identity:	163/353 - (46%)
Similarity:	222/353 - (62%)	Gaps:	17/353 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KSSMDLEDPRNNRFFLWKWLCNWTSSSPTMLRAVEKKIL-----SYVKLPYRGFFVDIGPAVGEA 98
            :..:|..|......:|..||..|..:|.:.|:..|:|:|     :|.|.|.|         :...
Human     5 EEEVDSADTGERSGWLTGWLPTWCPTSISHLKEAEEKMLKCVPCTYKKEPVR---------ISNG 60

  Fly    99 DKIWTISMNTE-SKEVPLVLLHGLGAGIALWVMNLDAFAKGRPVYAMDILGFGRSSRPLFAKDAL 162
            :||||:..:.. |.:.|||||||.|.|:.||.:|.......|||||.|:|||||||||.|..||.
Human    61 NKIWTLKFSHNISNKTPLVLLHGFGGGLGLWALNFGDLCTNRPVYAFDLLGFGRSSRPRFDSDAE 125

  Fly   163 VCEKQFVKSVEEWRREMNINDMILLGHSMGGFIASSYALSHPERVKHLILADPWGFPEKPSDSTN 227
            ..|.|||:|:||||..:.::.||||||::|||:|::|:|.:|.||.||||.:||||||:|..:..
Human   126 EVENQFVESIEEWRCALGLDKMILLGHNLGGFLAAAYSLKYPSRVNHLILVEPWGFPERPDLADQ 190

  Fly   228 GKTIPLWVRAIARVLTPLNPLWALRAAGPFGQWVVQKTRPDIMRKFQSTIEEDINLLPQYIHQCN 292
            .:.||:|:||:...|||.|||..||.|||||..:||:.|||..||:.|..|:|  .:.:||:.||
Human   191 DRPIPVWIRALGAALTPFNPLAGLRIAGPFGLSLVQRLRPDFKRKYSSMFEDD--TVTEYIYHCN 253

  Fly   293 AQNPSGESAFHTMMQSFGWAKHPMIHRIKDVRSDIPITFIYGSRSWIDSSSGEKIKSQRGSNMVD 357
            .|.||||:||..|...:||||.||:.||..:..|||::.|:|:||.||.:||..|:|.|..:.|.
Human   254 VQTPSGETAFKNMTIPYGWAKRPMLQRIGKMHPDIPVSVIFGARSCIDGNSGTSIQSLRPHSYVK 318

  Fly   358 IKIVTGAGHHVYADKPDVFNRYVNETCD 385
            ...:.||||:||||:|:.||:.|.|.||
Human   319 TIAILGAGHYVYADQPEEFNQKVKEICD 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puml	NP_001286169.1	MhpC	114..382	CDD:223669	140/267 (52%)
puml	NP_001286169.1	Abhydrolase_5	114..>226	CDD:289465	65/111 (59%)
ABHD5	NP_001342115.1	Abhydrolase_1	1..345	CDD:331148	161/350 (46%)
ABHD5	NP_001342115.1	HXXXXD motif	327..332		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147352
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4409
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2347
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57834
OrthoDB	1	1.010	-	-		D1555935at2759
OrthoFinder	1	1.000	-	-		FOG0001034
OrthoInspector	1	1.000	-	-		otm42202
orthoMCL	1	0.900	-	-		OOG6_101137
Panther	1	1.100	-	-	O	PTHR42886
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R207
SonicParanoid	1	1.000	-	-		X562
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800